UniProtKB - A1L190 (SYCE3_HUMAN)
Protein
Synaptonemal complex central element protein 3
Gene
SYCE3
Organism
Homo sapiens (Human)
Status
Functioni
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.By similarity
GO - Biological processi
- cell division Source: UniProtKB-KW
- positive regulation of apoptotic process Source: Ensembl
- reciprocal meiotic recombination Source: UniProtKB
- spermatogenesis Source: UniProtKB
- synaptonemal complex assembly Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Meiosis |
Enzyme and pathway databases
PathwayCommonsi | A1L190 |
Reactomei | R-HSA-1221632, Meiotic synapsis |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptonemal complex central element protein 3Alternative name(s): Testis highly expressed gene 2 protein Short name: THEG-2 |
Gene namesi | Name:SYCE3 Synonyms:C22orf41, THEG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:35245, SYCE3 |
MIMi | 615775, gene |
neXtProti | NX_A1L190 |
VEuPathDBi | HostDB:ENSG00000217442.3 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Note: Colocalizes with SYCE1 in the central elements.By similarity
Nucleus
- central element Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 644186 |
OpenTargetsi | ENSG00000217442 |
PharmGKBi | PA164717081 |
Miscellaneous databases
Pharosi | A1L190, Tdark |
Genetic variation databases
BioMutai | SYCE3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367274 | 1 – 88 | Synaptonemal complex central element protein 3Add BLAST | 88 |
Proteomic databases
MaxQBi | A1L190 |
PaxDbi | A1L190 |
PeptideAtlasi | A1L190 |
PRIDEi | A1L190 |
ProteomicsDBi | 137 |
PTM databases
iPTMneti | A1L190 |
PhosphoSitePlusi | A1L190 |
Expressioni
Gene expression databases
Bgeei | ENSG00000217442, Expressed in testis and 133 other tissues |
Genevisiblei | A1L190, HS |
Organism-specific databases
HPAi | ENSG00000217442, Tissue enriched (testis) |
Interactioni
Subunit structurei
Homodimer.
Interacts with SYCE1.
Interacts with SYCE2.
Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity).
Interacts with SPO16 (By similarity).
By similarityBinary interactionsi
Hide detailsA1L190
Protein-protein interaction databases
BioGRIDi | 569383, 57 interactors |
IntActi | A1L190, 52 interactors |
STRINGi | 9606.ENSP00000385480 |
Miscellaneous databases
RNActi | A1L190, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 7 – 75 | Sequence analysisAdd BLAST | 69 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S4TF, Eukaryota |
GeneTreei | ENSGT00390000009978 |
HOGENOMi | CLU_2548975_0_0_1 |
InParanoidi | A1L190 |
OMAi | MVVIRTN |
OrthoDBi | 1545114at2759 |
PhylomeDBi | A1L190 |
Family and domain databases
InterProi | View protein in InterPro IPR028145, Synaptonemal_3 |
PANTHERi | PTHR36686, PTHR36686, 1 hit |
Pfami | View protein in Pfam PF15191, Synaptonemal_3, 1 hit |
i Sequence
Sequence statusi: Complete.
A1L190-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR
60 70 80
TNPTLAESMR RLEDAFVNCK EEMEKNWQEL LHETKQRL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060126 | 88 | L → P. Corresponds to variant dbSNP:rs6009989Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU082028 mRNA Translation: ABU52998.1 CH471138 Genomic DNA Translation: EAW73567.1 BC127859 mRNA Translation: AAI27860.1 BC127860 mRNA Translation: AAI27861.1 |
CCDSi | CCDS46733.1 |
RefSeqi | NP_001116697.1, NM_001123225.2 |
Genome annotation databases
Ensembli | ENST00000402753; ENSP00000385122; ENSG00000217442 ENST00000406915; ENSP00000385480; ENSG00000217442 |
GeneIDi | 644186 |
KEGGi | hsa:644186 |
UCSCi | uc003bmj.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU082028 mRNA Translation: ABU52998.1 CH471138 Genomic DNA Translation: EAW73567.1 BC127859 mRNA Translation: AAI27860.1 BC127860 mRNA Translation: AAI27861.1 |
CCDSi | CCDS46733.1 |
RefSeqi | NP_001116697.1, NM_001123225.2 |
3D structure databases
SMRi | A1L190 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 569383, 57 interactors |
IntActi | A1L190, 52 interactors |
STRINGi | 9606.ENSP00000385480 |
PTM databases
iPTMneti | A1L190 |
PhosphoSitePlusi | A1L190 |
Genetic variation databases
BioMutai | SYCE3 |
Proteomic databases
MaxQBi | A1L190 |
PaxDbi | A1L190 |
PeptideAtlasi | A1L190 |
PRIDEi | A1L190 |
ProteomicsDBi | 137 |
Protocols and materials databases
Antibodypediai | 62384, 6 antibodies |
Genome annotation databases
Ensembli | ENST00000402753; ENSP00000385122; ENSG00000217442 ENST00000406915; ENSP00000385480; ENSG00000217442 |
GeneIDi | 644186 |
KEGGi | hsa:644186 |
UCSCi | uc003bmj.5, human |
Organism-specific databases
CTDi | 644186 |
DisGeNETi | 644186 |
GeneCardsi | SYCE3 |
HGNCi | HGNC:35245, SYCE3 |
HPAi | ENSG00000217442, Tissue enriched (testis) |
MIMi | 615775, gene |
neXtProti | NX_A1L190 |
OpenTargetsi | ENSG00000217442 |
PharmGKBi | PA164717081 |
VEuPathDBi | HostDB:ENSG00000217442.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4TF, Eukaryota |
GeneTreei | ENSGT00390000009978 |
HOGENOMi | CLU_2548975_0_0_1 |
InParanoidi | A1L190 |
OMAi | MVVIRTN |
OrthoDBi | 1545114at2759 |
PhylomeDBi | A1L190 |
Enzyme and pathway databases
PathwayCommonsi | A1L190 |
Reactomei | R-HSA-1221632, Meiotic synapsis |
Miscellaneous databases
BioGRID-ORCSi | 644186, 6 hits in 982 CRISPR screens |
ChiTaRSi | SYCE3, human |
GenomeRNAii | 644186 |
Pharosi | A1L190, Tdark |
PROi | PR:A1L190 |
RNActi | A1L190, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000217442, Expressed in testis and 133 other tissues |
Genevisiblei | A1L190, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028145, Synaptonemal_3 |
PANTHERi | PTHR36686, PTHR36686, 1 hit |
Pfami | View protein in Pfam PF15191, Synaptonemal_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYCE3_HUMAN | |
Accessioni | A1L190Primary (citable) accession number: A1L190 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | February 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot