UniProtKB - A1L1L7 (ZN426_RAT)

BLAST

>sp|A1L1L7|ZN426_RAT Zinc finger protein 426 OS=Rattus norvegicus OX=10116 GN=Znf426 PE=2 SV=1
MAAPDSLSHGPSGDSVCLQEEKVSAEMMLVDCLTNYQELVSFDDVIVDFTQEEWTSLNPD
QRTLYREVMLENYKNLATVGYQLIKPSVISWLEQEEFSTGQKIVFPEWKIQLETQCSASQ
QELLRGNISNGMQTQTGSDTGRGLCDGTQYGDFFSELSPLRTVMKTRPAQDNYDSSQCRK
DFLMLQRKKCAGEKLSEFNQSEETGAIPGKAYQKMATQEKCFECSDCGKSFMNQSHLQTH
QRTHSGDKLYELNECGRSFINSRLAVLIETLNAKKPHRCKECGKGYRYPAYLNIHMRTHT
GEKPYECKECGKAFNYSNSFQIHGRTHTGEKPYVCNQCGKAFTQHSGLSIHVRSHNGDKP
YACKECGKAFLTSSRLIQHIRTHTGEKPFVCVKCGKAFAISSNLNGHLKMHAEEKTCECK
ICGKAFGYLSCLNNHMRTHNAKKSYTCKECGKAFNYSTHLKIHMRIHTGEKPYECKQCGK
AFSHSTSFQIHERTHTGEKPYECKECGKAFICPSSFRIHEISHTHTEEKPYKCQQCGKAY
SHPRSLRRHERIH

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History
Entry version 83 (07 Nov 2018)
Sequence version 1 (06 Feb 2007)
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Protein

Zinc finger protein 426

Gene

Znf426

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May be involved in transcriptional regulation.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	222 – 244	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	277 – 299	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	305 – 327	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	333 – 355	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	361 – 383	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	389 – 411	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	417 – 439	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	445 – 467	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	473 – 495	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	501 – 525	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	531 – 553	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-212436 Generic Transcription Pathway

Reactomeⁱ

R-RNO-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 426
Gene namesⁱ	Name:Znf426 Synonyms:Zfp426
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 8

Organism-specific databases

Rat genome database More...RGDⁱ	1308643 Zfp426

RGDⁱ

1308643 Zfp426

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000284701	1 – 553	Zinc finger protein 426Add BLAST		553

Proteomic databases

PaxDbⁱ	A1L1L7
PRIDEⁱ	A1L1L7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000033624 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	A1L1L7 baseline and differential
Genevisibleⁱ	A1L1L7 RN

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000038875

STRINGⁱ

10116.ENSRNOP00000038875

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1L1L7
SMRⁱ	A1L1L7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	40 – 111	KRABPROSITE-ProRule annotationAdd BLAST		72

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	222 – 244	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	277 – 299	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	305 – 327	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	333 – 355	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	361 – 383	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	389 – 411	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	417 – 439	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	445 – 467	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	473 – 495	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	501 – 525	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	531 – 553	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144146
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	A1L1L7
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	THMRTQS
PhylomeDBⁱ	A1L1L7
TreeFamⁱ	TF342172

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 10 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 11 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 11 hits PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

A1L1L7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT 
        60         70         80         90        100
QEEWTSLNPD QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG 
       110        120        130        140        150
QKIVFPEWKI QLETQCSASQ QELLRGNISN GMQTQTGSDT GRGLCDGTQY 
       160        170        180        190        200
GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK DFLMLQRKKC AGEKLSEFNQ 
       210        220        230        240        250
SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH QRTHSGDKLY 
       260        270        280        290        300
ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT 
       310        320        330        340        350
GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI 
       360        370        380        390        400
HVRSHNGDKP YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI 
       410        420        430        440        450
SSNLNGHLKM HAEEKTCECK ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC 
       460        470        480        490        500
GKAFNYSTHL KIHMRIHTGE KPYECKQCGK AFSHSTSFQI HERTHTGEKP 
       510        520        530        540        550
YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY SHPRSLRRHE 

