Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 51 (02 Jun 2021)
Sequence version 1 (06 Feb 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Tudor domain-containing protein 5

Gene

tdrd5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tdrd5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5884063, tdrd5.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004083491 – 963Tudor domain-containing protein 5Add BLAST963

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1L1H3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L1H3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 79HTH OST-type 1PROSITE-ProRule annotationAdd BLAST74
Domaini122 – 197HTH OST-type 2PROSITE-ProRule annotationAdd BLAST76
Domaini375 – 449HTH OST-type 3PROSITE-ProRule annotationAdd BLAST75
Domaini586 – 645TudorPROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni232 – 306DisorderedSequence analysisAdd BLAST75
Regioni739 – 763DisorderedSequence analysisAdd BLAST25
Regioni803 – 822DisorderedSequence analysisAdd BLAST20
Regioni864 – 891DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 306Polar residuesSequence analysisAdd BLAST55
Compositional biasi803 – 819Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDRD5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1115068at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09975, LOTUS_2_TDRD5, 1 hit
cd04508, TUDOR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1880, 3 hits
2.40.50.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041966, LOTUS-like
IPR025605, OST-HTH/LOTUS_dom
IPR035437, SNase_OB-fold_sf
IPR037982, TDRD5_LOTUS_2
IPR002999, Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12872, OST-HTH, 3 hits
PF00567, TUDOR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51644, HTH_OST, 3 hits
PS50304, TUDOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1L1H3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQERIMQRV QKDVRSLLIA SKNGLSIQEL EQDYRMMIGS QIPLRSLGYK
60 70 80 90 100
STMELLLDMP NVVQIHTQMD GTVNLSAVVD EATRKIADLV SCQKDRSTAR
110 120 130 140 150
SRNRRRNIRP RCPVDLVRRG RVSPVLPATV KSDLRDLLSL SPLLLSELEK
160 170 180 190 200
AFFSRFGRSF QYTRYGFYSM LEVLRSISDI VEVKQTRTGS LLVLRKSETG
210 220 230 240 250
HISASLCVKK SLDCQPAAVP NKTSCVFEKC LNEPQRPEKK PSEPATSLKI
260 270 280 290 300
SPPEFQKFSS QEPQSITSSR SFLHSSSNKE PDVNRNVSLG ESKKSIENKT
310 320 330 340 350
SPAVPSNNVV LNNSLVKNSE TFESLFTRMS KPVSHVEADH ANASEPNSSD
360 370 380 390 400
LNWLEKKLEK ELKLCLARKG AGGSVSDDLR SDIKHVVNQH SNGLNISLLP
410 420 430 440 450
TAFKSFTGKD LPFKELGFMS VMELVGSLGD ILCLESTDEG KDWKLFGAKK
460 470 480 490 500
EDLVDEFSAG LRSTNSSLSS WNSTRQSTAP LKPVGTIFSK VDEKLWWGPL
510 520 530 540 550
ELKVCSTEQI DIPPDAVRNQ KLHCLPRIKH SLMIGVYVES IESPSQFYVR
560 570 580 590 600
CCGKDTSEKL EDMMIEMRHC YSNECVSERY IVPDNCISVG QIYALRVPGD
610 620 630 640 650
VWWYRVIVHS IKNSELLDVF YPDFGNVATV KKSWLRFLKN CYMKVPAQAV
660 670 680 690 700
PSSLPFVTST EAQWSTQAIK RFRQLCSCLP LVGLVLQYVQ DVLVIFLCDT
710 720 730 740 750
SSAEDVYLHQ LLIAQGLAKM EPEHACKKVS RNTFMHYLTP SQEKPQEESS
760 770 780 790 800
KSSVPSESSQ SEVLCTKETI LQVIDEVDPE MPYLEAFPTD TDVWDENWVF
810 820 830 840 850
SDGAGGSNTT PTIPKVETQK QENKISKEQK QPFKFCMDSG DASVVHRPLE
860 870 880 890 900
EFYISLIKSS KSQESTDIQQ SSHTEEQHLA EKSHRCTAEQ LQGGSSSSML
910 920 930 940 950
CEKKLYYENK DLTYCQQQSK CSFSPLIGFQ KLQIPRSATP AALGPAARLA
960
TAGRLLYWAS DSH
Length:963
Mass (Da):108,146
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4ECEC0157026F17A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC129060 mRNA Translation: AAI29061.1

NCBI Reference Sequences

More...
RefSeqi
NP_001090599.1, NM_001097130.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100036842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:100036842

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129060 mRNA Translation: AAI29061.1
RefSeqiNP_001090599.1, NM_001097130.1

3D structure databases

SMRiA1L1H3
ModBaseiSearch...

Proteomic databases

PRIDEiA1L1H3

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
100036842

Genome annotation databases

GeneIDi100036842
KEGGixla:100036842

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100036842
XenbaseiXB-GENE-5884063, tdrd5.L

Phylogenomic databases

OrthoDBi1115068at2759

Family and domain databases

CDDicd09975, LOTUS_2_TDRD5, 1 hit
cd04508, TUDOR, 1 hit
Gene3Di1.10.10.1880, 3 hits
2.40.50.90, 1 hit
InterProiView protein in InterPro
IPR041966, LOTUS-like
IPR025605, OST-HTH/LOTUS_dom
IPR035437, SNase_OB-fold_sf
IPR037982, TDRD5_LOTUS_2
IPR002999, Tudor
PfamiView protein in Pfam
PF12872, OST-HTH, 3 hits
PF00567, TUDOR, 1 hit
PROSITEiView protein in PROSITE
PS51644, HTH_OST, 3 hits
PS50304, TUDOR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD5_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L1H3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 6, 2007
Last modified: June 2, 2021
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again