UniProtKB - A1L0Z0 (MED1_XENTR)
Mediator of RNA polymerase II transcription subunit 1
med1
Functioni
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
By similarityGO - Molecular functioni
- transcription coregulator activity Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 1Alternative name(s): Mediator complex subunit 1 |
Gene namesi | Name:med1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- mediator complex Source: InterPro
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000302021 | 1 – 1573 | Mediator of RNA polymerase II transcription subunit 1Add BLAST | 1573 |
Proteomic databases
PaxDbi | A1L0Z0 |
Interactioni
Subunit structurei
Component of the Mediator complex.
By similarityProtein-protein interaction databases
STRINGi | 8364.ENSXETP00000051133 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | A1L0Z0 |
SMRi | A1L0Z0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | A1L0Z0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 595 – 691 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 774 – 883 | DisorderedSequence analysisAdd BLAST | 110 | |
Regioni | 928 – 1564 | DisorderedSequence analysisAdd BLAST | 637 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 588 – 592 | LXXLL motif 1 | 5 | |
Motifi | 629 – 633 | LXXLL motif 2 | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 636 – 665 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 788 – 807 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 834 – 871 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 930 – 945 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 987 – 1013 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1014 – 1044 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1062 – 1114 | Polar residuesSequence analysisAdd BLAST | 53 | |
Compositional biasi | 1120 – 1197 | Polar residuesSequence analysisAdd BLAST | 78 | |
Compositional biasi | 1214 – 1298 | Polar residuesSequence analysisAdd BLAST | 85 | |
Compositional biasi | 1347 – 1364 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1421 – 1490 | Polar residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 1508 – 1523 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QPZ7, Eukaryota |
InParanoidi | A1L0Z0 |
OrthoDBi | 57581at2759 |
Family and domain databases
IDEALi | IID50031 |
InterProi | View protein in InterPro IPR019680, Mediator_Med1 |
Pfami | View protein in Pfam PF10744, Med1, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSSLLERLHS KYSQNRPWPE TIKLVRQIME KRTGMMSGSH QHLVSCLETL
60 70 80 90 100
QKALKVSSLS AMTDRLESIA RQNGLTSHLS PNGTECYITT DMFYLEVLLD
110 120 130 140 150
TEGQLCDVKV AHHRENPVSC PELVEQLREK NFEDFSQHLK GLVNLYKVPG
160 170 180 190 200
DNKLETKMYL ALQSLELDLT KMAAMYWQAT NASVLEKILH GTVGYLTPRS
210 220 230 240 250
GGQVMSLKYY VSPYDLFDDT TGASISLSEG HAVPRSLGMN VSVTIEATSA
260 270 280 290 300
MYKLPIAPLI MGSHPIDNKG TPSFTSITNA NSVDLPACFF LKFPQPIPVS
310 320 330 340 350
RAFIQKIQHC TGIPLIDGSH TFLPHYELVT QFELAKEKEP GTLNHNMRFY
360 370 380 390 400
ASLPGQQHCY FVNKDAPLPD GRSLQGTLLS KIPFQHPGRV PIILSLIRHQ
410 420 430 440 450
VACNTLIGSC VKRTMLKEDC PGLLQFEVAP LSDSCFSISF QHPVNDSLVC
460 470 480 490 500
VVMDVQDSSH VSCKLYKGLS DALICTDDFI TKVVQRCMSI PVTMRAIRRK
