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Entry version 76 (12 Aug 2020)
Sequence version 1 (06 Feb 2007)
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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

pds5a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-2467813, Separation of Sister Chromatids
R-DRE-2468052, Establishment of Sister Chromatid Cohesion
R-DRE-2470946, Cohesin Loading onto Chromatin
R-DRE-2500257, Resolution of Sister Chromatid Cohesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pds5aBy similarity
ORF Names:zgc:66331
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040426-1612, pds5a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002963451 – 1320Sister chromatid cohesion protein PDS5 homolog AAdd BLAST1320

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L1F4

PeptideAtlas

More...
PeptideAtlasi
A1L1F4

PRoteomics IDEntifications database

More...
PRIDEi
A1L1F4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cohesin complex. Binds chromatin in a cohesin-dependent manner (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000109877

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L1F4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati156 – 195HEAT 1Sequence analysisAdd BLAST40
Repeati272 – 310HEAT 2Sequence analysisAdd BLAST39
Repeati388 – 426HEAT 3Sequence analysisAdd BLAST39
Repeati709 – 747HEAT 4Sequence analysisAdd BLAST39
Repeati990 – 1028HEAT 5Sequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1525, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L1F4

KEGG Orthology (KO)

More...
KOi
K11267

Database of Orthologous Groups

More...
OrthoDBi
69768at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L1F4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR039776, Pds5

The PANTHER Classification System

More...
PANTHERi
PTHR12663, PTHR12663, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A1L1F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFPQQPQQQ RPAGDGKITY PLGVKEITDK ISNDEVVKRL KLVVKTYMDM
60 70 80 90 100
DQDSEEEKQQ YLALALHLAS EFFLRNPNKD VRLLVACCLA DIFRIYAPEA
110 120 130 140 150
PYTSHDKLKE IFLFITRQLK GLEDTKSPQF NRYFYLLENL AWVKSYNICF
160 170 180 190 200
ELEDCNEIFI QLFKTLFSVI NNSHNQKVQM HMLDLMSSII MEGDGVTQEL
210 220 230 240 250
LDTILINLIP AHKNLNKQAY DLARTLLKRT VQTIETCIAS FFNQVLVMGK
260 270 280 290 300
SSVSDLSEHV FDLIQELFAI DPLLLVSVMP QLEFKLKSND GEERLAVVKL
310 320 330 340 350
LAKLFGAKDS ELATQNRPLW QCFLGRFNDI HVPVRLECVK FASHCLMNHP
360 370 380 390 400
DLAKDLTEFL KVRSHDPEEA IRHDVIVTII NAGKKDLNLV NDQLLGFVRE
410 420 430 440 450
RMLDKRWRVR KEAMMGLAQL FKKYCLHHEA GKESALKISW IKDKLLHIYY
460 470 480 490 500
QNSIDDKLLV EKIFAQYMVP HSLETEEKMK CLYYLYACLD TNAVKALNEM
510 520 530 540 550
WKCQNMLRGL VRELLDLHKL PTSEANTSAM FGKLMTIAKN LPDPGKAQDF
560 570 580 590 600
MKKFNQVLGE DEKLRLQLEQ LISPTCSCKQ AEQCVREITR KLTFPKQPTN
610 620 630 640 650
PFLEMVKFLL ERIAPVHIDS EAISALVKLL NKSIEGTADD EDEGVTPDTA
660 670 680 690 700
IRAGLELLKV LSFTHPTAFH SAETYESLLQ CLKMEDDKVA EAAIQIFRNT
710 720 730 740 750
GQKIETELPQ IRSTLIPILH QKAKRGTPHQ AKQAVHCIHA IFHNKEVQLA
760 770 780 790 800
QIFEPLSRSL NADVPEQLIT PLVSLGHISM LAPDQFASPM KSIVANFIVK
810 820 830 840 850
DLLMNDRSVG NKNGRLWTAD DEVSPEVLAK VQAIKLLVRW LLGMKNNQSK
860 870 880 890 900
SANSTLRLPS AMLVSEGDLT EQKKISKSDM SRLRLAAGSA ILKLAQEPCY
910 920 930 940 950
HDIITPEQFQ LCGLVINDEC YQVRQIYAQK LHVALVKLLL PLEYMAVFAL
960 970 980 990 1000
CAKDPVKERR AHARQCLLKN ISVRREYIKQ NPMAHEKLLS LLPEYVVPYM
1010 1020 1030 1040 1050
IHLLAHDPDL TKPQDLEQLR DVKECLWFML EVLMTKNENN SHSFLRKMVE
1060 1070 1080 1090 1100
NIKQTKDAQC PDDPKANEKL YIVCDVALFV IANKSTSCHL DSPKDPVLPS
1110 1120 1130 1140 1150
KFYTPPDKEF VNDKEYLSAE AKIVLQTGKI QQPPKQTGVL GAVNKPLTVT
1160 1170 1180 1190 1200
ARRPYIKTFT SETGSNASTN SQPSSPATNK SRDVSSEVGA RENEENPVIT
1210 1220 1230 1240 1250
KAVSVKKEEA AQPSGRKRAA PASDGTENSV SSNPSAGSQP PLNKPRRGRP
1260 1270 1280 1290 1300
PKNSAGAATQ EKEAGATTGA GAGRGRKRAA PSQDPSSTAS TDALSDKTPK
1310 1320
QQKEAEPKRA APQRQIDLQR
Length:1,320
Mass (Da):148,958
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5FB528659C4129E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QDE7F1QDE7_DANRE
Sister chromatid cohesion protein P...
pds5a
1,321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IU07A0A0R4IU07_DANRE
Sister chromatid cohesion protein P...
pds5a
1,410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1RC71F1RC71_DANRE
Sister chromatid cohesion protein P...
pds5a
442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QD11E9QD11_DANRE
Sister chromatid cohesion protein P...
pds5a
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC129035 mRNA Translation: AAI29036.1

NCBI Reference Sequences

More...
RefSeqi
NP_957286.2, NM_200992.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
393967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:393967

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129035 mRNA Translation: AAI29036.1
RefSeqiNP_957286.2, NM_200992.2

3D structure databases

SMRiA1L1F4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109877

Proteomic databases

PaxDbiA1L1F4
PeptideAtlasiA1L1F4
PRIDEiA1L1F4

Genome annotation databases

GeneIDi393967
KEGGidre:393967

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23244
ZFINiZDB-GENE-040426-1612, pds5a

Phylogenomic databases

eggNOGiKOG1525, Eukaryota
InParanoidiA1L1F4
KOiK11267
OrthoDBi69768at2759
PhylomeDBiA1L1F4

Enzyme and pathway databases

ReactomeiR-DRE-2467813, Separation of Sister Chromatids
R-DRE-2468052, Establishment of Sister Chromatid Cohesion
R-DRE-2470946, Cohesin Loading onto Chromatin
R-DRE-2500257, Resolution of Sister Chromatid Cohesion

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A1L1F4

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR039776, Pds5
PANTHERiPTHR12663, PTHR12663, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDS5A_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L1F4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 6, 2007
Last modified: August 12, 2020
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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