Ccnk

Functionⁱ

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
cyclin-dependent protein serine/threonine kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding Source: Ensembl
RNA polymerase II CTD heptapeptide repeat kinase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus Source: Ensembl
negative regulation by host of viral genome replication Source: Ensembl
negative regulation of cell cycle arrest Source: Ensembl
positive regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	CyclinUniRule annotationSAAS annotation

Molecular function

CyclinUniRule annotationSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-112382 Formation of RNA Pol II elongation complex R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-RNO-674695 RNA Polymerase II Pre-transcription Events R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes R-RNO-6807505 RNA polymerase II transcribes snRNA genes R-RNO-75955 RNA Polymerase II Transcription Elongation

Reactomeⁱ

R-RNO-112382 Formation of RNA Pol II elongation complex
R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-RNO-6807505 RNA polymerase II transcribes snRNA genes
R-RNO-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Ccnk proteinImported Submitted name: Cyclin KImported
Gene namesⁱ	Name:CcnkImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 6

Organism-specific databases

Rat genome database More...RGDⁱ	1595690 Ccnk

RGDⁱ

1595690 Ccnk

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000006985 Expressed in 10 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000006985 Expressed in 10 organ(s), highest expression level in testis

Interactionⁱ

GO - Molecular functionⁱ

protein kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053998

STRINGⁱ

10116.ENSRNOP00000053998

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	55 – 149	CYCLINInterPro annotationAdd BLAST	95
Domainⁱ	158 – 278	Cyclin_CInterPro annotationAdd BLAST	121
Domainⁱ	162 – 256	CYCLINInterPro annotationAdd BLAST	95

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	304 – 327	Sequence analysisAdd BLAST		24

Sequence similaritiesⁱ

Belongs to the cyclin family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0834 Eukaryota COG5333 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000220828
HOVERGENⁱ	HBG050836
OMAⁱ	NSYMSGE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H4W
TreeFamⁱ	TF101010

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR006671 Cyclin_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A1L1L5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR 
        60         70         80         90        100
REGARFIFDV GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL 
       110        120        130        140        150
FLAGKVEETP KKCKDIIKTA RSLLNDVQFG QFGDDPKEEV MVLERILLQT 
       160        170        180        190        200
IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK LVQMAWTFVN DSLCTTLSLQ 
       210        220        230        240        250
WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ DVPVDVLEDI 
       260        270        280        290        300
CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPPVPQ AQPSQGSEAA 
       310        320        330        340        350
QPQQKDAQQQ QQQQQQQQQQ QQQQAQQPKK PSPQPSPPRQ AKRAVVVSPK 
       360        370        380        390        400
EENKATEPPP PPKIPKLEAA HPPLPPAHPP PDRKLPLAPA LGEAEPTGPV 
       410        420        430        440        450
ETSDLPKVQI PPPAHPAPVH QPPPLPHRPP PPPPSSYMTG MSTTSSYMSG 
       460        470        480        490        500
EGYQSLQSMM KTEGPSYGAL PPAYGPPAHL TYHPHVYPPN PPPPPVPPPP 
       510        520        530        540        550
ASFPPPTIPP PTPGYPPPPP TYNPNFPPPP PRLPPTHAVP PHPPPGLGLP 
       560        570        580 
PASYPPPAVP PGGQPPVPPP IPPPGMPPVG GLGRAAWMR

Length:589

Mass (Da):65,367

Last modified:February 6, 2007 - v1

Checksum:ⁱBA58E0A497A55F7F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07065498 Genomic DNA No translation available. BC129121 mRNA Translation: AAI29122.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001103142.1, NM_001109672.1 XP_006240611.1, XM_006240549.3 XP_006240613.1, XM_006240551.3
UniGeneⁱ	Rn.23

Genome annotation databases

Ensemblⁱ	ENSRNOT00000057171; ENSRNOP00000053998; ENSRNOG00000006985 ENSRNOT00000083208; ENSRNOP00000074580; ENSRNOG00000006985
GeneIDⁱ	500715
KEGGⁱ	rno:500715

Protein	Similar proteins		Species	Score	Length	Source
A1L1L5	Isoform 4 of Cyclin-K		HUMAN		600	UniRef90_O75909-4
CCNK isoform 5 (Fragment)		PONAB		227
CCNK isoform 5 (Fragment)		PANTR		227
Cyclin K (Predicted) (Fragment)		CALJA		248
Cyclin K (Predicted) (Fragment)		RHIFE		248
+48

Protein	Similar proteins		Species	Score	Length	Source
A1L1L5	Cyclin-K	)	HUMAN		580	UniRef50_O75909
Cyclin-K		MOUSE		554
CCNK isoform 2		PONAB		580
Uncharacterized protein		CERAT		580
Uncharacterized protein		PAPAN		580
+205

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07065498 Genomic DNA No translation available. BC129121 mRNA Translation: AAI29122.1
RefSeqⁱ	NP_001103142.1, NM_001109672.1 XP_006240611.1, XM_006240549.3 XP_006240613.1, XM_006240551.3
UniGeneⁱ	Rn.23

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000053998

STRINGⁱ

10116.ENSRNOP00000053998

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000057171; ENSRNOP00000053998; ENSRNOG00000006985 ENSRNOT00000083208; ENSRNOP00000074580; ENSRNOG00000006985
GeneIDⁱ	500715
KEGGⁱ	rno:500715

Organism-specific databases

CTDⁱ	8812
RGDⁱ	1595690 Ccnk

Phylogenomic databases

eggNOGⁱ	KOG0834 Eukaryota COG5333 LUCA
GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000220828
HOVERGENⁱ	HBG050836
OMAⁱ	NSYMSGE
OrthoDBⁱ	EOG091G0H4W
TreeFamⁱ	TF101010

Enzyme and pathway databases

Reactomeⁱ	R-RNO-112382 Formation of RNA Pol II elongation complex R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-RNO-674695 RNA Polymerase II Pre-transcription Events R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes R-RNO-6807505 RNA polymerase II transcribes snRNA genes R-RNO-75955 RNA Polymerase II Transcription Elongation

Reactomeⁱ

R-RNO-112382 Formation of RNA Pol II elongation complex
R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-RNO-674695 RNA Polymerase II Pre-transcription Events
R-RNO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-RNO-6807505 RNA polymerase II transcribes snRNA genes
R-RNO-75955 RNA Polymerase II Transcription Elongation

Gene expression databases

Bgeeⁱ	ENSRNOG00000006985 Expressed in 10 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000006985 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR006671 Cyclin_N
Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A1L1L5_RAT
Accessionⁱ	A1L1L5Primary (citable) accession number: A1L1L5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 6, 2007
	Last sequence update:	February 6, 2007
	Last modified:	October 10, 2018
	This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1L1L5 (A1L1L5_RAT)

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Ccnk protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