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Entry version 82 (12 Aug 2020)
Sequence version 2 (15 May 2007)
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Protein
Submitted name:

TNS1 protein

Gene

TNS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A1L0S7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TNS1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junctionARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36660

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A1L0S7

PRoteomics IDEntifications database

More...
PRIDEi
A1L0S7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1L0S7, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 230Phosphatase tensin-typeInterPro annotationAdd BLAST173
Domaini235 – 361C2 tensin-typeInterPro annotationAdd BLAST127
Domaini1496 – 1605SH2InterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni431 – 492DisorderedSequence analysisAdd BLAST62
Regioni618 – 637DisorderedSequence analysisAdd BLAST20
Regioni645 – 761DisorderedSequence analysisAdd BLAST117
Regioni779 – 1434DisorderedSequence analysisAdd BLAST656

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 49PolarSequence analysisAdd BLAST21
Compositional biasi432 – 487PolarSequence analysisAdd BLAST56
Compositional biasi661 – 680PolarSequence analysisAdd BLAST20
Compositional biasi696 – 718PolarSequence analysisAdd BLAST23
Compositional biasi792 – 823PolarSequence analysisAdd BLAST32
Compositional biasi863 – 878PolarSequence analysisAdd BLAST16
Compositional biasi879 – 893Pro-richSequence analysisAdd BLAST15
Compositional biasi954 – 973PolarSequence analysisAdd BLAST20
Compositional biasi1100 – 1200PolarSequence analysisAdd BLAST101
Compositional biasi1213 – 1249PolarSequence analysisAdd BLAST37
Compositional biasi1258 – 1276PolarSequence analysisAdd BLAST19
Compositional biasi1365 – 1386PolarSequence analysisAdd BLAST22
Compositional biasi1395 – 1411PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PTEN phosphatase protein family.ARBA annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K18080

