Znf652

Functionⁱ

Functions as a transcriptional repressor.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	244 – 267	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	271 – 293	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	328 – 350	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	356 – 378	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 462	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	468 – 491	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 652
Gene namesⁱ	Name:Znf652 Synonyms:Zfp652
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1566329 Zfp652

RGDⁱ

1566329 Zfp652

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280430	1 – 608	Zinc finger protein 652Add BLAST		608

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	57	PhosphoserineCombined sources	1
Modified residueⁱ	100	PhosphoserineCombined sources	1
Modified residueⁱ	103	PhosphothreonineCombined sources	1
Modified residueⁱ	196	PhosphoserineBy similarity	1
Modified residueⁱ	203	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	A1L1J6
PRIDEⁱ	A1L1J6

PTM databases

iPTMnetⁱ	A1L1J6
PhosphoSitePlusⁱ	A1L1J6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000017001 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	A1L1J6 RN

Interactionⁱ

Subunit structureⁱ

Interacts with CBFA2T3.By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000052376

STRINGⁱ

10116.ENSRNOP00000052376

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1L1J6
SMRⁱ	A1L1J6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	497 – 608	Mediates interaction with CBFA2T3By similarityAdd BLAST		112

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	104 – 108	Poly-Glu	5
Compositional biasⁱ	151 – 159	Poly-Glu	9
Compositional biasⁱ	496 – 574	Pro-richAdd BLAST	79

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	244 – 267	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	271 – 293	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	328 – 350	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	356 – 378	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 462	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	468 – 491	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000037877
HOGENOMⁱ	HOG000231037
HOVERGENⁱ	HBG064823
InParanoidⁱ	A1L1J6
OMAⁱ	GQSEDSF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G055W
PhylomeDBⁱ	A1L1J6
TreeFamⁱ	TF332655

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A1L1J6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSYTASPCQE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV 
        60         70         80         90        100
YKRESGSPYS VLADSKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS 
       110        120        130        140        150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS 
       160        170        180        190        200
EEEEEETEED ATDNSSDYGE NGRQKKKEKQ VEKVRVTQRR TRRAASVAAA 
       210        220        230        240        250
TTSPTPRTTR GRRKSAELPK RKKRAAKEPK APVQKAKCDE KETLTCEKCP 
       260        270        280        290        300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC 
       310        320        330        340        350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH 
       360        370        380        390        400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR 
       410        420        430        440        450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT 
       460        470        480        490        500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP 
       510        520        530        540        550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MNPVGSALPS RPVPHPFSHL 
       560        570        580        590        600
HIHTHPHHSH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN 

SPAQAQHH

Length:608

Mass (Da):69,558

Last modified:February 6, 2007 - v1

Checksum:ⁱ65EEE1086C2C2EF9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC129097 mRNA Translation: AAI29098.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073676.1, NM_001080207.1
UniGeneⁱ	Rn.137198

Genome annotation databases

Ensemblⁱ	ENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001
GeneIDⁱ	497984
KEGGⁱ	rno:497984
UCSC genome browser More...UCSCⁱ	RGD:1566329 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A1L1J6	Zinc finger protein 652		HUMAN		606	UniRef90_Q9Y2D9
LOW QUALITY PROTEIN: zinc finger protein 652		URSMA		665
Zinc finger protein 652 (Fragment)		wild yak		619
zinc finger protein 652		DIPOR		614
Uncharacterized protein		MUSPF		612
+142

Protein	Similar proteins		Species	Score	Length	Source
A1L1J6	Zinc finger protein 652		HUMAN		606	UniRef50_Q9Y2D9
LOW QUALITY PROTEIN: zinc finger protein 652		URSMA		665
Zinc finger protein 652 (Fragment)		wild yak		619
zinc finger protein 652		DIPOR		614
Uncharacterized protein		MUSPF		612
+142

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC129097 mRNA Translation: AAI29098.1
RefSeqⁱ	NP_001073676.1, NM_001080207.1
UniGeneⁱ	Rn.137198

3D structure databases

ProteinModelPortalⁱ	A1L1J6
SMRⁱ	A1L1J6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000052376

STRINGⁱ

10116.ENSRNOP00000052376

PTM databases

iPTMnetⁱ	A1L1J6
PhosphoSitePlusⁱ	A1L1J6

Proteomic databases

PaxDbⁱ	A1L1J6
PRIDEⁱ	A1L1J6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001
GeneIDⁱ	497984
KEGGⁱ	rno:497984
UCSCⁱ	RGD:1566329 rat

Organism-specific databases

CTDⁱ	268469
RGDⁱ	1566329 Zfp652

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00440000037877
HOGENOMⁱ	HOG000231037
HOVERGENⁱ	HBG064823
InParanoidⁱ	A1L1J6
OMAⁱ	GQSEDSF
OrthoDBⁱ	EOG091G055W
PhylomeDBⁱ	A1L1J6
TreeFamⁱ	TF332655

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A1L1J6

PROⁱ

PR:A1L1J6

Gene expression databases

Bgeeⁱ	ENSRNOG00000017001 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	A1L1J6 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN652_RAT
Accessionⁱ	A1L1J6Primary (citable) accession number: A1L1J6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	February 6, 2007
	Last modified:	November 7, 2018
	This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1L1J6 (ZN652_RAT)

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Zinc finger protein 652

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