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UniProtKB - A1L1L5 (A1L1L5_RAT)
Protein
Submitted name:
Ccnk protein
Gene
Ccnk
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase activator activity Source: GO_Central
- cyclin-dependent protein serine/threonine kinase activity Source: RGD
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- protein kinase binding Source: RGD
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: RGD
GO - Biological processi
- cellular response to DNA damage stimulus Source: RGD
- in utero embryonic development Source: RGD
- negative regulation by host of viral genome replication Source: RGD
- negative regulation of stem cell differentiation Source: RGD
- phosphorylation of RNA polymerase II C-terminal domain Source: Ensembl
- positive regulation of DNA-templated transcription, elongation Source: GO_Central
- positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues Source: RGD
- positive regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
- regulation of signal transduction Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | CyclinUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-112382, Formation of RNA Pol II elongation complex R-RNO-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-RNO-674695, RNA Polymerase II Pre-transcription Events R-RNO-6796648, TP53 Regulates Transcription of DNA Repair Genes R-RNO-6807505, RNA polymerase II transcribes snRNA genes R-RNO-75955, RNA Polymerase II Transcription Elongation |
Names & Taxonomyi
Protein namesi | Submitted name: Ccnk proteinImportedSubmitted name: Cyclin KImported |
Gene namesi | Name:CcnkImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1595690, Ccnk |
Subcellular locationi
Nucleus
- cyclin/CDK positive transcription elongation factor complex Source: GO_Central
- nucleus Source: GO_Central
Other locations
- cyclin K-CDK12 complex Source: RGD
- cyclin K-CDK13 complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000006985, Expressed in testis and 21 other tissues |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000053998 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 149 | CYCLINInterPro annotationAdd BLAST | 95 | |
Domaini | 158 – 278 | Cyclin_CInterPro annotationAdd BLAST | 121 | |
Domaini | 162 – 256 | CYCLINInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 262 – 589 | DisorderedSequence analysisAdd BLAST | 328 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 276 – 290 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 291 – 329 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 354 – 386 | Pro residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 409 – 437 | Pro residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 438 – 462 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 482 – 579 | Pro residuesSequence analysisAdd BLAST | 98 |
Sequence similaritiesi
Belongs to the cyclin family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0834, Eukaryota |
GeneTreei | ENSGT00940000156384 |
OMAi | AQPQQKD |
OrthoDBi | 1437076at2759 |
TreeFami | TF101010 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
i Sequence
Sequence statusi: Complete.
A1L1L5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR
60 70 80 90 100
REGARFIFDV GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL
110 120 130 140 150
FLAGKVEETP KKCKDIIKTA RSLLNDVQFG QFGDDPKEEV MVLERILLQT
160 170 180 190 200
IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK LVQMAWTFVN DSLCTTLSLQ
210 220 230 240 250
WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ DVPVDVLEDI
260 270 280 290 300
CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPPVPQ AQPSQGSEAA
310 320 330 340 350
QPQQKDAQQQ QQQQQQQQQQ QQQQAQQPKK PSPQPSPPRQ AKRAVVVSPK
360 370 380 390 400
EENKATEPPP PPKIPKLEAA HPPLPPAHPP PDRKLPLAPA LGEAEPTGPV
410 420 430 440 450
ETSDLPKVQI PPPAHPAPVH QPPPLPHRPP PPPPSSYMTG MSTTSSYMSG
460 470 480 490 500
EGYQSLQSMM KTEGPSYGAL PPAYGPPAHL TYHPHVYPPN PPPPPVPPPP
510 520 530 540 550
ASFPPPTIPP PTPGYPPPPP TYNPNFPPPP PRLPPTHAVP PHPPPGLGLP
560 570 580
PASYPPPAVP PGGQPPVPPP IPPPGMPPVG GLGRAAWMR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07065498 Genomic DNA No translation available. BC129121 mRNA Translation: AAI29122.1 |
RefSeqi | NP_001103142.1, NM_001109672.1 XP_006240611.1, XM_006240549.3 XP_006240613.1, XM_006240551.3 |
Genome annotation databases
Ensembli | ENSRNOT00000057171; ENSRNOP00000053998; ENSRNOG00000006985 ENSRNOT00000083208; ENSRNOP00000074580; ENSRNOG00000006985 |
GeneIDi | 500715 |
KEGGi | rno:500715 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07065498 Genomic DNA No translation available. BC129121 mRNA Translation: AAI29122.1 |
RefSeqi | NP_001103142.1, NM_001109672.1 XP_006240611.1, XM_006240549.3 XP_006240613.1, XM_006240551.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000053998 |
Genome annotation databases
Ensembli | ENSRNOT00000057171; ENSRNOP00000053998; ENSRNOG00000006985 ENSRNOT00000083208; ENSRNOP00000074580; ENSRNOG00000006985 |
GeneIDi | 500715 |
KEGGi | rno:500715 |
Organism-specific databases
CTDi | 8812 |
RGDi | 1595690, Ccnk |
Phylogenomic databases
eggNOGi | KOG0834, Eukaryota |
GeneTreei | ENSGT00940000156384 |
OMAi | AQPQQKD |
OrthoDBi | 1437076at2759 |
TreeFami | TF101010 |
Enzyme and pathway databases
Reactomei | R-RNO-112382, Formation of RNA Pol II elongation complex R-RNO-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-RNO-674695, RNA Polymerase II Pre-transcription Events R-RNO-6796648, TP53 Regulates Transcription of DNA Repair Genes R-RNO-6807505, RNA polymerase II transcribes snRNA genes R-RNO-75955, RNA Polymerase II Transcription Elongation |
Gene expression databases
Bgeei | ENSRNOG00000006985, Expressed in testis and 21 other tissues |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A1L1L5_RAT | |
Accessioni | A1L1L5Primary (citable) accession number: A1L1L5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | January 19, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |