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UniProtKB - A1L1L7 (ZN426_RAT)
Protein
Zinc finger protein 426
Gene
Znf426
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in transcriptional regulation.
CuratedRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 361 – 383 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 417 – 439 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 445 – 467 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 473 – 495 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 501 – 525 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 531 – 553 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 426 |
Gene namesi | Name:Znf426 Synonyms:Zfp426 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308643, Zfp426 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284701 | 1 – 553 | Zinc finger protein 426Add BLAST | 553 |
Proteomic databases
PaxDbi | A1L1L7 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000033624, Expressed in brain and 22 other tissues |
ExpressionAtlasi | A1L1L7, baseline and differential |
Genevisiblei | A1L1L7, RN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 111 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 222 – 244 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 277 – 299 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 305 – 327 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 361 – 383 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 417 – 439 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 445 – 467 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 473 – 495 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 501 – 525 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 531 – 553 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163292 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | A1L1L7 |
OMAi | YECEECL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A1L1L7 |
TreeFami | TF342172 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A1L1L7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT
60 70 80 90 100
QEEWTSLNPD QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG
110 120 130 140 150
QKIVFPEWKI QLETQCSASQ QELLRGNISN GMQTQTGSDT GRGLCDGTQY
160 170 180 190 200
GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK DFLMLQRKKC AGEKLSEFNQ
210 220 230 240 250
SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH QRTHSGDKLY
260 270 280 290 300
ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT
310 320 330 340 350
GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI
360 370 380 390 400
HVRSHNGDKP YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI
410 420 430 440 450
SSNLNGHLKM HAEEKTCECK ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC
460 470 480 490 500
GKAFNYSTHL KIHMRIHTGE KPYECKQCGK AFSHSTSFQI HERTHTGEKP
510 520 530 540 550
YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY SHPRSLRRHE
RIH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JW15 | A0A0G2JW15_RAT | Zinc finger protein 266 | Zfp266 | 604 | Annotation score: | ||
F1MAL0 | F1MAL0_RAT | Zinc finger protein 266 | Zfp266 | 531 | Annotation score: | ||
A0A0H2UHW3 | A0A0H2UHW3_RAT | Zinc finger protein 426 | Zfp426 | 478 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC129125 mRNA Translation: AAI29126.1 |
RefSeqi | NP_001073412.1, NM_001079943.1 XP_006242728.1, XM_006242666.1 XP_006242729.1, XM_006242667.3 XP_006242730.1, XM_006242668.3 XP_006242732.1, XM_006242670.2 XP_008764203.1, XM_008765981.2 |
Genome annotation databases
Ensembli | ENSRNOT00000077465; ENSRNOP00000069966; ENSRNOG00000033624 |
GeneIDi | 690895 |
KEGGi | rno:690895 |
UCSCi | RGD:1308643, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC129125 mRNA Translation: AAI29126.1 |
RefSeqi | NP_001073412.1, NM_001079943.1 XP_006242728.1, XM_006242666.1 XP_006242729.1, XM_006242667.3 XP_006242730.1, XM_006242668.3 XP_006242732.1, XM_006242670.2 XP_008764203.1, XM_008765981.2 |
3D structure databases
SMRi | A1L1L7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000038875 |
Proteomic databases
PaxDbi | A1L1L7 |
Genome annotation databases
Ensembli | ENSRNOT00000077465; ENSRNOP00000069966; ENSRNOG00000033624 |
GeneIDi | 690895 |
KEGGi | rno:690895 |
UCSCi | RGD:1308643, rat |
Organism-specific databases
CTDi | 235028 |
RGDi | 1308643, Zfp426 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163292 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | A1L1L7 |
OMAi | YECEECL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A1L1L7 |
TreeFami | TF342172 |
Enzyme and pathway databases
Reactomei | R-RNO-212436, Generic Transcription Pathway |
Miscellaneous databases
PROi | PR:A1L1L7 |
Gene expression databases
Bgeei | ENSRNOG00000033624, Expressed in brain and 22 other tissues |
ExpressionAtlasi | A1L1L7, baseline and differential |
Genevisiblei | A1L1L7, RN |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN426_RAT | |
Accessioni | A1L1L7Primary (citable) accession number: A1L1L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | September 29, 2021 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |