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UniProtKB - A1L1J6 (ZN652_RAT)
Protein
Zinc finger protein 652
Gene
Znf652
Organism
Rattus norvegicus (Rat)
Status
Functioni
Functions as a transcriptional repressor.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 267 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 271 – 293 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 328 – 350 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 491 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 652 |
Gene namesi | Name:Znf652 Synonyms:Zfp652 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1566329, Zfp652 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280430 | 1 – 608 | Zinc finger protein 652Add BLAST | 608 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 100 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 196 | PhosphoserineBy similarity | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | A1L1J6 |
PRIDEi | A1L1J6 |
PTM databases
iPTMneti | A1L1J6 |
PhosphoSitePlusi | A1L1J6 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000017001, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | A1L1J6, RN |
Interactioni
Subunit structurei
Interacts with CBFA2T3.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000052376 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 234 | DisorderedSequence analysisAdd BLAST | 175 | |
Regioni | 497 – 608 | Mediates interaction with CBFA2T3By similarityAdd BLAST | 112 | |
Regioni | 540 – 589 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 67 – 98 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 117 – 145 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 149 – 165 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 169 – 189 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 194 – 209 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 548 – 562 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 563 – 578 | Pro residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 267 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 271 – 293 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 328 – 350 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 491 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157416 |
HOGENOMi | CLU_002678_74_2_1 |
InParanoidi | A1L1J6 |
OMAi | TEEQPFF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A1L1J6 |
TreeFami | TF332655 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
A1L1J6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYTASPCQE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLADSKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS
110 120 130 140 150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS
160 170 180 190 200
EEEEEETEED ATDNSSDYGE NGRQKKKEKQ VEKVRVTQRR TRRAASVAAA
210 220 230 240 250
TTSPTPRTTR GRRKSAELPK RKKRAAKEPK APVQKAKCDE KETLTCEKCP
260 270 280 290 300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC
310 320 330 340 350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH
360 370 380 390 400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR
410 420 430 440 450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT
460 470 480 490 500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP
510 520 530 540 550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MNPVGSALPS RPVPHPFSHL
560 570 580 590 600
HIHTHPHHSH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN
SPAQAQHH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC129097 mRNA Translation: AAI29098.1 |
RefSeqi | NP_001073676.1, NM_001080207.1 |
Genome annotation databases
Ensembli | ENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001 |
GeneIDi | 497984 |
KEGGi | rno:497984 |
UCSCi | RGD:1566329, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC129097 mRNA Translation: AAI29098.1 |
RefSeqi | NP_001073676.1, NM_001080207.1 |
3D structure databases
SMRi | A1L1J6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000052376 |
PTM databases
iPTMneti | A1L1J6 |
PhosphoSitePlusi | A1L1J6 |
Proteomic databases
PaxDbi | A1L1J6 |
PRIDEi | A1L1J6 |
Genome annotation databases
Ensembli | ENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001 |
GeneIDi | 497984 |
KEGGi | rno:497984 |
UCSCi | RGD:1566329, rat |
Organism-specific databases
CTDi | 268469 |
RGDi | 1566329, Zfp652 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157416 |
HOGENOMi | CLU_002678_74_2_1 |
InParanoidi | A1L1J6 |
OMAi | TEEQPFF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | A1L1J6 |
TreeFami | TF332655 |
Miscellaneous databases
PROi | PR:A1L1J6 |
Gene expression databases
Bgeei | ENSRNOG00000017001, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | A1L1J6, RN |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN652_RAT | |
Accessioni | A1L1J6Primary (citable) accession number: A1L1J6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | September 29, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families