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Entry version 66 (25 May 2022)
Sequence version 1 (06 Feb 2007)
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Protein

Mediator of RNA polymerase II transcription subunit 1

Gene

med1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 1
Alternative name(s):
Mediator complex subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:med1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020211 – 1573Mediator of RNA polymerase II transcription subunit 1Add BLAST1573

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L0Z0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000051133

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11573
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
A1L0Z0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L0Z0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A1L0Z0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni595 – 691DisorderedSequence analysisAdd BLAST97
Regioni774 – 883DisorderedSequence analysisAdd BLAST110
Regioni928 – 1564DisorderedSequence analysisAdd BLAST637

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi588 – 592LXXLL motif 15
Motifi629 – 633LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi636 – 665Polar residuesSequence analysisAdd BLAST30
Compositional biasi788 – 807Polar residuesSequence analysisAdd BLAST20
Compositional biasi834 – 871Polar residuesSequence analysisAdd BLAST38
Compositional biasi930 – 945Polar residuesSequence analysisAdd BLAST16
Compositional biasi987 – 1013Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1014 – 1044Polar residuesSequence analysisAdd BLAST31
Compositional biasi1062 – 1114Polar residuesSequence analysisAdd BLAST53
Compositional biasi1120 – 1197Polar residuesSequence analysisAdd BLAST78
Compositional biasi1214 – 1298Polar residuesSequence analysisAdd BLAST85
Compositional biasi1347 – 1364Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1421 – 1490Polar residuesSequence analysisAdd BLAST70
Compositional biasi1508 – 1523Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPZ7, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L0Z0

Database of Orthologous Groups

More...
OrthoDBi
57581at2759

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50031

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019680, Mediator_Med1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10744, Med1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1L0Z0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLLERLHS KYSQNRPWPE TIKLVRQIME KRTGMMSGSH QHLVSCLETL
60 70 80 90 100
QKALKVSSLS AMTDRLESIA RQNGLTSHLS PNGTECYITT DMFYLEVLLD
110 120 130 140 150
TEGQLCDVKV AHHRENPVSC PELVEQLREK NFEDFSQHLK GLVNLYKVPG
160 170 180 190 200
DNKLETKMYL ALQSLELDLT KMAAMYWQAT NASVLEKILH GTVGYLTPRS
210 220 230 240 250
GGQVMSLKYY VSPYDLFDDT TGASISLSEG HAVPRSLGMN VSVTIEATSA
260 270 280 290 300
MYKLPIAPLI MGSHPIDNKG TPSFTSITNA NSVDLPACFF LKFPQPIPVS
310 320 330 340 350
RAFIQKIQHC TGIPLIDGSH TFLPHYELVT QFELAKEKEP GTLNHNMRFY
360 370 380 390 400
ASLPGQQHCY FVNKDAPLPD GRSLQGTLLS KIPFQHPGRV PIILSLIRHQ
410 420 430 440 450
VACNTLIGSC VKRTMLKEDC PGLLQFEVAP LSDSCFSISF QHPVNDSLVC
460 470 480 490 500
VVMDVQDSSH VSCKLYKGLS DALICTDDFI TKVVQRCMSI PVTMRAIRRK
510 520 530 540 550
AETIQADTPA LSLIAETVED MVKKNLPPAS SPGYGMASGS TALSGITTPT
560 570 580 590 600
SSYTSGQISS LFNMGIKERH DSAGHGDDFS KVTQNPILTS LLQITSNSGG
610 620 630 640 650
TLGSSPTPPQ HTPPPASSPA SNTKNHPMLM NLLKDNPAQD FSTLYGGSPL
660 670 680 690 700
ERQNSSGSPR TELGSSASGK PKKKRPRTGT EKMKNQTEDD FQRELFSMDV
710 720 730 740 750
DSQNTIFDVG MAGDALDTPH ITPAPSQCGT PPNVYQQAIP HTQANMQRMV
760 770 780 790 800
RIPSTDAIIP DVTDILSDIA EEASKLPGPG EDCPNLGTPV RDSSSSGHSQ
810 820 830 840 850
STLFDTDVFQ VDGGGGSGGE NPYPDPVDLI VDSHGSPNSD SPNTFFNSVD
860 870 880 890 900
FNPDLLNSQS QSGFTDDLND DSSQSGDNDF KDFAGPGLAS LGIVSGLPVD
910 920 930 940 950
GGDGKYKMAL GADTVDFSII AGGGSKNLGG PDIQETQSRS QSPLLGSDLG
960 970 980 990 1000
KDRPQKQKVK ESGNGGGAGG GLSGMQSAGM EGKSMKRSRT PSSDGKSKDK
1010 1020 1030 1040 1050
PPKRKKTESD GKSPSHITNR PFTPPTSTGG SKSPGTSGRS QTPPGMATPP
1060 1070 1080 1090 1100
IPKITIQIPK GTMSVGKPSS HSQYSSSGSS SSSSSKSHHG HSSLSSSASG
1110 1120 1130 1140 1150
KIKSNKSDGS SGMKIGSSGG GMYSGQSGQS NSQSKNSSQS MGKAGSSPIT
1160 1170 1180 1190 1200
KHGLSSNVNN SSGSKTKPQG KPSVLMNPSL SKPNISPSHS RPSGGSDKLS
1210 1220 1230 1240 1250
SPMKPMPGTP PSSKAKSPIG SGGQHLSGSG SNSTTKSSSG LVSSGSLTQK
1260 1270 1280 1290 1300
PNSSSSSSSS SSSSSSSSSS SSSSFSSGVS QNLHSSSKGK SPSRNKKPSL
1310 1320 1330 1340 1350
TAVIDKLKHG VGTGGPGSED PMDGGVGGGS TGAPSHGMSS KHGLGVGEFP
1360 1370 1380 1390 1400
TKREKGEKDK SKGSSGGPSD PSKKGGGDSK GSVSTGVAKI IISKHDGGSP
1410 1420 1430 1440 1450
SIKAKVTLQK PEGGGEGLRS QMQKNYGSPL ISGSTPKHER CSPSHNKSPA
1460 1470 1480 1490 1500
YTPQALDSES ESGSSSIAEK SYQNSPSSDD GGGSGSRAQT EYSAEKHKKH
1510 1520 1530 1540 1550
KKEKKRLKDK DRDREKKKSY TMKPESWSKS PISADPTMAM GGGAMMSSDR
1560 1570
ASRPTPSFLM GDDDDLIDVP LTL
Length:1,573
Mass (Da):165,656
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6386F10B9E8862E8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC127309 mRNA Translation: AAI27310.1

NCBI Reference Sequences

More...
RefSeqi
NP_001090727.1, NM_001097258.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100036710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100036710

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127309 mRNA Translation: AAI27310.1
RefSeqiNP_001090727.1, NM_001097258.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZMHX-ray2.10C624-636[»]
2ZMIX-ray1.70C624-636[»]
2ZMJX-ray2.35C624-636[»]
2ZXMX-ray3.01C624-636[»]
2ZXNX-ray2.10C624-636[»]
3AFRX-ray2.00C624-636[»]
AlphaFoldDBiA1L0Z0
SMRiA1L0Z0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000051133

Proteomic databases

PaxDbiA1L0Z0

Genome annotation databases

GeneIDi100036710
KEGGixtr:100036710

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5469

Phylogenomic databases

eggNOGiENOG502QPZ7, Eukaryota
InParanoidiA1L0Z0
OrthoDBi57581at2759

Miscellaneous databases

EvolutionaryTraceiA1L0Z0

Family and domain databases

IDEALiIID50031
InterProiView protein in InterPro
IPR019680, Mediator_Med1
PfamiView protein in Pfam
PF10744, Med1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED1_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L0Z0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 6, 2007
Last modified: May 25, 2022
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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