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Protein

Peroxidasin-like protein

Gene

PXDNL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei812Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi813CalciumPROSITE-ProRule annotation1
Metal bindingi891CalciumPROSITE-ProRule annotation1
Metal bindingi893Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi895CalciumPROSITE-ProRule annotation1
Metal bindingi897CalciumPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei960Transition state stabilizerPROSITE-ProRule annotation1
Metal bindingi1057Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, Oxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.11.1.7 2681

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
5398 HsPxd02
5827 HsPxd03

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxidasin-like protein (EC:1.11.1.7)
Alternative name(s):
Cardiac peroxidase
Vascular peroxidase 2
polysomal ribonuclease 1
Short name:
PRM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PXDNL
Synonyms:VPO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147485.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26359 PXDNL

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1KZ92

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
137902

Open Targets

More...
OpenTargetsi
ENSG00000147485

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671110

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PXDNL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033073124 – 1463Peroxidasin-like proteinAdd BLAST1440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi255 ↔ 305By similarity
Disulfide bondi351 ↔ 398By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi440 ↔ 488By similarity
Disulfide bondi532 ↔ 580By similarity
Disulfide bondi718 ↔ 734By similarity
Disulfide bondi832 ↔ 842By similarity
Disulfide bondi836 ↔ 859By similarity
Disulfide bondi944 ↔ 953By similarity
Disulfide bondi1160 ↔ 1217By similarity
Disulfide bondi1258 ↔ 1284By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by SRC on tyrosine residues is required for targeting to polysomes.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A1KZ92

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1KZ92

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1KZ92

PRoteomics IDEntifications database

More...
PRIDEi
A1KZ92

ProteomicsDB human proteome resource

More...
ProteomicsDBi
126
127 [A1KZ92-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1KZ92

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1KZ92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147485 Expressed in 75 organ(s), highest expression level in right atrium auricular region

CleanEx database of gene expression profiles

More...
CleanExi
HS_PXDNL

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A1KZ92 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A1KZ92 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007919

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126492, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348645

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A1KZ92

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1KZ92

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 50LRRNTAdd BLAST27
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 72LRR 1Add BLAST22
Repeati75 – 96LRR 2Add BLAST22
Repeati99 – 120LRR 3Add BLAST22
Repeati123 – 144LRR 4Add BLAST22
Repeati147 – 168LRR 5Add BLAST22
Domaini180 – 233LRRCTAdd BLAST54
Domaini234 – 322Ig-like C2-type 1Add BLAST89
Domaini330 – 414Ig-like C2-type 2Add BLAST85
Domaini419 – 504Ig-like C2-type 3Add BLAST86
Domaini507 – 596Ig-like C2-type 4Add BLAST90
Domaini1393 – 1451VWFCPROSITE-ProRule annotationAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2408 Eukaryota
ENOG410XPZ3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163562

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016084

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108312

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1KZ92

KEGG Orthology (KO)

