Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine protease

Gene
N/A
Organism
Blomia tropicalis (Mite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cysteine protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137By similarity1
Active sitei281By similarity1
Active sitei301By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteaseCurated (EC:3.4.22.-Curated)
Alternative name(s):
Allergen: Blo t 11 Publication
OrganismiBlomia tropicalis (Mite)Imported
Taxonomic identifieri40697 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataGlycyphagoideaEchimyopodidaeBlomia

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei146 Blo t 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000044442719 – 108Activation peptide1 PublicationAdd BLAST90
ChainiPRO_0000444428109 – 333Cysteine protease1 PublicationAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparaginePROSITE-ProRule annotationCombined sources1 Publication1
Disulfide bondi134 ↔ 182Combined sources1 Publication
Disulfide bondi168 ↔ 214Combined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliA1KXI0
SMRiA1KXI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1KXI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLLVAALC ALVAIGSCKP TREEIKTFEQ FKKVFGKVYR NAEEEARREH
60 70 80 90 100
HFKEQLKWVE EHNGIDGVEY AINEYSDMSE QEFSFHLSGG GLNFTYMKME
110 120 130 140 150
AAKEPLINTY GSLPQNFDWR QKARLTRIRQ QGSCGSCWAF AAAGVAESLY
160 170 180 190 200
SIQKQQSIEL SEQELVDCTY NRYDSSYQCN GCGSGYSTEA FKYMIRTGLV
210 220 230 240 250
EEENYPYNMR TQWCNPDVEG QRYHVSGYQQ LRYQSSDEDV MYTIQQHGPV
260 270 280 290 300
VIYMHGSNNY FRNLGNGVLR GVAYNDAYTD HAVILVGWGT VQGVDYWIIR
310 320 330
NSWGTGWGNG GYGYVERGHN SLGINNFVTY ATL
Length:333
Mass (Da):38,102
Last modified:February 6, 2007 - v1
Checksum:i8C62C882C0CB4AC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133S → A no nucleotide entry (PubMed:12911421).Curated1
Sequence conflicti159E → G no nucleotide entry (PubMed:12911421).Curated1
Sequence conflicti175S → P no nucleotide entry (PubMed:12911421).Curated1
Sequence conflicti203E → R no nucleotide entry (PubMed:12911421).Curated1
Sequence conflicti215N → D no nucleotide entry (PubMed:12911421).Curated1
Sequence conflicti234Q → H no nucleotide entry (PubMed:12911421).Curated1
Sequence conflicti327F → Y no nucleotide entry (PubMed:12911421).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY291322 mRNA Translation: AAQ24541.1

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY291322 mRNA Translation: AAQ24541.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JT8X-ray2.10A/B24-333[»]
ProteinModelPortaliA1KXI0
SMRiA1KXI0
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei146 Blo t 1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYSP_BLOTA
AccessioniPrimary (citable) accession number: A1KXI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: February 6, 2007
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again