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Entry version 102 (02 Jun 2021)
Sequence version 1 (06 Feb 2007)
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Protein

Zinc finger protein 423

Gene

znf423

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri76 – 98C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri318 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri346 – 368C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 461C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri469 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri513 – 536C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri555 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri603 – 628C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri675 – 697C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 728C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri736 – 759C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri764 – 787C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri794 – 817C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri831 – 853C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri857 – 880C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri954 – 976C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1000 – 1022C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1090 – 1112C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1201 – 1224C2H2-type 25PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1249 – 1271C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1279 – 1301C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1310 – 1333C2H2-type 28PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1340 – 1363C2H2-type 29PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 423
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:znf423
ORF Names:si:ch211-216l23.1, zgc:158272
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-4368, znf423

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003085981 – 1365Zinc finger protein 423Add BLAST1365

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L1R6

PeptideAtlas

More...
PeptideAtlasi
A1L1R6

PRoteomics IDEntifications database

More...
PRIDEi
A1L1R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000059707, Expressed in retina and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1L1R6, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000077731

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L1R6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 69DisorderedSequence analysisAdd BLAST69
Regioni99 – 126DisorderedSequence analysisAdd BLAST28
Regioni250 – 280DisorderedSequence analysisAdd BLAST31
Regioni366 – 429DisorderedSequence analysisAdd BLAST64
Regioni885 – 916DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 65Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi254 – 278Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi372 – 417Polar residuesSequence analysisAdd BLAST46
Compositional biasi888 – 916Polar residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 98C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri318 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri346 – 368C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 461C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri469 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri513 – 536C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri555 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri603 – 628C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri675 – 697C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 728C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri736 – 759C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri764 – 787C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri794 – 817C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri831 – 853C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri857 – 880C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri954 – 976C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1000 – 1022C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1090 – 1112C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1201 – 1224C2H2-type 25PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1249 – 1271C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1279 – 1301C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1310 – 1333C2H2-type 28PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1340 – 1363C2H2-type 29PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004018_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L1R6

