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UniProtKB - A1L1A6 (IGS23_HUMAN)
Protein
Immunoglobulin superfamily member 23
Gene
IGSF23
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin superfamily member 23 |
Gene namesi | Name:IGSF23 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:40040, IGSF23 |
neXtProti | NX_A1L1A6 |
VEuPathDBi | HostDB:ENSG00000216588 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 147710 |
OpenTargetsi | ENSG00000216588 |
Miscellaneous databases
Pharosi | A1L1A6, Tdark |
Genetic variation databases
BioMutai | IGSF23 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000410772 | 1 – 192 | Immunoglobulin superfamily member 23Add BLAST | 192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 64 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | A1L1A6 |
MassIVEi | A1L1A6 |
PaxDbi | A1L1A6 |
PeptideAtlasi | A1L1A6 |
PRIDEi | A1L1A6 |
PTM databases
GlyGeni | A1L1A6, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSG00000216588, Expressed in right lobe of liver and 88 other tissues |
ExpressionAtlasi | A1L1A6, baseline and differential |
Organism-specific databases
HPAi | ENSG00000216588, Group enriched (intestine, liver) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000385592 |
Miscellaneous databases
RNActi | A1L1A6, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 128 | Ig-likeAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 |
Keywords - Domaini
Immunoglobulin domain, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU2R, Eukaryota |
GeneTreei | ENSGT00390000015308 |
InParanoidi | A1L1A6 |
OMAi | MRAKPQS |
OrthoDBi | 1362674at2759 |
TreeFami | TF339455 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A1L1A6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAKPQSPLP RNPVPAWSPP TTTTDPMLEK DAAGGDFPAN LVLQLMPLKT
60 70 80 90 100
FPAAIRGVIQ SELNYSVILQ WVVTMDPEPV LSWTFSGVPC GMGEKLFIRR
110 120 130 140 150
LSCEQLGTYM CIATNSKKQL VSEPVTISLP KPIMQPTEAE PMEPDPTLSL
160 170 180 190
SGGSAIGLLA AGILGAGALI AGMCFIIIQS LRTDRQRIGI CS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y773 | H0Y773_HUMAN | Immunoglobulin superfamily member 2... | IGSF23 | 212 | Annotation score: | ||
H0Y6S3 | H0Y6S3_HUMAN | Immunoglobulin superfamily member 2... | IGSF23 | 138 | Annotation score: | ||
K7EL25 | K7EL25_HUMAN | Immunoglobulin superfamily member 2... | IGSF23 | 66 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC138472 Genomic DNA No translation available. BC127928 mRNA Translation: AAI27929.1 BC127929 mRNA Translation: AAI27930.1 |
CCDSi | CCDS54277.1 |
RefSeqi | NP_001192209.1, NM_001205280.1 |
Genome annotation databases
Ensembli | ENST00000402988; ENSP00000385592; ENSG00000216588 |
GeneIDi | 147710 |
KEGGi | hsa:147710 |
MANE-Selecti | ENST00000402988.6; ENSP00000385592.1; NM_001205280.2; NP_001192209.1 |
UCSCi | uc021uvj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC138472 Genomic DNA No translation available. BC127928 mRNA Translation: AAI27929.1 BC127929 mRNA Translation: AAI27930.1 |
CCDSi | CCDS54277.1 |
RefSeqi | NP_001192209.1, NM_001205280.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000385592 |
PTM databases
GlyGeni | A1L1A6, 1 site |
Genetic variation databases
BioMutai | IGSF23 |
Proteomic databases
jPOSTi | A1L1A6 |
MassIVEi | A1L1A6 |
PaxDbi | A1L1A6 |
PeptideAtlasi | A1L1A6 |
PRIDEi | A1L1A6 |
Protocols and materials databases
Antibodypediai | 70970, 8 antibodies from 4 providers |
DNASUi | 147710 |
Genome annotation databases
Ensembli | ENST00000402988; ENSP00000385592; ENSG00000216588 |
GeneIDi | 147710 |
KEGGi | hsa:147710 |
MANE-Selecti | ENST00000402988.6; ENSP00000385592.1; NM_001205280.2; NP_001192209.1 |
UCSCi | uc021uvj.1, human |
Organism-specific databases
CTDi | 147710 |
DisGeNETi | 147710 |
GeneCardsi | IGSF23 |
HGNCi | HGNC:40040, IGSF23 |
HPAi | ENSG00000216588, Group enriched (intestine, liver) |
neXtProti | NX_A1L1A6 |
OpenTargetsi | ENSG00000216588 |
VEuPathDBi | HostDB:ENSG00000216588 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU2R, Eukaryota |
GeneTreei | ENSGT00390000015308 |
InParanoidi | A1L1A6 |
OMAi | MRAKPQS |
OrthoDBi | 1362674at2759 |
TreeFami | TF339455 |
Enzyme and pathway databases
PathwayCommonsi | A1L1A6 |
SignaLinki | A1L1A6 |
Miscellaneous databases
BioGRID-ORCSi | 147710, 5 hits in 1035 CRISPR screens |
ChiTaRSi | IGSF23, human |
GenomeRNAii | 147710 |
Pharosi | A1L1A6, Tdark |
PROi | PR:A1L1A6 |
RNActi | A1L1A6, protein |
Gene expression databases
Bgeei | ENSG00000216588, Expressed in right lobe of liver and 88 other tissues |
ExpressionAtlasi | A1L1A6, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IGS23_HUMAN | |
Accessioni | A1L1A6Primary (citable) accession number: A1L1A6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM