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Protein

Fas apoptotic inhibitory molecule 3

Gene

Fcmr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3By similarity
Alternative name(s):
IgM Fc fragment receptorBy similarityImported
Regulator of Fas-induced apoptosis TosoBy similarity
Gene namesi
Name:FcmrBy similarityImported
Synonyms:Faim3, Toso
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916419 Fcmr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 262ExtracellularSequence analysisAdd BLAST245
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 422CytoplasmicSequence analysisAdd BLAST139

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028442218 – 422Fas apoptotic inhibitory molecule 3Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 103By similarity
Modified residuei91PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiA1KXC4
PRIDEiA1KXC4

PTM databases

iPTMnetiA1KXC4
PhosphoSitePlusiA1KXC4

Expressioni

Gene expression databases

CleanExiMM_FAIM3

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048303

Structurei

3D structure databases

ProteinModelPortaliA1KXC4
SMRiA1KXC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 104Ig-likeAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 339Arg-richAdd BLAST55

Domaini

The Ig-like domain is required for the anti-apoptotic ability.By similarity

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J Eukaryota
ENOG41113GQ LUCA
HOGENOMiHOG000013142
HOVERGENiHBG107910
InParanoidiA1KXC4
PhylomeDBiA1KXC4
TreeFamiTF338713

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1KXC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFWLWLLYF LPVSGALRVL PEVQLNVEWG GSIIIECPLP QLHVRMYLCR
60 70 80 90 100
QMAKPGICST VVSNTFVKKE YERRVTLTPC LDKKLFLVEM TQLTENDDGI
110 120 130 140 150
YACGVGMKTD KGKTQKITLN VHNEYPEPFW EDEWTSERPR WLHRFLQHQM
160 170 180 190 200
PWLHGSEHPS SSGVIAKVTT PAPKTEAPPV HQPSSITSVT QHPRVYRAFS
210 220 230 240 250
VSATKSPALL PATTASKTST QQAIRPLEAS YSHHTRLHEQ RTRHHGPHYG
260 270 280 290 300
REDRGLHIPI PEFHILIPTF LGFLLLVLLG LVVKRAIQRR RASSRRAGRL
310 320 330 340 350
AMRRRGRGAS RPFPTQRRDA SQRPRSQNNV YSACPRRARG PDSLGPAEAP
360 370 380 390 400
LLNAPASASP ASPQVLEAPW PHTPSLKMSC EYVSLGYQPA VNLEDPDSDD
410 420
YINIPDPSHL PSYAPGPRSS CP
Length:422
Mass (Da):47,471
Last modified:April 17, 2007 - v2
Checksum:i24270D3B50AD871E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2LB91A0A0G2LB91_MOUSE
Fas apoptotic inhibitory molecule 3
Fcmr
422Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172A → T in AAP51725 (Ref. 1) Curated1
Sequence conflicti172A → T in AAP51727 (Ref. 1) Curated1
Sequence conflicti172A → T in AAP51728 (Ref. 1) Curated1
Sequence conflicti172A → T in AAP51729 (Ref. 1) Curated1
Sequence conflicti172A → T in BAE33514 (PubMed:16141072).Curated1
Sequence conflicti172A → T in BAB25207 (PubMed:16141072).Curated1
Sequence conflicti179P → L in AAP51728 (Ref. 1) Curated1
Sequence conflicti217K → R in AAP51728 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51723 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51724 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51725 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51726 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51730 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51731 (Ref. 1) Curated1
Sequence conflicti321S → P in AAI16675 (PubMed:15489334).Curated1
Sequence conflicti321S → P in AAI18506 (PubMed:15489334).Curated1
Sequence conflicti422P → Q in BAE33514 (PubMed:16141072).Curated1
Sequence conflicti422P → Q in BAB25207 (PubMed:16141072).Curated1
Sequence conflicti422P → Q in AAI16675 (PubMed:15489334).Curated1
Sequence conflicti422P → Q in AAI18506 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227385 mRNA Translation: AAP51723.1
AY227386 mRNA Translation: AAP51724.1
AY227387 mRNA Translation: AAP51725.1
AY227388 mRNA Translation: AAP51726.1
AY227389 mRNA Translation: AAP51727.1
AY227390 mRNA Translation: AAP51728.1
AY227391 mRNA Translation: AAP51729.1
AY227392 mRNA Translation: AAP51730.1
AY227393 mRNA Translation: AAP51731.1
AK007714 mRNA Translation: BAB25207.1
AK155943 mRNA Translation: BAE33514.1
BC118505 mRNA Translation: AAI18506.1
BC116674 mRNA Translation: AAI16675.1
RefSeqiNP_081252.1, NM_026976.2
UniGeneiMm.46042

Genome annotation databases

GeneIDi69169
KEGGimmu:69169
UCSCiuc007cmn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227385 mRNA Translation: AAP51723.1
AY227386 mRNA Translation: AAP51724.1
AY227387 mRNA Translation: AAP51725.1
AY227388 mRNA Translation: AAP51726.1
AY227389 mRNA Translation: AAP51727.1
AY227390 mRNA Translation: AAP51728.1
AY227391 mRNA Translation: AAP51729.1
AY227392 mRNA Translation: AAP51730.1
AY227393 mRNA Translation: AAP51731.1
AK007714 mRNA Translation: BAB25207.1
AK155943 mRNA Translation: BAE33514.1
BC118505 mRNA Translation: AAI18506.1
BC116674 mRNA Translation: AAI16675.1
RefSeqiNP_081252.1, NM_026976.2
UniGeneiMm.46042

3D structure databases

ProteinModelPortaliA1KXC4
SMRiA1KXC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048303

PTM databases

iPTMnetiA1KXC4
PhosphoSitePlusiA1KXC4

Proteomic databases

PaxDbiA1KXC4
PRIDEiA1KXC4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69169
KEGGimmu:69169
UCSCiuc007cmn.1 mouse

Organism-specific databases

CTDi9214
MGIiMGI:1916419 Fcmr

Phylogenomic databases

eggNOGiENOG410IJ2J Eukaryota
ENOG41113GQ LUCA
HOGENOMiHOG000013142
HOVERGENiHBG107910
InParanoidiA1KXC4
PhylomeDBiA1KXC4
TreeFamiTF338713

Miscellaneous databases

PROiPR:A1KXC4
SOURCEiSearch...

Gene expression databases

CleanExiMM_FAIM3

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAIM3_MOUSE
AccessioniPrimary (citable) accession number: A1KXC4
Secondary accession number(s): A1KXC6
, A1KXC8, A1KXC9, Q148B9, Q9D8T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: October 25, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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