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Protein

Transmembrane protein 214

Gene

Tmem214

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 214
Gene namesi
Name:Tmem214
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1311324 Tmem214

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003218992 – 685Transmembrane protein 214Add BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiA1L1L2
PeptideAtlasiA1L1L2
PRIDEiA1L1L2

Expressioni

Gene expression databases

BgeeiENSRNOG00000008812 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiA1L1L2 RN

Interactioni

Subunit structurei

Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011838

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 31Poly-Gly7

Sequence similaritiesi

Belongs to the TMEM214 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4467 Eukaryota
ENOG410ZR2A LUCA
GeneTreeiENSGT00390000002693
HOGENOMiHOG000074094
HOVERGENiHBG054145
InParanoidiA1L1L2
OMAiVKHANIF
OrthoDBiEOG091G0WVG
PhylomeDBiA1L1L2
TreeFamiTF329489

Family and domain databases

InterProiView protein in InterPro
IPR019308 TMEM214
PANTHERiPTHR13448 PTHR13448, 1 hit
PfamiView protein in Pfam
PF10151 TMEM214, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1L1L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARAAGSGG WEVVKRSRRP GASSGGRGGG GDRRALGEAN GVWKYDLSSP
60 70 80 90 100
IQPTSTLYER GFEKIMKRQN KEQVPPPAAE SKKPVNKKQP KKVTAVASQN
110 120 130 140 150
QKQGPFRSLE DALKALDVAA LQKELDKSQS VFTGNPSVWL KDLASYLNYK
160 170 180 190 200
LQTPRMEPTL SQYPHDYPYS LVSRELRGII RGLLTKAAGS VELFFDHCLF
210 220 230 240 250
TMLQELDKTP GESLHGYRIC IQAILQDKPK IVTSNLDKFL ELLRSHQSRP
260 270 280 290 300
AKCLTIMWAL GQAGFTNLTE GLKVWLGIML PVLGIKSLSP FAIAYLDRLL
310 320 330 340 350
LMYPNLTKGF GMIGPKDFFP LLDFAYMPNN SLSPSLQEQL CQLFPRLKVL
360 370 380 390 400
AFGAKPESSL HTYFPSFLSR ATPSCPAAMK KELLASLTQC LTVDPLSTSV
410 420 430 440 450
WRQLYPKHLS QSSLLLEHLL TSWEQIPKKA RKCLQETIQS FTLTNQELLK
460 470 480 490 500
KGSGSNEHVV TCDTACKGLL QQARGPRPPW ARLLLLLLVF AVGFLCHDLR
510 520 530 540 550
SHSSFQASLT GRLLQSSGLL PVAQQVCAKL YSYSLQSYNW LQETLPACGS
560 570 580 590 600
YLLAVVQPSL QLAWTYIYAT FSFLSAYCAS YLAFFSDSLA GVLQRVQLPE
610 620 630 640 650
ALHQLFHSLK ELLLLFYHSV LLPMWHLLLA ALAQVQEHCH EACRGEMTWD
660 670 680
CIKTQFSTAA HWTWLCLQDV TVAFLDWALT MISQQ
Length:685
Mass (Da):76,566
Last modified:February 6, 2007 - v1
Checksum:i76EAA04ECB7D1416
GO

Sequence cautioni

The sequence AAH85114 differs from that shown. Reason: Frameshift at position 194.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085114 mRNA Translation: AAH85114.1 Frameshift.
BC129115 mRNA Translation: AAI29116.1
RefSeqiNP_001014217.2, NM_001014195.2
UniGeneiRn.104487

Genome annotation databases

EnsembliENSRNOT00000011838; ENSRNOP00000011838; ENSRNOG00000008812
GeneIDi362711
KEGGirno:362711

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085114 mRNA Translation: AAH85114.1 Frameshift.
BC129115 mRNA Translation: AAI29116.1
RefSeqiNP_001014217.2, NM_001014195.2
UniGeneiRn.104487

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011838

Proteomic databases

PaxDbiA1L1L2
PeptideAtlasiA1L1L2
PRIDEiA1L1L2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011838; ENSRNOP00000011838; ENSRNOG00000008812
GeneIDi362711
KEGGirno:362711

Organism-specific databases

CTDi54867
RGDi1311324 Tmem214

Phylogenomic databases

eggNOGiKOG4467 Eukaryota
ENOG410ZR2A LUCA
GeneTreeiENSGT00390000002693
HOGENOMiHOG000074094
HOVERGENiHBG054145
InParanoidiA1L1L2
OMAiVKHANIF
OrthoDBiEOG091G0WVG
PhylomeDBiA1L1L2
TreeFamiTF329489

Miscellaneous databases

PROiPR:A1L1L2

Gene expression databases

BgeeiENSRNOG00000008812 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiA1L1L2 RN

Family and domain databases

InterProiView protein in InterPro
IPR019308 TMEM214
PANTHERiPTHR13448 PTHR13448, 1 hit
PfamiView protein in Pfam
PF10151 TMEM214, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM214_RAT
AccessioniPrimary (citable) accession number: A1L1L2
Secondary accession number(s): Q5U4F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: September 12, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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