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L1R6

TreeFam database of animal gene trees

More...
TreeFami
TF331504

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 27 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A1L1R6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQAKPR SVKAVEEAES TECASGWDSS VQTDAAVSER DSDRKESRAV
60 70 80 90 100
GEDGEQSVTS HDERVGEEDL DDDSIFTCDN CQQDFECLAD LTEHRTNHCP
110 120 130 140 150
ADGDDDPGLS WVASSPSSKD VASPSQMLGD GCCDMGMGTG EEEGGSGLPY
160 170 180 190 200
PCQFCDKSFS RLSYLKRHEQ IHSDKLPFKC TFCSRLFKHK RSRDRHVKLH
210 220 230 240 250
TGDKKYSCQE CEAAFSRSDH LKIHLKTHSS SKPFKCSICK RGFSSTSSLQ
260 270 280 290 300
SHMQAHRKNK EHLAKKDQGK RDGSSSDVTE QDQDLYMCDY CEETFSQTDE
310 320 330 340 350
LEKHVLTQHP QLSDRAELQC IHCPEIFSDE GTLLTHIDRT HANKKHKCPM
360 370 380 390 400
CAEQFPSVED VYCHLDSHRQ PDSSNHSASP DPVLGSVASM SSATPDSSAS
410 420 430 440 450
LERGSTPDST LKPGQSRRKL APSSDHDDGT WSGKVTYSCP YCSKRDFNSL
460 470 480 490 500
AVLEIHLKTI HADKPQQSHT CQLCLETLPT LYNLNEHVRK AHRSSGNSAS
510 520 530 540 550
NFPLLQFSNV SAFHCNYCPD MFADINSLQE HIRVSHCLSG GVVAGSTTLE
560 570 580 590 600
GNHAFFCNQC SMGFLTESSL TEHIQQTHCS SVGGVTKMES PVLQPSQSFM
610 620 630 640 650
EVYSCPYCTN SPIFGSLLKL TKHIKENHKN IPLANNKRKV KVADLSPASS
660 670 680 690 700
DVEISSPKRH RVTGDSTPAV ANGDYPCNQC DLRFSSFEGF QAHLKSHLEL
710 720 730 740 750
LLRRQSCPQC NKEDFDSQEA LLQHLTIHYT TTSTQYVCES CDKQFSSVDD
760 770 780 790 800
LQKHLLDMHT FVLYHCTLCQ EVFDSKVSIQ VHLAVKHSNE KKMYRCTACA
810 820 830 840 850
WDFRKESDLQ LHVKHSHLGH PASTGAPGKA RKCIFCGETF GTEVELQCHI
860 870 880 890 900
TTHSKKYNCR LCGKAFHAIV LLERHLREKH CIFDGGNGNG NGGSQNGTPN
910 920 930 940 950
GVTQSSKRST AGSTAAAEQA DLQNMLLKGG SQETANSHEA SGGEEELDAS
960 970 980 990 1000
EPMYACDICG AAYTMESLLQ NHRLRDHNIR PGEDDAGSRK KKADFIKGNH
1010 1020 1030 1040 1050
KCNVCSRTFF SENGLREHAQ THRGPAKHYM CPICGERFPS LLTLTEHKVT
1060 1070 1080 1090 1100
HSKSLDTGTC RICKMPLQSE EEFIEHCQMH PDLRNSLTGF RCVVCMQTVT
1110 1120 1130 1140 1150
STLELKIHGT FHMQKLSSSG GSGGGGGSAS SSPNGQLQAH KLYKCALCLK
1160 1170 1180 1190 1200
DFKNKQELVK IDVNGLPYGL CAGCMSRGTN GQSPTVVVTP QEAGDKGTTG
1210 1220 1230 1240 1250
LRCSECAVKF ETLEDLESHI QVDHTEMSPE TSGAKKVTDA SPVPKKKTYQ
1260 1270 1280 1290 1300
CIKCQMTFET EREIQIHVAN HMIEEGINHE CKLCNQMFDS PAKLLCHLIE
1310 1320 1330 1340 1350
HSFEGMGGTF KCPVCFTVFV QANKLQQHIF AVHGQEDKIY DCSQCPQKFF
1360
FQTELQNHTL SQHAQ
Length:1,365
Mass (Da):151,465
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B53BE488AE40D49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8PYF9A0A2R8PYF9_DANRE
Si:ch211-216l23.1
znf423 si:ch211-216l23.1
1,352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TVM2A0A2U3TVM2_DANRE
Si:ch211-216l23.1
znf423 si:ch211-216l23.1
1,372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YIT3Z4YIT3_DANRE
Si:ch211-216l23.1
znf423 si:ch211-216l23.1
1,275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QLR2A0A2R8QLR2_DANRE
Si:ch211-216l23.1
znf423 si:ch211-216l23.1
1,379Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QQN4A0A2R8QQN4_DANRE
Si:ch211-216l23.1
znf423 si:ch211-216l23.1
1,378Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RI65A0A2R8RI65_DANRE
Si:ch211-216l23.1
znf423 si:ch211-216l23.1
1,372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QTL6A0A2R8QTL6_DANRE
Si:ch211-216l23.1
znf423 si:ch211-216l23.1
1,370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QB22F1QB22_DANRE
Zinc finger protein 423
znf423
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX470162 Genomic DNA Translation: CAK04518.1
CR387935 Genomic DNA Translation: CAK04486.1
BC129184 mRNA Translation: AAI29185.1

NCBI Reference Sequences

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RefSeqi
NP_001073499.1, NM_001080030.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000189493; ENSDARP00000146416; ENSDARG00000059707

Database of genes from NCBI RefSeq genomes

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GeneIDi
566696

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dre:566696

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470162 Genomic DNA Translation: CAK04518.1
CR387935 Genomic DNA Translation: CAK04486.1
BC129184 mRNA Translation: AAI29185.1
RefSeqiNP_001073499.1, NM_001080030.1

3D structure databases

SMRiA1L1R6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077731

Proteomic databases

PaxDbiA1L1R6
PeptideAtlasiA1L1R6
PRIDEiA1L1R6

Genome annotation databases

EnsembliENSDART00000189493; ENSDARP00000146416; ENSDARG00000059707
GeneIDi566696
KEGGidre:566696

Organism-specific databases

ZFINiZDB-GENE-030131-4368, znf423

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000158492
HOGENOMiCLU_004018_0_0_1
InParanoidiA1L1R6
OrthoDBi1318335at2759
PhylomeDBiA1L1R6
TreeFamiTF331504

Miscellaneous databases

Protein Ontology

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PROi
PR:A1L1R6

Gene expression databases

BgeeiENSDARG00000059707, Expressed in retina and 27 other tissues
ExpressionAtlasiA1L1R6, baseline

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 30 hits
SUPFAMiSSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 27 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN423_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L1R6
Secondary accession number(s): Q1L943, Q1LX66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: June 2, 2021
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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