510 520 530 540 550
AETIQADTPA LSLIAETVED MVKKNLPPAS SPGYGMASGS TALSGITTPT
560 570 580 590 600
SSYTSGQISS LFNMGIKERH DSAGHGDDFS KVTQNPILTS LLQITSNSGG
610 620 630 640 650
TLGSSPTPPQ HTPPPASSPA SNTKNHPMLM NLLKDNPAQD FSTLYGGSPL
660 670 680 690 700
ERQNSSGSPR TELGSSASGK PKKKRPRTGT EKMKNQTEDD FQRELFSMDV
710 720 730 740 750
DSQNTIFDVG MAGDALDTPH ITPAPSQCGT PPNVYQQAIP HTQANMQRMV
760 770 780 790 800
RIPSTDAIIP DVTDILSDIA EEASKLPGPG EDCPNLGTPV RDSSSSGHSQ
810 820 830 840 850
STLFDTDVFQ VDGGGGSGGE NPYPDPVDLI VDSHGSPNSD SPNTFFNSVD
860 870 880 890 900
FNPDLLNSQS QSGFTDDLND DSSQSGDNDF KDFAGPGLAS LGIVSGLPVD
910 920 930 940 950
GGDGKYKMAL GADTVDFSII AGGGSKNLGG PDIQETQSRS QSPLLGSDLG
960 970 980 990 1000
KDRPQKQKVK ESGNGGGAGG GLSGMQSAGM EGKSMKRSRT PSSDGKSKDK
1010 1020 1030 1040 1050
PPKRKKTESD GKSPSHITNR PFTPPTSTGG SKSPGTSGRS QTPPGMATPP
1060 1070 1080 1090 1100
IPKITIQIPK GTMSVGKPSS HSQYSSSGSS SSSSSKSHHG HSSLSSSASG
1110 1120 1130 1140 1150
KIKSNKSDGS SGMKIGSSGG GMYSGQSGQS NSQSKNSSQS MGKAGSSPIT
1160 1170 1180 1190 1200
KHGLSSNVNN SSGSKTKPQG KPSVLMNPSL SKPNISPSHS RPSGGSDKLS
1210 1220 1230 1240 1250
SPMKPMPGTP PSSKAKSPIG SGGQHLSGSG SNSTTKSSSG LVSSGSLTQK
1260 1270 1280 1290 1300
PNSSSSSSSS SSSSSSSSSS SSSSFSSGVS QNLHSSSKGK SPSRNKKPSL
1310 1320 1330 1340 1350
TAVIDKLKHG VGTGGPGSED PMDGGVGGGS TGAPSHGMSS KHGLGVGEFP
1360 1370 1380 1390 1400
TKREKGEKDK SKGSSGGPSD PSKKGGGDSK GSVSTGVAKI IISKHDGGSP
1410 1420 1430 1440 1450
SIKAKVTLQK PEGGGEGLRS QMQKNYGSPL ISGSTPKHER CSPSHNKSPA
1460 1470 1480 1490 1500
YTPQALDSES ESGSSSIAEK SYQNSPSSDD GGGSGSRAQT EYSAEKHKKH
1510 1520 1530 1540 1550
KKEKKRLKDK DRDREKKKSY TMKPESWSKS PISADPTMAM GGGAMMSSDR
1560 1570
ASRPTPSFLM GDDDDLIDVP LTL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC127309 mRNA Translation: AAI27310.1 |
RefSeqi | NP_001090727.1, NM_001097258.1 |
Genome annotation databases
GeneIDi | 100036710 |
KEGGi | xtr:100036710 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC127309 mRNA Translation: AAI27310.1 |
RefSeqi | NP_001090727.1, NM_001097258.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ZMH | X-ray | 2.10 | C | 624-636 | [»] | |
2ZMI | X-ray | 1.70 | C | 624-636 | [»] | |
2ZMJ | X-ray | 2.35 | C | 624-636 | [»] | |
2ZXM | X-ray | 3.01 | C | 624-636 | [»] | |
2ZXN | X-ray | 2.10 | C | 624-636 | [»] | |
3AFR | X-ray | 2.00 | C | 624-636 | [»] | |
AlphaFoldDBi | A1L0Z0 | |||||
SMRi | A1L0Z0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000051133 |
Proteomic databases
PaxDbi | A1L0Z0 |
Genome annotation databases
GeneIDi | 100036710 |
KEGGi | xtr:100036710 |
Organism-specific databases
CTDi | 5469 |
Phylogenomic databases
eggNOGi | ENOG502QPZ7, Eukaryota |
InParanoidi | A1L0Z0 |
OrthoDBi | 57581at2759 |
Miscellaneous databases
EvolutionaryTracei | A1L0Z0 |
Family and domain databases
IDEALi | IID50031 |
InterProi | View protein in InterPro IPR019680, Mediator_Med1 |
Pfami | View protein in Pfam PF10744, Med1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MED1_XENTR | |
Accessioni | A1L0Z0Primary (citable) accession number: A1L0Z0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | May 25, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families