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Protein

Multidrug efflux ATP-binding/permease protein BCG_0231

Gene

BCG_0231

Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Overexpression increases resistance to chloramphenicol, ampicillin, streptomycin, tetracyclin and vancomycin.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi367 – 374ATPPROSITE-ProRule annotation8
Nucleotide bindingi976 – 983ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV410289:G1G1S-250-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug efflux ATP-binding/permease protein BCG_0231Curated (EC:3.6.3.-Curated)
Gene namesi
Ordered Locus Names:BCG_0231Imported
OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
Taxonomic identifieri410289 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001472 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Transmembranei660 – 680HelicalSequence analysisAdd BLAST21
Transmembranei743 – 763HelicalSequence analysisAdd BLAST21
Transmembranei765 – 785HelicalSequence analysisAdd BLAST21
Transmembranei847 – 867HelicalSequence analysisAdd BLAST21
Transmembranei878 – 898HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004328601 – 1194Multidrug efflux ATP-binding/permease protein BCG_0231Add BLAST1194

Structurei

3D structure databases

ProteinModelPortaliA1KF14
SMRiA1KF14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 301ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini334 – 568ABC transporter 1PROSITE-ProRule annotationAdd BLAST235
Domaini628 – 910ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST283
Domaini942 – 1177ABC transporter 2PROSITE-ProRule annotationAdd BLAST236

Domaini

The ATP-binding domains (NBD) and the transmembrane domains (TMD) are fused.Curated

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220302
KOiK18894
OMAiVDCKFTY

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

A1KF14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTNCWWRLS GYVMRHRRDL LLGFGAALAG TVIAVLVPLV TKRVIDDAIA
60 70 80 90 100
ADHRPLAPWA VVLVAAAGAT YLLTYVRRYY GGRIAHLVQH DLRMDAFQAL
110 120 130 140 150
LRWDGRQQDR WSSGQLIVRT TNDLQLVQAL LFDVPNVLRH VLTLLLGVAV
160 170 180 190 200
MTWLSVPLAL LAVLLVPVIG LIAHRSRRLL AAATHCAQEH KAAVTGVVDA
210 220 230 240 250
AVCGIRVVKA FGQEERETVK LVMASRALYA AQLRVARLNA HFGPLLQTLP
260 270 280 290 300
ALGQMAVFAL GGWMAAQGSI TVGTFVAFWA CLTLLARPAC DLAGMLTIAQ
310 320 330 340 350
QARAGAVRVL ELIDSRPTLV DGTKPLSLEA RLSLEFQRVS FGYVADRPVL
360 370 380 390 400
REISLSVRAG ETLAVVGAPG SGKSTLASLA TRCYDVTQGA VRIGGQDVRE
410 420 430 440 450
LTLDSLRSAI GLVPEDAVLF SGTIGANIAY GRPDATPEQI ATAARAAHIE
460 470 480 490 500
EFVNTLPDGY QTAVGARGLT LSGGQRQRIA LARALLHQPR LLIMDDPTSA
510 520 530 540 550
VDAVIECGIQ EVLREAIADR TAVIFTRRRS MLTLADRVAV LDSGRLLDVG
560 570 580 590 600
TPDEVWERCP RYRELLSPAP DLADDLVVAE RSPVCRPVAG LGTKAAQHTN
610 620 630 640 650
VHNPGPHDHP PGPDPLRRLL REFRGPLALS LLLVAVQTCA GLLPPLLIRH
660 670 680 690 700
GIDVGIRRHV LSALWWAALA GTATVVIRWV VQWGSAMVAG YTGEQVLFRL
710 720 730 740 750
RSVVFAHAQR LGLDAFEDDG DAQIVTAVTA DVEAIVAFLR TGLVVAVISV
760 770 780 790 800
VTLVGILVAL LAIRARLVLL IFTTMPVLAL ATWQFRRASN WTYRRARHRL
810 820 830 840 850
GTVTATLREY AAGLRIAQAF RAEYRGLQSY FAHSDDYRRL GVRGQRLLAL
860 870 880 890 900
YYPFVALLCS LATTLVLLDG AREVRAGVIS VGALVTYLLY IELLYTPIGE
910 920 930 940 950
LAQMFDDYQR AAVAAGRIRS LLSTRTPSSP AARPVGTLRG EVVFDAVHYS
960 970 980 990 1000
YRTREVPALA GINLRIPAGQ TVVFVGSTGS GKSTLIKLVA RFYDPTHGTV
1010 1020 1030 1040 1050
RVDGCDLREF DVDGYRNRLG IVTQEQYVFA GTVRDAIAYG RPDATDAQVE
1060 1070 1080 1090 1100
RAAREVGAHP MITALDNGYL HQVTAGGRNL SAGQLQLLAL ARARLVDPDI
1110 1120 1130 1140 1150
LLLDEATVAL DPATEAVVQR ATLTLAARRT TLIVAHGLAI AEHADRIVVL
1160 1170 1180 1190
EHGTVVEDGA HTELLAAGGH YSRLWAAHTR LCSPEITQLQ CIDA
Length:1,194
Mass (Da):129,267
Last modified:February 6, 2007 - v1
Checksum:i5ADF4BA136C2CFB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM408590 Genomic DNA Translation: CAL70215.1
RefSeqiWP_011799083.1, NC_008769.1

Genome annotation databases

EnsemblBacteriaiCAL70215; CAL70215; BCG_0231
KEGGimbb:BCG_0231

Similar proteinsi

Entry informationi

Entry nameiMDREP_MYCBP
AccessioniPrimary (citable) accession number: A1KF14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2015
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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