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KOi
K19511

Identification of Orthologs from Complete Genome Data

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OMAi
RVRNGRC

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0236

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1KZ92

TreeFam database of animal gene trees

More...
TreeFami
TF314316

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09826 peroxidasin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR034824 Peroxidasin_peroxidase
IPR029610 PXDNL
IPR001007 VWF_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11475:SF38 PTHR11475:SF38, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098 An_peroxidase, 1 hit
PF07679 I-set, 3 hits
PF13855 LRR_8, 2 hits
PF00093 VWC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457 ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00214 VWC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48113 SSF48113, 1 hit
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS51450 LRR, 6 hits
PS50292 PEROXIDASE_3, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A1KZ92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRLFCWTT LFLLAGWCLP GLPCPSRCLC FKSTVRCMHL MLDHIPQVPQ
60 70 80 90 100
QTTVLDLRFN RIREIPGSAF KKLKNLNTLL LNNNHIRKIS RNAFEGLENL
110 120 130 140 150
LYLYLYKNEI HALDKQTFKG LISLEHLYIH FNQLEMLQPE TFGDLLRLER
160 170 180 190 200
LFLHNNKLSK IPAGSFSNLD SLKRLRLDSN ALVCDCDLMW LGELLQGFAQ
210 220 230 240 250
HGHTQAAATC EYPRRLHGRA VASVTVEEFN CQSPRITFEP QDVEVPSGNT
260 270 280 290 300
VYFTCRAEGN PKPEIIWIHN NHSLDLEDDT RLNVFDDGTL MIRNTRESDQ
310 320 330 340 350
GVYQCMARNS AGEAKTQSAM LRYSSLPAKP SFVIQPQDTE VLIGTSTTLE
360 370 380 390 400
CMATGHPHPL ITWTRDNGLE LDGSRHVATS SGLYLQNITQ RDHGRFTCHA
410 420 430 440 450
NNSHGTVQAA ANIIVQAPPQ FTVTPKDQVV LEEHAVEWLC EADGNPPPVI
460 470 480 490 500
VWTKTGGQLP VEGQHTVLSS GTLRIDRAAQ HDQGQYECQA VSSLGVKKVS
510 520 530 540 550
VQLTVKPKAL AVFTQLPQDT SVEVGKNINI SCHAQGEPQP IITWNKEGVQ
560 570 580 590 600
ITESGKFHVD DEGTLTIYDA GFPDQGRYEC VARNSFGLAV TNMFLTVTAI
610 620 630 640 650
QGRQAGDDFV ESSILDAVQR VDSAINSTRR HLFSQKPHTS SDLLAQFHYP
660 670 680 690 700
RDPLIVEMAR AGEIFEHTLQ LIRERVKQGL TVDLEGKEFR YNDLVSPRSL
710 720 730 740 750
SLIANLSGCT ARRPLPNCSN RCFHAKYRAH DGTCNNLQQP TWGAALTAFA
760 770 780 790 800
RLLQPAYRDG IRAPRGLGLP VGSRQPLPPP RLVATVWARA AAVTPDHSYT
810 820 830 840 850
RMLMHWGWFL EHDLDHTVPA LSTARFSDGR PCSSVCTNDP PCFPMNTRHA
860 870 880 890 900
DPRGTHAPCM LFARSSPACA SGRPSATVDS VYAREQINQQ TAYIDGSNVY
910 920 930 940 950
GSSERESQAL RDPSVPRGLL KTGFPWPPSG KPLLPFSTGP PTECARQEQE
960 970 980 990 1000
SPCFLAGDHR ANEHLALAAM HTLWFREHNR MATELSALNP HWEGNTVYQE
1010 1020 1030 1040 1050
ARKIVGAELQ HITYSHWLPK VLGDPGTRML RGYRGYNPNV NAGIINSFAT
1060 1070 1080 1090 1100
AAFRFGHTLI NPILYRLNAT LGEISEGHLP FHKALFSPSR IIKEGGIDPV
1110 1120 1130 1140 1150
LRGLFGVAAK WRAPSYLLSP ELTQRLFSAA YSAAVDSAAT IIQRGRDHGI
1160 1170 1180 1190 1200
PPYVDFRVFC NLTSVKNFED LQNEIKDSEI RQKLRKLYGS PGDIDLWPAL
1210 1220 1230 1240 1250
MVEDLIPGTR VGPTLMCLFV TQFQRLRDGD RFWYENPGVF TPAQLTQLKQ
1260 1270 1280 1290 1300
ASLSRVLCDN GDSIQQVQAD VFVKAEYPQD YLNCSEIPKV DLRVWQDCCA
1310 1320 1330 1340 1350
DCRSRGQFRA VTQESQKKRS AQYSYPVDKD MELSHLRSRQ QDKIYVGEDA
1360 1370 1380 1390 1400
RNVTVLAKTK FSQDFSTFAA EIQETITALR EQINKLEARL RQAGCTDVRG
1410 1420 1430 1440 1450
VPRKAEERWM KEDCTHCICE SGQVTCVVEI CPPAPCPSPE LVKGTCCPVC
1460
RDRGMPSDSP EKR
Length:1,463
Mass (Da):163,686
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6FE8200892CCCAE
GO
Isoform 2 (identifier: A1KZ92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1302-1316: CRSRGQFRAVTQESQ → KQAGGTPEAGRVYRC
     1317-1463: Missing.

Note: No experimental confirmation available.
Show »
Length:1,316
Mass (Da):146,935
Checksum:iB9FD640C9FF6E1FF
GO
Isoform PMR1 (identifier: A1KZ92-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-801: Missing.
     1302-1463: CRSRGQFRAV...GMPSDSPEKR → KQAGGTPEAGRVYRC

Show »
Length:515
Mass (Da):57,461
Checksum:i5A872CB698D94326
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAV0H0YAV0_HUMAN
Peroxidasin-like protein
PXDNL
537Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K4DIA6K4DIA6_HUMAN
Peroxidasin-like protein
PXDNL
582Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAX70929 differs from that shown. Reason: Frameshift at positions 127 and 132.Curated
The sequence BAB71713 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD18663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW86707 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti781R → G in BAD18663 (PubMed:14702039).Curated1
Sequence conflicti833S → N in BAD18663 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050488343I → T. Corresponds to variant dbSNP:rs7833909Ensembl.1
Natural variantiVAR_050489583R → Q. Corresponds to variant dbSNP:rs16916235Ensembl.1
Natural variantiVAR_050490616D → A. Corresponds to variant dbSNP:rs16916207Ensembl.1
Natural variantiVAR_050491981M → V4 PublicationsCorresponds to variant dbSNP:rs2977020Ensembl.1
Natural variantiVAR_0504921327V → D. Corresponds to variant dbSNP:rs11774588Ensembl.1
Natural variantiVAR_0504931399R → K1 PublicationCorresponds to variant dbSNP:rs7827446Ensembl.1
Natural variantiVAR_0504941452D → E1 PublicationCorresponds to variant dbSNP:rs1052704Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0442401 – 801Missing in isoform PMR1. CuratedAdd BLAST801
Alternative sequenceiVSP_0442411302 – 1463CRSRG…SPEKR → KQAGGTPEAGRVYRC in isoform PMR1. CuratedAdd BLAST162
Alternative sequenceiVSP_0330701302 – 1316CRSRG…TQESQ → KQAGGTPEAGRVYRC in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0330711317 – 1463Missing in isoform 2. 1 PublicationAdd BLAST147

