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Protein
Submitted name:

Protein kinase, cAMP-dependent, catalytic, alpha

Gene

Prkaca

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-163615 PKA activation
R-RNO-164378 PKA activation in glucagon signalling
R-RNO-180024 DARPP-32 events
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-380259 Loss of Nlp from mitotic centrosomes
R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-392517 Rap1 signalling
R-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-4420097 VEGFA-VEGFR2 Pathway
R-RNO-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5578775 Ion homeostasis
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-5621575 CD209 (DC-SIGN) signaling
R-RNO-5687128 MAPK6/MAPK4 signaling
R-RNO-8853659 RET signaling
R-RNO-8854518 AURKA Activation by TPX2
R-RNO-8963896 HDL assembly
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase, cAMP-dependent, catalytic, alphaImported
Submitted name:
cAMP-dependent protein kinase catalytic subunit alphaImported
Gene namesi
Name:PrkacaImported
ORF Names:rCG_51506Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi3389 Prkaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000005257 Expressed in 10 organ(s), highest expression level in heart

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 298Protein kinaseInterPro annotationAdd BLAST255
Domaini299 – 351AGC-kinase C-terminalInterPro annotationAdd BLAST53

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0616 Eukaryota
ENOG410XPQQ LUCA
GeneTreeiENSGT00810000125385
HOVERGENiHBG108317
KOiK04345
OMAiHSHDIIY
OrthoDBiEOG091G10O8
TreeFamiTF313399

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR039035 PKA_C-alpha
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PTHR24353:SF82 PTHR24353:SF82, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1L1M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WETPSQNTAQ LDHFDRIKTL
60 70 80 90 100
GTGSFGRVML VKHKESGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN
110 120 130 140 150
FPFLVKLEFS FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ
160 170 180 190 200
IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY IQVTDFGFAK RVKGRTWTLC
210 220 230 240 250
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK
260 270 280 290 300
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT
310 320 330 340 350
TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFTE

F
Length:351
Mass (Da):40,606
Last modified:February 6, 2007 - v1
Checksum:i3065123824A47880
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P27791KAPCA_RAT
cAMP-dependent protein kinase catal...
Prkaca
351Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043167 Genomic DNA No translation available.
BC129128 mRNA Translation: AAI29129.1
CH473972 Genomic DNA Translation: EDL92251.1
RefSeqiNP_001094392.1, NM_001100922.1
UniGeneiRn.20

Genome annotation databases

EnsembliENSRNOT00000041717; ENSRNOP00000044732; ENSRNOG00000005257
GeneIDi25636
KEGGirno:25636

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07043167 Genomic DNA No translation available.
BC129128 mRNA Translation: AAI29129.1
CH473972 Genomic DNA Translation: EDL92251.1
RefSeqiNP_001094392.1, NM_001100922.1
UniGeneiRn.20

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000041717; ENSRNOP00000044732; ENSRNOG00000005257
GeneIDi25636
KEGGirno:25636

Organism-specific databases

CTDi5566
RGDi3389 Prkaca

Phylogenomic databases

eggNOGiKOG0616 Eukaryota
ENOG410XPQQ LUCA
GeneTreeiENSGT00810000125385
HOVERGENiHBG108317
KOiK04345
OMAiHSHDIIY
OrthoDBiEOG091G10O8
TreeFamiTF313399

Enzyme and pathway databases

ReactomeiR-RNO-163615 PKA activation
R-RNO-164378 PKA activation in glucagon signalling
R-RNO-180024 DARPP-32 events
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-380259 Loss of Nlp from mitotic centrosomes
R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-392517 Rap1 signalling
R-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-4420097 VEGFA-VEGFR2 Pathway
R-RNO-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5578775 Ion homeostasis
R-RNO-5610785 GLI3 is processed to GLI3R by the proteasome
R-RNO-5610787 Hedgehog 'off' state
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-5621575 CD209 (DC-SIGN) signaling
R-RNO-5687128 MAPK6/MAPK4 signaling
R-RNO-8853659 RET signaling
R-RNO-8854518 AURKA Activation by TPX2
R-RNO-8963896 HDL assembly
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Gene expression databases

BgeeiENSRNOG00000005257 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR039035 PKA_C-alpha
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PTHR24353:SF82 PTHR24353:SF82, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1L1M0_RAT
AccessioniPrimary (citable) accession number: A1L1M0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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