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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayi
UPA00908;UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:YE0165
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003145021 – 498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseAdd BLAST498

Interactioni

Protein-protein interaction databases

STRINGi393305.YE0165

Structurei

3D structure databases

ProteinModelPortaliA1JI66
SMRiA1JI66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA
OrthoDBiPOG091H00D6

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR022371 Exopolyphosphatase
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit
TIGRFAMsiTIGR03706 exo_poly_only, 1 hit

Sequencei

Sequence statusi: Complete.

A1JI66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLSSTSLYA AIDLGSNSFH MLVVREVAGS IQTLARIKRK VRLAAGLDTQ
60 70 80 90 100
NHLSQEAMER GWQCLKLFSE RLQDIPLDQI RVVATATLRL ASNAEEFLQT
110 120 130 140 150
ATEILGCPIQ VISGEEEARL IYHGVAHTTG GPEQRLVVDI GGGSTELVTG
160 170 180 190 200
NGAQANILVS LPMGCVTWLE RYFSDRNLAK DNFDRSESAA REMLKPVAQR
210 220 230 240 250
FREHGWQICV GASGTVQALQ EIMVAQGMDE LITLAKLQQL KQRAIQCGKL
260 270 280 290 300
EELEIPGLTL ERALVFPSGL SILIAIFQEL AIESMTLAGG ALREGLVYGM
310 320 330 340 350
LHLPVEQDIR SRTVRNIQRR YLLDTEQAKR VSKLADNFLL QVEKEWRLDS
360 370 380 390 400
RCRELLQNAC LIHEIGLSID FKRAPQHAAY LIRNLDLPGF TPAQKLLLAA
410 420 430 440 450
LLQNQSDTLD LSLLNQQNAL PVDMAQHLCR LLRLAIIFSS RRRDDTLPAV
460 470 480 490
RLRANGETLY VLLPHGWLQQ HPYRAEALEQ ESHWQSYVQW PLLLEEFN
Length:498
Mass (Da):55,934
Last modified:February 6, 2007 - v1
Checksum:i70ADAE6AEAC437EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL10304.1
RefSeqiWP_011815326.1, NC_008800.1
YP_001004556.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL10304; CAL10304; YE0165
GeneIDi4714873
KEGGiyen:YE0165
PATRICifig|393305.7.peg.256

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL10304.1
RefSeqiWP_011815326.1, NC_008800.1
YP_001004556.1, NC_008800.1

3D structure databases

ProteinModelPortaliA1JI66
SMRiA1JI66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE0165

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL10304; CAL10304; YE0165
GeneIDi4714873
KEGGiyen:YE0165
PATRICifig|393305.7.peg.256

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA
OrthoDBiPOG091H00D6

Enzyme and pathway databases

UniPathwayi
UPA00908;UER00885

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR022371 Exopolyphosphatase
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit
TIGRFAMsiTIGR03706 exo_poly_only, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPPA_YERE8
AccessioniPrimary (citable) accession number: A1JI66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 10, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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