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU170240 mRNA Translation: ABX24517.1
AY877349 mRNA Translation: AAX70929.1 Frameshift.
AC090186 Genomic DNA No translation available.
AC103958 Genomic DNA No translation available.
AC107374 Genomic DNA No translation available.
AC011128 Genomic DNA No translation available.
AC012413 Genomic DNA No translation available.
AK058200 mRNA Translation: BAB71713.1 Different initiation.
AK131524 mRNA Translation: BAD18663.1 Different initiation.
CH471068 Genomic DNA Translation: EAW86707.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47855.1 [A1KZ92-1]

NCBI Reference Sequences

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RefSeqi
NP_653252.3, NM_144651.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.444882

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000356297; ENSP00000348645; ENSG00000147485 [A1KZ92-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
137902

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:137902

UCSC genome browser

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UCSCi
uc003xqu.5 human [A1KZ92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU170240 mRNA Translation: ABX24517.1
AY877349 mRNA Translation: AAX70929.1 Frameshift.
AC090186 Genomic DNA No translation available.
AC103958 Genomic DNA No translation available.
AC107374 Genomic DNA No translation available.
AC011128 Genomic DNA No translation available.
AC012413 Genomic DNA No translation available.
AK058200 mRNA Translation: BAB71713.1 Different initiation.
AK131524 mRNA Translation: BAD18663.1 Different initiation.
CH471068 Genomic DNA Translation: EAW86707.1 Sequence problems.
CCDSiCCDS47855.1 [A1KZ92-1]
RefSeqiNP_653252.3, NM_144651.4
UniGeneiHs.444882

3D structure databases

ProteinModelPortaliA1KZ92
SMRiA1KZ92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126492, 7 interactors
STRINGi9606.ENSP00000348645

Protein family/group databases

PeroxiBasei5398 HsPxd02
5827 HsPxd03

PTM databases

iPTMnetiA1KZ92
PhosphoSitePlusiA1KZ92

Polymorphism and mutation databases

BioMutaiPXDNL

Proteomic databases

EPDiA1KZ92
MaxQBiA1KZ92
PaxDbiA1KZ92
PRIDEiA1KZ92
ProteomicsDBi126
127 [A1KZ92-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356297; ENSP00000348645; ENSG00000147485 [A1KZ92-1]
GeneIDi137902
KEGGihsa:137902
UCSCiuc003xqu.5 human [A1KZ92-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
137902
DisGeNETi137902
EuPathDBiHostDB:ENSG00000147485.12

GeneCards: human genes, protein and diseases

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GeneCardsi
PXDNL
HGNCiHGNC:26359 PXDNL
HPAiHPA007919
neXtProtiNX_A1KZ92
OpenTargetsiENSG00000147485
PharmGKBiPA142671110

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00940000163562
HOGENOMiHOG000016084
HOVERGENiHBG108312
InParanoidiA1KZ92
KOiK19511
OMAiRVRNGRC
OrthoDBiEOG091G0236
PhylomeDBiA1KZ92
TreeFamiTF314316

Enzyme and pathway databases

BRENDAi1.11.1.7 2681

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
137902

Protein Ontology

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PROi
PR:A1KZ92

Gene expression databases

BgeeiENSG00000147485 Expressed in 75 organ(s), highest expression level in right atrium auricular region
CleanExiHS_PXDNL
ExpressionAtlasiA1KZ92 baseline and differential
GenevisibleiA1KZ92 HS

Family and domain databases

CDDicd09826 peroxidasin_like, 1 hit
Gene3Di1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR034824 Peroxidasin_peroxidase
IPR029610 PXDNL
IPR001007 VWF_dom
PANTHERiPTHR11475:SF38 PTHR11475:SF38, 3 hits
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF07679 I-set, 3 hits
PF13855 LRR_8, 2 hits
PF00093 VWC, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF48113 SSF48113, 1 hit
SSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS51450 LRR, 6 hits
PS50292 PEROXIDASE_3, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDNL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1KZ92
Secondary accession number(s): B5ME43
, B6CGZ3, H0YBM9, Q6ZMR2, Q96LH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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