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Protein

Immunoglobulin superfamily member 23

Gene

IGSF23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 23
Gene namesi
Name:IGSF23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000216588.8
HGNCiHGNC:40040 IGSF23
neXtProtiNX_A1L1A6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000216588

Polymorphism and mutation databases

BioMutaiIGSF23

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004107721 – 192Immunoglobulin superfamily member 23Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1L1A6
PRIDEiA1L1A6
ProteomicsDBi138

Expressioni

Gene expression databases

BgeeiENSG00000216588 Expressed in 67 organ(s), highest expression level in liver
ExpressionAtlasiA1L1A6 baseline and differential

Organism-specific databases

HPAiHPA051811
HPA054591

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385592

Structurei

3D structure databases

ProteinModelPortaliA1L1A6
SMRiA1L1A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 128Ig-likeAdd BLAST109

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J23I Eukaryota
ENOG41118KY LUCA
GeneTreeiENSGT00390000015308
HOGENOMiHOG000172210
HOVERGENiHBG076717
InParanoidiA1L1A6
TreeFamiTF339455

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

A1L1A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAKPQSPLP RNPVPAWSPP TTTTDPMLEK DAAGGDFPAN LVLQLMPLKT
60 70 80 90 100
FPAAIRGVIQ SELNYSVILQ WVVTMDPEPV LSWTFSGVPC GMGEKLFIRR
110 120 130 140 150
LSCEQLGTYM CIATNSKKQL VSEPVTISLP KPIMQPTEAE PMEPDPTLSL
160 170 180 190
SGGSAIGLLA AGILGAGALI AGMCFIIIQS LRTDRQRIGI CS
Length:192
Mass (Da):20,591
Last modified:June 28, 2011 - v2
Checksum:i0B965768293F6B37
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y773H0Y773_HUMAN
Immunoglobulin superfamily member 2...
IGSF23
212Annotation score:
H0Y6S3H0Y6S3_HUMAN
Immunoglobulin superfamily member 2...
IGSF23
138Annotation score:
K7EL25K7EL25_HUMAN
Immunoglobulin superfamily member 2...
IGSF23
66Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138472 Genomic DNA No translation available.
BC127928 mRNA Translation: AAI27929.1
BC127929 mRNA Translation: AAI27930.1
CCDSiCCDS54277.1
RefSeqiNP_001192209.1, NM_001205280.1
UniGeneiHs.512509

Genome annotation databases

EnsembliENST00000402988; ENSP00000385592; ENSG00000216588
GeneIDi147710
KEGGihsa:147710
UCSCiuc021uvj.1 human

Similar proteinsi

Entry informationi

Entry nameiIGS23_HUMAN
AccessioniPrimary (citable) accession number: A1L1A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 12, 2018
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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