UniProtKB - A1L190 (SYCE3_HUMAN)
Synaptonemal complex central element protein 3
SYCE3
Functioni
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.
By similarityGO - Biological processi
- cell division Source: UniProtKB-KW
- positive regulation of apoptotic process Source: Ensembl
- reciprocal meiotic recombination Source: UniProtKB
- spermatogenesis Source: UniProtKB
- synaptonemal complex assembly Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Cell division, Meiosis |
Enzyme and pathway databases
PathwayCommonsi | A1L190 |
Reactomei | R-HSA-1221632, Meiotic synapsis |
SignaLinki | A1L190 |
SIGNORi | A1L190 |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptonemal complex central element protein 3Alternative name(s): Testis highly expressed gene 2 protein Short name: THEG-2 |
Gene namesi | Name:SYCE3 Synonyms:C22orf41, THEG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:35245, SYCE3 |
MIMi | 615775, gene |
neXtProti | NX_A1L190 |
VEuPathDBi | HostDB:ENSG00000217442 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Note: Colocalizes with SYCE1 in the central elements.By similarity
Nucleus
- central element Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 644186 |
OpenTargetsi | ENSG00000217442 |
PharmGKBi | PA164717081 |
Miscellaneous databases
Pharosi | A1L190, Tdark |
Genetic variation databases
BioMutai | SYCE3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367274 | 1 – 88 | Synaptonemal complex central element protein 3Add BLAST | 88 |
Proteomic databases
MassIVEi | A1L190 |
MaxQBi | A1L190 |
PaxDbi | A1L190 |
PeptideAtlasi | A1L190 |
PRIDEi | A1L190 |
ProteomicsDBi | 137 |
PTM databases
iPTMneti | A1L190 |
PhosphoSitePlusi | A1L190 |
Expressioni
Gene expression databases
Bgeei | ENSG00000217442, Expressed in testis and 133 other tissues |
Genevisiblei | A1L190, HS |
Organism-specific databases
HPAi | ENSG00000217442, Tissue enriched (testis) |
Interactioni
Subunit structurei
Homodimer.
Interacts with SYCE1.
Interacts with SYCE2.
Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity).
Interacts with SPO16 (By similarity).
By similarityBinary interactionsi
A1L190
Protein-protein interaction databases
BioGRIDi | 569383, 59 interactors |
IntActi | A1L190, 52 interactors |
STRINGi | 9606.ENSP00000385480 |
Miscellaneous databases
RNActi | A1L190, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 7 – 75 | Sequence analysisAdd BLAST | 69 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S4TF, Eukaryota |
GeneTreei | ENSGT00390000009978 |
HOGENOMi | CLU_2548975_0_0_1 |
InParanoidi | A1L190 |
OMAi | MVVIRTN |
OrthoDBi | 1545114at2759 |
PhylomeDBi | A1L190 |
Family and domain databases
InterProi | View protein in InterPro IPR028145, Synaptonemal_3 |
PANTHERi | PTHR36686, PTHR36686, 1 hit |
Pfami | View protein in Pfam PF15191, Synaptonemal_3, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR
60 70 80
TNPTLAESMR RLEDAFVNCK EEMEKNWQEL LHETKQRL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060126 | 88 | L → P. Corresponds to variant dbSNP:rs6009989Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU082028 mRNA Translation: ABU52998.1 CH471138 Genomic DNA Translation: EAW73567.1 BC127859 mRNA Translation: AAI27860.1 BC127860 mRNA Translation: AAI27861.1 |
CCDSi | CCDS46733.1 |
RefSeqi | NP_001116697.1, NM_001123225.2 |
Genome annotation databases
Ensembli | ENST00000402753; ENSP00000385122; ENSG00000217442 ENST00000406915; ENSP00000385480; ENSG00000217442 |
GeneIDi | 644186 |
KEGGi | hsa:644186 |
MANE-Selecti | ENST00000406915.4; ENSP00000385480.3; NM_001123225.3; NP_001116697.1 |
UCSCi | uc003bmj.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU082028 mRNA Translation: ABU52998.1 CH471138 Genomic DNA Translation: EAW73567.1 BC127859 mRNA Translation: AAI27860.1 BC127860 mRNA Translation: AAI27861.1 |
CCDSi | CCDS46733.1 |
RefSeqi | NP_001116697.1, NM_001123225.2 |
3D structure databases
SMRi | A1L190 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 569383, 59 interactors |
IntActi | A1L190, 52 interactors |
STRINGi | 9606.ENSP00000385480 |
PTM databases
iPTMneti | A1L190 |
PhosphoSitePlusi | A1L190 |
Genetic variation databases
BioMutai | SYCE3 |
Proteomic databases
MassIVEi | A1L190 |
MaxQBi | A1L190 |
PaxDbi | A1L190 |
PeptideAtlasi | A1L190 |
PRIDEi | A1L190 |
ProteomicsDBi | 137 |
Protocols and materials databases
Antibodypediai | 62384, 11 antibodies from 7 providers |
DNASUi | 644186 |
Genome annotation databases
Ensembli | ENST00000402753; ENSP00000385122; ENSG00000217442 ENST00000406915; ENSP00000385480; ENSG00000217442 |
GeneIDi | 644186 |
KEGGi | hsa:644186 |
MANE-Selecti | ENST00000406915.4; ENSP00000385480.3; NM_001123225.3; NP_001116697.1 |
UCSCi | uc003bmj.5, human |
Organism-specific databases
CTDi | 644186 |
DisGeNETi | 644186 |
GeneCardsi | SYCE3 |
HGNCi | HGNC:35245, SYCE3 |
HPAi | ENSG00000217442, Tissue enriched (testis) |
MIMi | 615775, gene |
neXtProti | NX_A1L190 |
OpenTargetsi | ENSG00000217442 |
PharmGKBi | PA164717081 |
VEuPathDBi | HostDB:ENSG00000217442 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4TF, Eukaryota |
GeneTreei | ENSGT00390000009978 |
HOGENOMi | CLU_2548975_0_0_1 |
InParanoidi | A1L190 |
OMAi | MVVIRTN |
OrthoDBi | 1545114at2759 |
PhylomeDBi | A1L190 |
Enzyme and pathway databases
PathwayCommonsi | A1L190 |
Reactomei | R-HSA-1221632, Meiotic synapsis |
SignaLinki | A1L190 |
SIGNORi | A1L190 |
Miscellaneous databases
BioGRID-ORCSi | 644186, 8 hits in 1034 CRISPR screens |
ChiTaRSi | SYCE3, human |
GenomeRNAii | 644186 |
Pharosi | A1L190, Tdark |
PROi | PR:A1L190 |
RNActi | A1L190, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000217442, Expressed in testis and 133 other tissues |
Genevisiblei | A1L190, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028145, Synaptonemal_3 |
PANTHERi | PTHR36686, PTHR36686, 1 hit |
Pfami | View protein in Pfam PF15191, Synaptonemal_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYCE3_HUMAN | |
Accessioni | A1L190Primary (citable) accession number: A1L190 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot