UniProtKB - A1KT06 (UBIE_NEIMF)
Protein
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
Gene
ubiE
Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Status
Functioni
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation
Catalytic activityi
- a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.163UniRule annotation
- a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.201UniRule annotation
: menaquinone biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (ubiE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
Pathwayi: ubiquinone biosynthesis
This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 71 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 92 | S-adenosyl-L-methionineUniRule annotation | 1 |
GO - Molecular functioni
- 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Source: UniProtKB-EC
- S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- aerobic respiration Source: UniProtKB-UniRule
- menaquinone biosynthetic process Source: UniProtKB-UniRule
- ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Menaquinone biosynthesis, Ubiquinone biosynthesis |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | NMEN272831:G1G1U-829-MONOMER |
UniPathwayi | UPA00079;UER00169 UPA00232 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)Alternative name(s): 2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation Demethylmenaquinone methyltransferaseUniRule annotation |
Gene namesi | Name:ubiEUniRule annotation Ordered Locus Names:NMC0697 |
Organismi | Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) |
Taxonomic identifieri | 272831 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000056266 | 1 – 245 | Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEAdd BLAST | 245 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 119 | S-adenosyl-L-methionine bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000249463 |
KOi | K03183 |
OMAi | VRNFENL |
OrthoDBi | 1431378at2 |
Family and domain databases
HAMAPi | MF_01813 MenG_UbiE_methyltr, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR004033 UbiE/COQ5_MeTrFase IPR023576 UbiE/COQ5_MeTrFase_CS |
Pfami | View protein in Pfam PF01209 Ubie_methyltran, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
TIGRFAMsi | TIGR01934 MenG_MenH_UbiE, 1 hit |
PROSITEi | View protein in PROSITE PS51608 SAM_MT_UBIE, 1 hit PS01183 UBIE_1, 1 hit PS01184 UBIE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A1KT06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGQKTHFGF STVNEDEKAG KVAEVFHSVA KNYDIMNDVM SAGLHRVWKH
60 70 80 90 100
FTINTAHLKK GDKVLDIAGG TGDLSRGWAK RVGKEGEVWL TDINSSMLTV
110 120 130 140 150
GRDRLLNEGM ILPVSLADAE KLPFPDNYFN LVSVAFGLRN MTHKDAALKE
160 170 180 190 200
MYRVLKPGGT LLVLEFSKIY KPLEGAYDFY SFKLLPVMGK LIAKDADSYQ
210 220 230 240
YLAESIRMHP DQETLKQMML DAGFDSVDYH NMSAGIVALH KGVKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM421808 Genomic DNA Translation: CAM09988.1 |
RefSeqi | WP_002214049.1, NC_008767.1 |
Genome annotation databases
EnsemblBacteriai | CAM09988; CAM09988; NMC0697 |
KEGGi | nmc:NMC0697 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM421808 Genomic DNA Translation: CAM09988.1 |
RefSeqi | WP_002214049.1, NC_008767.1 |
3D structure databases
SMRi | A1KT06 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CAM09988; CAM09988; NMC0697 |
KEGGi | nmc:NMC0697 |
Phylogenomic databases
HOGENOMi | HOG000249463 |
KOi | K03183 |
OMAi | VRNFENL |
OrthoDBi | 1431378at2 |
Enzyme and pathway databases
UniPathwayi | UPA00079;UER00169 UPA00232 |
BioCyci | NMEN272831:G1G1U-829-MONOMER |
Family and domain databases
HAMAPi | MF_01813 MenG_UbiE_methyltr, 1 hit |
InterProi | View protein in InterPro IPR029063 SAM-dependent_MTases IPR004033 UbiE/COQ5_MeTrFase IPR023576 UbiE/COQ5_MeTrFase_CS |
Pfami | View protein in Pfam PF01209 Ubie_methyltran, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
TIGRFAMsi | TIGR01934 MenG_MenH_UbiE, 1 hit |
PROSITEi | View protein in PROSITE PS51608 SAM_MT_UBIE, 1 hit PS01183 UBIE_1, 1 hit PS01184 UBIE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIE_NEIMF | |
Accessioni | A1KT06Primary (citable) accession number: A1KT06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | February 6, 2007 | |
Last modified: | May 8, 2019 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PATHWAY comments
Index of metabolic and biosynthesis pathways