Database of Orthologous Groups

More...
OrthoDBi
172407at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01213, PTB_tensin, 1 hit
cd09927, SH2_Tensin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR013625, PTB
IPR006020, PTB/PI_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR035012, Tensin-like_SH2
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR033929, Tensin_PTB
IPR003595, Tyr_Pase_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08416, PTB, 1 hit
PF10409, PTEN_C2, 1 hit
PF00017, SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462, PTB, 1 hit
SM01326, PTEN_C2, 1 hit
SM00404, PTPc_motif, 1 hit
SM00252, SH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182, C2_TENSIN, 1 hit
PS51181, PPASE_TENSIN, 1 hit
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A1L0S7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NHELVPITTE NAPKNVVDKG EGASRGGNTR KSLEDNGSTR VTPSVQPHLQ
60 70 80 90 100
PIRNMSVSRT MEDSCELDLV YVTERIIAVS FPSTANEENF RSNLREVAQM
110 120 130 140 150
LKSKHGGNYL LFNLSERRPD ITKLHAKVLE FGWPDLHTPA LEKICSICKA
160 170 180 190 200
MDTWLNADPH NVVVLHNKGN RGRIGVVIAA YMHYSNISAS ADQALDRFAM
210 220 230 240 250
KRFYEDKIVP IGQPSQRRYV HYFSGLLSGS IKMNNKPLFL HHVIMHGIPN
260 270 280 290 300
FESKGGCRPF LRIYQAMQPV YTSGIYNIPG DSQTSVCITI EPGLLLKGDI
310 320 330 340 350
LLKCYHKKFR SPARDVIFRV QFHTCAIHDL GVVFGKEDLD DAFKDDRFPE
360 370 380 390 400
YGKVEFVFSY GPEKIQGMEH LENGPSVSVD YNTSDPLIRW DSYDNFSGHR
410 420 430 440 450
DDGMEEVVGH TQGPLDGSLY AKVKKKDSLH GSTGAVNATR PTLSATPNHV
460 470 480 490 500
EHTLSVSSDS GNSTASTKTD KTDEPVPGAS SATAALSPQE KRELDRLLSG
510 520 530 540 550
FGLEREKQGA MYHTQHLRSR PAGGSAVPSS GRHVVPAQVH VNGGALASER
560 570 580 590 600
ETDILDDELP NQDGHSAGSM GTLSSLDGVT NISEGGYPEA LSPLTNGLDK
610 620 630 640 650
SYPMEPMVNG GGYPYESASR AGPAHAGHTA PMRPSYSAQE GLAGYQREGP
660 670 680 690 700
HPAWPQPVTT SHYAHDPSGM FRSQSFSEAE PQLPPAPVRG GSSREAVQRG
710 720 730 740 750
LNSWQQQQQQ QQQPRPPPRQ QERAHLESLV ASRPSPQPLA ETPIPSLPEF
760 770 780 790 800
PRAASQQEIE QSIETLNMLM LDLEPASAAA PLHKSQSVPG AWPGASPLSS
810 820 830 840 850
QPLSGSSRQS HPLTQSRSGY IPSGHSLGTP EPAPRASLES VPPGRSYSPY
860 870 880 890 900
DYQPCLAGPN QDFHSKSPAS SSLPAFLPTT HSPPGPQQPP ASLPGLTAQP
910 920 930 940 950
LLSPKEATSD PSRTPEEEPL NLEGLVAHRV AGVQAREKQP AEPPAPLRRR
960 970 980 990 1000
AASDGQYENQ SPEATSPRSP GVRSPVQCVS PELALTIALN PGGRPKEPHL
1010 1020 1030 1040 1050
HSYKEAFEEM EGTSPSSPPP SGVRSPPGLA KTPLSALGLK PHNPADILLH
1060 1070 1080 1090 1100
PTGEPRSYVE SVARTAVAGP RAQDSEPKSF SAPATQAYGH EIPLRNGTLG
1110 1120 1130 1140 1150
GSFVSPSPLS TSSPILSADS TSVGSFPSGE SSDQGPRTPT QPLLESGFRS
1160 1170 1180 1190 1200
GSLGQPSPSA QRNYQSSSPL PTVGSSYSSP DYSLQHFSSS PESQARAQFS
1210 1220 1230 1240 1250
VAGVHTVPGS PQARHRTVGT NTPPSPGFGR RAINSSMAAP SSPSLSHHQM
1260 1270 1280 1290 1300
MGPPGTGFHG STVSSPQSSA ATTPGSPSLC RHPAGVYQVS GLHNKVATTP
1310 1320 1330 1340 1350
GSPSLGRHPG AHQGNLASGL HSNAIASPGS PSLGRHLGGS GSVVPGSPCL
1360 1370 1380 1390 1400
DRHVAYGGYS TPEDRRPTLS RQSSASGYQA PSTPSFPVSP AYYPGLSSPA
1410 1420 1430 1440 1450
TSPSPDSAAF RQGSPTPALP EKRRMSVGDR AGSLPNYATI NGKVSSPVAS
1460 1470 1480 1490 1500
GMSSPSGGST VSFSHTLPDF SKYSMPDNSP ETRAKVKFVQ DTSKYWYKPE
1510 1520 1530 1540 1550
ISREQAIALL KDQEPGAFII RDSHSFRGAY GLAMKVSSPP PTIMQQNKKG
1560 1570 1580 1590 1600
DMTHELVRHF LIETGPRGVK LKGCPNEPNF GSLSALVYQH SIIPLALPCK
1610 1620 1630 1640 1650
LVIPNRDPTD ESKDSSGPTN STADLLKQGA ACNVLFINSV DMESLTGPQA
1660 1670 1680 1690 1700
ISKATSETLA ADPTPAATIV HFKVSAQGIT LTDNQRKLFF RRHYPLNTVT
1710 1720 1730 1740 1750
FCDLDPQERK WMKTEGGAPA KLFGFVARKQ GSTTDNACHL FAELDPNQPA
1760
SAIVNFVSKV MLNAGQKR
Length:1,768
Mass (Da):189,039
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56822A7AD0C0821C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC126910 mRNA Translation: AAI26911.2

NCBI Reference Sequences

More...
RefSeqi
NP_072174.3, NM_022648.5

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7145

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7145

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126910 mRNA Translation: AAI26911.2
RefSeqiNP_072174.3, NM_022648.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA1L0S7
PRIDEiA1L0S7

Genome annotation databases

GeneIDi7145
KEGGihsa:7145

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7145
PharmGKBiPA36660

Phylogenomic databases

KOiK18080
OrthoDBi172407at2759

Enzyme and pathway databases

SignaLinkiA1L0S7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7145, 2 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNS1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7145

Gene expression databases

GenevisibleiA1L0S7, HS

Family and domain databases

CDDicd01213, PTB_tensin, 1 hit
cd09927, SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR013625, PTB
IPR006020, PTB/PI_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR035012, Tensin-like_SH2
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR033929, Tensin_PTB
IPR003595, Tyr_Pase_cat
PfamiView protein in Pfam
PF08416, PTB, 1 hit
PF10409, PTEN_C2, 1 hit
PF00017, SH2, 1 hit
SMARTiView protein in SMART
SM00462, PTB, 1 hit
SM01326, PTEN_C2, 1 hit
SM00404, PTPc_motif, 1 hit
SM00252, SH2, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182, C2_TENSIN, 1 hit
PS51181, PPASE_TENSIN, 1 hit
PS50001, SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1L0S7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L0S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: May 15, 2007
Last modified: August 12, 2020
This is version 82 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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