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Protein

Zinc finger protein 652

Gene

Znf652

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri271 – 293C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 491C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 652
Gene namesi
Name:Znf652
Synonyms:Zfp652
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1566329 Zfp652

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804301 – 608Zinc finger protein 652Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1L1J6
PRIDEiA1L1J6

PTM databases

iPTMnetiA1L1J6
PhosphoSitePlusiA1L1J6

Expressioni

Gene expression databases

BgeeiENSRNOG00000017001 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiA1L1J6 RN

Interactioni

Subunit structurei

Interacts with CBFA2T3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052376

Structurei

3D structure databases

ProteinModelPortaliA1L1J6
SMRiA1L1J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni497 – 608Mediates interaction with CBFA2T3By similarityAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 108Poly-Glu5
Compositional biasi151 – 159Poly-Glu9
Compositional biasi496 – 574Pro-richAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri271 – 293C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 491C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00440000037877
HOGENOMiHOG000231037
HOVERGENiHBG064823
InParanoidiA1L1J6
OMAiGQSEDSF
OrthoDBiEOG091G055W
PhylomeDBiA1L1J6
TreeFamiTF332655

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

A1L1J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYTASPCQE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLADSKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS
110 120 130 140 150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS
160 170 180 190 200
EEEEEETEED ATDNSSDYGE NGRQKKKEKQ VEKVRVTQRR TRRAASVAAA
210 220 230 240 250
TTSPTPRTTR GRRKSAELPK RKKRAAKEPK APVQKAKCDE KETLTCEKCP
260 270 280 290 300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC
310 320 330 340 350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH
360 370 380 390 400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR
410 420 430 440 450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT
460 470 480 490 500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP
510 520 530 540 550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MNPVGSALPS RPVPHPFSHL
560 570 580 590 600
HIHTHPHHSH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN

SPAQAQHH
Length:608
Mass (Da):69,558
Last modified:February 6, 2007 - v1
Checksum:i65EEE1086C2C2EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129097 mRNA Translation: AAI29098.1
RefSeqiNP_001073676.1, NM_001080207.1
UniGeneiRn.137198

Genome annotation databases

EnsembliENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001
GeneIDi497984
KEGGirno:497984
UCSCiRGD:1566329 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129097 mRNA Translation: AAI29098.1
RefSeqiNP_001073676.1, NM_001080207.1
UniGeneiRn.137198

3D structure databases

ProteinModelPortaliA1L1J6
SMRiA1L1J6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052376

PTM databases

iPTMnetiA1L1J6
PhosphoSitePlusiA1L1J6

Proteomic databases

PaxDbiA1L1J6
PRIDEiA1L1J6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001
GeneIDi497984
KEGGirno:497984
UCSCiRGD:1566329 rat

Organism-specific databases

CTDi268469
RGDi1566329 Zfp652

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00440000037877
HOGENOMiHOG000231037
HOVERGENiHBG064823
InParanoidiA1L1J6
OMAiGQSEDSF
OrthoDBiEOG091G055W
PhylomeDBiA1L1J6
TreeFamiTF332655

Miscellaneous databases

PROiPR:A1L1J6

Gene expression databases

BgeeiENSRNOG00000017001 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiA1L1J6 RN

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN652_RAT
AccessioniPrimary (citable) accession number: A1L1J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 6, 2007
Last modified: November 7, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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