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Entry version 63 (02 Jun 2021)
Sequence version 1 (06 Feb 2007)
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Protein

Neuralized-like protein 4

Gene

neurl4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuralized-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:neurl4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5825550, neurl4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002991071 – 1477Neuralized-like protein 4Add BLAST1477

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. This ubiquitination leads to proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L0Y2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000038676

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1L0Y2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 167NHR 1PROSITE-ProRule annotationAdd BLAST167
Domaini250 – 417NHR 2PROSITE-ProRule annotationAdd BLAST168
Domaini450 – 616NHR 3PROSITE-ProRule annotationAdd BLAST167
Domaini645 – 813NHR 4PROSITE-ProRule annotationAdd BLAST169
Domaini841 – 1010NHR 5PROSITE-ProRule annotationAdd BLAST170
Domaini1048 – 1211NHR 6PROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni168 – 196DisorderedSequence analysisAdd BLAST29
Regioni1012 – 1041DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 26Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4625, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L0Y2

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITARECD

Database of Orthologous Groups

More...
OrthoDBi
74097at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12429, PTHR12429, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07177, Neuralized, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00588, NEUZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51065, NHR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A1L0Y2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAELHPRTGK LISLSNGNRT AARKQPAQEF NQGLVVSARP LGPGEVFTVR
60 70 80 90 100
LDRKMNSWSG SMEIGLTTQD PAFLDFPSSA TGLKGGSWIV SGCSVLEDGR
110 120 130 140 150
SVLEEYGQDL DQLGEGDRVG VQRSISGELH LWVNGRDCGA ASCGIPPRVW
160 170 180 190 200
AVVDLYGKCT QITVLSCQPP PEEEEEEDAE EQEGSLVPLG QSRPDKFPNS
210 220 230 240 250
LDTDSGFPST ELSAVVSNAI LSAYHGSLLS VSLGSPPAAI EHSPPTCNDA
260 270 280 290 300
LLFHEKCGTL IKLSNGNKTA ERRRPLDEFN NGVVMTNRPL RDCEMFEIRI
310 320 330 340 350
DKLVDKWSGS IEIGVTTHNP NSLEYPATMT NLRSGTIMMS GCGILTNGKG
360 370 380 390 400
TRREYCEFSL DELQEGDHIG LTRKSSGALH FYINGMDQGV ASCQTPPVVY
410 420 430 440 450
GVVDLYGMAV KVTIVHNHNH ADRLRRNNAI LRARSPDTGR HSSSTPEPGQ
460 470 480 490 500
LLFHSNCGQK ASIINGGRTA LRPHATDDFN HGVVLSNRPL QNNEVFQVRI
510 520 530 540 550
DKMVDKWAGS IEIGVTTHNP AYLQLPSTMT NLRSGTWMMT GNGVMHNGTT
560 570 580 590 600
ILDEYGHNLD RLKAGDTVGV VRREDGTLNF FVNGIAQGVA AWNVPPNVFA
610 620 630 640 650
VVDLYGQAAQ ATIMDESDAL PLPGDEDEGL ALTPGTPCAL LSLSDLRFHH
660 670 680 690 700
LHGANALITN GGRTVLRKNS RSEFNDAIVM SSRPLRDGEM FEIVIQKMVD
710 720 730 740 750
RWSGSIEAGV TAIRPEDLEF PNTMTDIDYD TWMLSGTAIM QDGNTLRNNY
760 770 780 790 800
GCDLDSLGAG SRIGMMKTIR GDLHYFINGE DQGVACTGLP MGRDIYAVID
810 820 830 840 850
LYGQCVQVSL TGGSGLVDNS LSASHVTDKS LPSQSPVPSV SHRFHTVCGK
860 870 880 890 900
NVSVLCDGTR AERGAGCSHG IVFSSRELLT NETFEIRVEK IEPHWSGSCN
910 920 930 940 950
IGVTSLSPHE VSLLGGGLPE RALELRSKVT WLVCGSEVTR NGQRLRENYC
960 970 980 990 1000
NSLERVRVGS RLGVRRDSDD TLHILMNGED MGPAACGIPK AVYAVLDIHG
1010 1020 1030 1040 1050
CITALSTVSS SLLEEPDATK PPSITSESEE EEDPADHGDP HTVIQAHSLQ
1060 1070 1080 1090 1100
FLANHGKNIL LSHGNRTATR VSSYNQGIVV LPQPLPRLFL FQIRIDQLSP
1110 1120 1130 1140 1150
HWTSSLSIGV IAVSPERLNF PATAAALKRS SWIFQRSAVL CNGVKIREGY
1160 1170 1180 1190 1200
GPNLDLCPEG TCLGLLLDSS GGLHLYVNGL DQGVGAQDLP EVCYVLVDLY
1210 1220 1230 1240 1250
GQCEQVSIVT GEAQGAELDA HEGQLPGERE KADMVDGVKE SLCWVPPDPV
1260 1270 1280 1290 1300
ALLSCEYLAL CTRFKDLLLL PDGYFLEDSK LCVCHCDSCH KLRGDETYRK
1310 1320 1330 1340 1350
RGDPPREYAE PIGWCSFPLR LSPRSSCAQY KKWHIAYQGS SAGTIRRTLD
1360 1370 1380 1390 1400
RGDLLPGSAC ILTSVPAKSD PQSGFPAAEP NVLPPRDLQS VVLSPTLRYA
1410 1420 1430 1440 1450
ALPEMCPKVM FRDPRSQRMF GAQVALQVCV RPGSYKTGPP SACAIDLMDP
1460 1470
RIPSSEMEFL TKEKGATVLR GLLVRVE
Length:1,477
Mass (Da):160,373
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23805E3E8E237EC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZXH9F6ZXH9_XENTR
Neuralized-like protein 4
neurl4
1,172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8SS24A0A6I8SS24_XENTR
Neuralized-like protein 4
neurl4
1,422Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8T157A0A6I8T157_XENTR
Neuralized-like protein 4
neurl4
1,423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC127281 mRNA Translation: AAI27282.1

NCBI Reference Sequences

More...
RefSeqi
NP_001090721.1, NM_001097252.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100036703

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100036703

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127281 mRNA Translation: AAI27282.1
RefSeqiNP_001090721.1, NM_001097252.1

3D structure databases

SMRiA1L0Y2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000038676

Proteomic databases

PaxDbiA1L0Y2

Genome annotation databases

GeneIDi100036703
KEGGixtr:100036703

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84461
XenbaseiXB-GENE-5825550, neurl4

Phylogenomic databases

eggNOGiKOG4625, Eukaryota
InParanoidiA1L0Y2
OMAiITARECD
OrthoDBi74097at2759

Family and domain databases

Gene3Di2.60.120.920, 6 hits
InterProiView protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR037962, Neuralized
IPR006573, NHR_dom
PANTHERiPTHR12429, PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177, Neuralized, 6 hits
SMARTiView protein in SMART
SM00588, NEUZ, 6 hits
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51065, NHR, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUL4_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L0Y2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 6, 2007
Last modified: June 2, 2021
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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