RIH

Length:553

Mass (Da):63,005

Last modified:February 6, 2007 - v1

Checksum:ⁱ358C5C0EFB5BA73C

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0G2JW15	A0A0G2JW15_RAT	Zinc finger protein 266 Zinc finger protein 266	Zfp266	604	Annotation score:
F1MAL0	F1MAL0_RAT	Zinc finger protein 266 Zinc finger protein 266	Zfp266	531	Annotation score:
A0A0H2UHW3	A0A0H2UHW3_RAT	Zinc finger protein 426 Zinc finger protein 426	Zfp426	478	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC129125 mRNA Translation: AAI29126.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073412.1, NM_001079943.1 XP_006242728.1, XM_006242666.1 XP_006242729.1, XM_006242667.3 XP_006242730.1, XM_006242668.3 XP_006242732.1, XM_006242670.2 XP_008764203.1, XM_008765981.2
UniGeneⁱ	Rn.120278

Genome annotation databases

Ensemblⁱ	ENSRNOT00000077465; ENSRNOP00000069966; ENSRNOG00000033624
GeneIDⁱ	690895
KEGGⁱ	rno:690895
UCSC genome browser More...UCSCⁱ	RGD:1308643 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A1L1L7	Zinc finger protein 426		MOUSE		550	UniRef90_Q8R1D1
Zinc finger protein 426		RAT		478
UPI000A31284F		MUSPA		559
UPI000A316B03		MUSCR		552
Zinc finger protein 426		MOUSE		564
+14

Protein	Similar proteins		Species	Score	Length	Source
A1L1L7	Zinc finger protein 426		MOUSE		550	UniRef50_Q8R1D1
Zinc finger protein 426		RAT		478
Zinc finger protein		CRIGR		523
zinc finger protein 426-like isoform X2		MESAU		525
Uncharacterized protein		COLAP		524
+37

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC129125 mRNA Translation: AAI29126.1
RefSeqⁱ	NP_001073412.1, NM_001079943.1 XP_006242728.1, XM_006242666.1 XP_006242729.1, XM_006242667.3 XP_006242730.1, XM_006242668.3 XP_006242732.1, XM_006242670.2 XP_008764203.1, XM_008765981.2
UniGeneⁱ	Rn.120278

3D structure databases

ProteinModelPortalⁱ	A1L1L7
SMRⁱ	A1L1L7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000038875

STRINGⁱ

10116.ENSRNOP00000038875

Proteomic databases

PaxDbⁱ	A1L1L7
PRIDEⁱ	A1L1L7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000077465; ENSRNOP00000069966; ENSRNOG00000033624
GeneIDⁱ	690895
KEGGⁱ	rno:690895
UCSCⁱ	RGD:1308643 rat

Organism-specific databases

CTDⁱ	235028
RGDⁱ	1308643 Zfp426

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00910000144146
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	A1L1L7
KOⁱ	K09228
OMAⁱ	THMRTQS
PhylomeDBⁱ	A1L1L7
TreeFamⁱ	TF342172

Enzyme and pathway databases

Reactomeⁱ	R-RNO-212436 Generic Transcription Pathway

Reactomeⁱ

R-RNO-212436 Generic Transcription Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A1L1L7

PROⁱ

PR:A1L1L7

Gene expression databases

Bgeeⁱ	ENSRNOG00000033624 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	A1L1L7 baseline and differential
Genevisibleⁱ	A1L1L7 RN

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 10 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 11 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 11 hits PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN426_RAT
Accessionⁱ	A1L1L7Primary (citable) accession number: A1L1L7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
	Last sequence update:	February 6, 2007
	Last modified:	November 7, 2018
	This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1L1L7 (ZN426_RAT)

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Zinc finger protein 426

Znf426

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