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Protein

Epithelial splicing regulatory protein 1

Gene

esrp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-DRE-6803529 FGFR2 alternative splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial splicing regulatory protein 1
Alternative name(s):
RNA-binding motif protein 35A
RNA-binding protein 35A
Gene namesi
Name:esrp1
Synonyms:rbm35a
ORF Names:zgc:154050
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-070112-1732 esrp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002823491 – 714Epithelial splicing regulatory protein 1Add BLAST714

Proteomic databases

PaxDbiA1L1G1
PeptideAtlasiA1L1G1

Expressioni

Gene expression databases

BgeeiENSDARG00000011245 Expressed in 14 organ(s), highest expression level in zone of skin

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094207

Structurei

3D structure databases

ProteinModelPortaliA1L1G1
SMRiA1L1G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 302RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini326 – 406RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini450 – 530RRM 3PROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the ESRP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1365 Eukaryota
ENOG410XPZU LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000112401
InParanoidiA1L1G1
KOiK14947
OrthoDBiEOG091G06HY
PhylomeDBiA1L1G1
TreeFamiTF316157

Family and domain databases

CDDicd12736 RRM1_ESRP1, 1 hit
Gene3Di3.30.420.10, 1 hit
3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034427 ESRP1_RRM1
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SM00360 RRM, 3 hits
SUPFAMiSSF53098 SSF53098, 1 hit
SSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

A1L1G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVNPDYLVL LFTTTSGASG DKLGSDEKEI VQLVWQVVDL ATKKAGQVNE
60 70 80 90 100
LLVKPDHIEL SEECQELSGL TDEALTPVDP LEVAIDQLNQ RLCAEVDTGA
110 120 130 140 150
GNTFYLCTDG QLHVRQVLHP EASSKNILLP DCFFSFFDLR KEFKKEFPSE
160 170 180 190 200
VKLKDLNLQV MADHLNVAVD SSLHAFTAYK VQQMVDIVLA LISEPTCHEF
210 220 230 240 250
TFPEKVNEKF ETGTCSKMER VDDNTVIRAR GLPWQSSDQD IARFFRGLNI
260 270 280 290 300
AKGGAALCLN AQGRRNGEAL VRFESEEHRD LALQRHKHHM GGRYIEVYKA
310 320 330 340 350
TGEDFLKIAG GTSNEVASFL SRENQIIVRM RGLPFNATAE QVLQFFSPAC
360 370 380 390 400
PVTDGSEGIL FVRFPDGRPT GDAFVLFSCE EHAQNALKKH KDMLGKRYIE
410 420 430 440 450
LFKSTAAEVQ QVLNKYSSAP LIPVAPSPIL SVVAPPTFVP QTAAVPGVRD
460 470 480 490 500
CVRLRGLPYD ASIQDILVFL GEYGADIKTH GVHMVLNHQG RPSGEAFIQM
510 520 530 540 550
RSAERAFLAA QRCHKRSMKE RYVEVFACSA QEVNIVLMGG TLNRSGLSPP
560 570 580 590 600
PCLSPPSYTF PHGAPVLPAG AVLPAGAVLP VESAGIYPSQ FLLGPRPPPH
610 620 630 640 650
TTTFYPASNT LYMNYTTYYP SPPGSPSNIS YFPTGHTPSA GSVLSAQPTA
660 670 680 690 700
LIRMQGHAHS HAYNNGVKEI LSMVQGYQPG NSDAFVTFPS MLSAKQPIGD
710
QTVGGGAYLD LQLL
Length:714
Mass (Da):78,136
Last modified:February 6, 2007 - v1
Checksum:i1957B95BC0FB300E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129044 mRNA Translation: AAI29045.1
BC134218 mRNA Translation: AAI34219.1
RefSeqiNP_001074045.1, NM_001080576.1
UniGeneiDr.13001

Genome annotation databases

EnsembliENSDART00000103431; ENSDARP00000094207; ENSDARG00000011245
GeneIDi560190
KEGGidre:560190

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129044 mRNA Translation: AAI29045.1
BC134218 mRNA Translation: AAI34219.1
RefSeqiNP_001074045.1, NM_001080576.1
UniGeneiDr.13001

3D structure databases

ProteinModelPortaliA1L1G1
SMRiA1L1G1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094207

Proteomic databases

PaxDbiA1L1G1
PeptideAtlasiA1L1G1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000103431; ENSDARP00000094207; ENSDARG00000011245
GeneIDi560190
KEGGidre:560190

Organism-specific databases

CTDi54845
ZFINiZDB-GENE-070112-1732 esrp1

Phylogenomic databases

eggNOGiKOG1365 Eukaryota
ENOG410XPZU LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000112401
InParanoidiA1L1G1
KOiK14947
OrthoDBiEOG091G06HY
PhylomeDBiA1L1G1
TreeFamiTF316157

Enzyme and pathway databases

ReactomeiR-DRE-6803529 FGFR2 alternative splicing

Miscellaneous databases

PROiPR:A1L1G1

Gene expression databases

BgeeiENSDARG00000011245 Expressed in 14 organ(s), highest expression level in zone of skin

Family and domain databases

CDDicd12736 RRM1_ESRP1, 1 hit
Gene3Di3.30.420.10, 1 hit
3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034427 ESRP1_RRM1
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SM00360 RRM, 3 hits
SUPFAMiSSF53098 SSF53098, 1 hit
SSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiESRP1_DANRE
AccessioniPrimary (citable) accession number: A1L1G1
Secondary accession number(s): A4FVM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 6, 2007
Last modified: October 10, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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