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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

Gene

NDUFAF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) (PubMed:27499296). Required to stabilize NDUFAF5 (PubMed:27499296).1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8Imported
Gene namesi
Name:NDUFAF8Imported
Synonyms:C17orf89Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000224877.3
HGNCiHGNC:33551 NDUFAF8
neXtProtiNX_A1L188

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000224877
PharmGKBiPA162378532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994801 – 74NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 61PROSITE-ProRule annotation
Disulfide bondi35 ↔ 51PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiA1L188
MaxQBiA1L188
PaxDbiA1L188
PRIDEiA1L188
ProteomicsDBi136

PTM databases

iPTMnetiA1L188
PhosphoSitePlusiA1L188

Expressioni

Gene expression databases

BgeeiENSG00000224877 Expressed in 202 organ(s), highest expression level in quadriceps femoris
CleanExiHS_C17orf89
ExpressionAtlasiA1L188 baseline and differential
GenevisibleiA1L188 HS

Organism-specific databases

HPAiHPA057732

Interactioni

Subunit structurei

Interacts with NDUFAF5.1 Publication

Protein-protein interaction databases

BioGridi129780, 39 interactors
IntActiA1L188, 119 interactors
STRINGi9606.ENSP00000400184

Structurei

3D structure databases

ProteinModelPortaliA1L188
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 69CHCHPROSITE-ProRule annotationAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi25 – 35Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi51 – 61Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Phylogenomic databases

eggNOGiENOG410J7SE Eukaryota
ENOG410Y78Q LUCA
GeneTreeiENSGT00520000061927
HOGENOMiHOG000060278
HOVERGENiHBG089736
InParanoidiA1L188
OMAiLCAQEFE
PhylomeDBiA1L188

Family and domain databases

InterProiView protein in InterPro
IPR034595 NDUFAF8
PANTHERiPTHR34561 PTHR34561, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1L188-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSANGAVWGR VRSRLRAFPE RLAACGAEAA AYGRCVQAST APGGRLSKDF
60 70
CAREFEALRS CFAAAAKKTL EGGC
Length:74
Mass (Da):7,756
Last modified:February 20, 2007 - v1
Checksum:iF3FCE21C67A3979F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4C8I3L4C8_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFAF8
79Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471099 Genomic DNA Translation: EAW89640.1
BC127837 mRNA Translation: AAI27838.1
CCDSiCCDS45809.1
RefSeqiNP_001079990.1, NM_001086521.1
UniGeneiHs.356545

Genome annotation databases

EnsembliENST00000431388; ENSP00000400184; ENSG00000224877
GeneIDi284184
KEGGihsa:284184
UCSCiuc002jzx.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471099 Genomic DNA Translation: EAW89640.1
BC127837 mRNA Translation: AAI27838.1
CCDSiCCDS45809.1
RefSeqiNP_001079990.1, NM_001086521.1
UniGeneiHs.356545

3D structure databases

ProteinModelPortaliA1L188
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129780, 39 interactors
IntActiA1L188, 119 interactors
STRINGi9606.ENSP00000400184

PTM databases

iPTMnetiA1L188
PhosphoSitePlusiA1L188

Proteomic databases

EPDiA1L188
MaxQBiA1L188
PaxDbiA1L188
PRIDEiA1L188
ProteomicsDBi136

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431388; ENSP00000400184; ENSG00000224877
GeneIDi284184
KEGGihsa:284184
UCSCiuc002jzx.3 human

Organism-specific databases

CTDi284184
EuPathDBiHostDB:ENSG00000224877.3
GeneCardsiNDUFAF8
H-InvDBiHIX0039054
HGNCiHGNC:33551 NDUFAF8
HPAiHPA057732
neXtProtiNX_A1L188
OpenTargetsiENSG00000224877
PharmGKBiPA162378532
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J7SE Eukaryota
ENOG410Y78Q LUCA
GeneTreeiENSGT00520000061927
HOGENOMiHOG000060278
HOVERGENiHBG089736
InParanoidiA1L188
OMAiLCAQEFE
PhylomeDBiA1L188

Miscellaneous databases

ChiTaRSiNDUFAF8 human
GenomeRNAii284184
PROiPR:A1L188

Gene expression databases

BgeeiENSG00000224877 Expressed in 202 organ(s), highest expression level in quadriceps femoris
CleanExiHS_C17orf89
ExpressionAtlasiA1L188 baseline and differential
GenevisibleiA1L188 HS

Family and domain databases

InterProiView protein in InterPro
IPR034595 NDUFAF8
PANTHERiPTHR34561 PTHR34561, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUF8_HUMAN
AccessioniPrimary (citable) accession number: A1L188
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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