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Protein

Zinc finger protein 426

Gene

Znf426

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 426
Gene namesi
Name:Znf426
Synonyms:Zfp426
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1308643 Zfp426

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002847011 – 553Zinc finger protein 426Add BLAST553

Proteomic databases

PaxDbiA1L1L7
PRIDEiA1L1L7

Expressioni

Gene expression databases

BgeeiENSRNOG00000033624
ExpressionAtlasiA1L1L7 baseline and differential
GenevisibleiA1L1L7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038875

Structurei

3D structure databases

ProteinModelPortaliA1L1L7
SMRiA1L1L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 111KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 525C2H2-type 10PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri531 – 553C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144146
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA1L1L7
KOiK09228
OMAiAFNYSTH
PhylomeDBiA1L1L7
TreeFamiTF342172

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

A1L1L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT
60 70 80 90 100
QEEWTSLNPD QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG
110 120 130 140 150
QKIVFPEWKI QLETQCSASQ QELLRGNISN GMQTQTGSDT GRGLCDGTQY
160 170 180 190 200
GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK DFLMLQRKKC AGEKLSEFNQ
210 220 230 240 250
SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH QRTHSGDKLY
260 270 280 290 300
ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT
310 320 330 340 350
GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI
360 370 380 390 400
HVRSHNGDKP YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI
410 420 430 440 450
SSNLNGHLKM HAEEKTCECK ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC
460 470 480 490 500
GKAFNYSTHL KIHMRIHTGE KPYECKQCGK AFSHSTSFQI HERTHTGEKP
510 520 530 540 550
YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY SHPRSLRRHE

RIH
Length:553
Mass (Da):63,005
Last modified:February 6, 2007 - v1
Checksum:i358C5C0EFB5BA73C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129125 mRNA Translation: AAI29126.1
RefSeqiNP_001073412.1, NM_001079943.1
XP_006242728.1, XM_006242666.1
XP_006242729.1, XM_006242667.3
XP_006242730.1, XM_006242668.3
XP_006242732.1, XM_006242670.2
XP_008764203.1, XM_008765981.2
UniGeneiRn.120278

Genome annotation databases

EnsembliENSRNOT00000077465; ENSRNOP00000069966; ENSRNOG00000033624
GeneIDi690895
KEGGirno:690895
UCSCiRGD:1308643 rat

Similar proteinsi

Entry informationi

Entry nameiZN426_RAT
AccessioniPrimary (citable) accession number: A1L1L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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