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Protein

Argininosuccinate lyase

Gene

argH

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:YE0121
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000005521 – 457Argininosuccinate lyaseAdd BLAST457

Proteomic databases

PRIDEiA1JI24

Interactioni

Protein-protein interaction databases

STRINGi393305.YE0121

Structurei

3D structure databases

ProteinModelPortaliA1JI24
SMRiA1JI24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A1JI24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWGGRFSQ AADQRFKQFN DSLRFDYRLA EQDIIGSVAW SKALVTVGVL
60 70 80 90 100
TTAEQQQLEQ ALSVLLEEVQ ADPQAILASD AEDIHSWVET KLIDKVGDLG
110 120 130 140 150
KKLHTGRSRN DQVATDLKLW CKFQITELKT AVQQLQQALV ITAEANQDAV
160 170 180 190 200
MPGYTHLQRA QPVTFAHWCL AYAEMLARDE SRLQDTLKRL DVSPLGSGAL
210 220 230 240 250
AGTAYAIDRE QLAGWLGFAS ATRNSLDSVS DRDHVLELLS DASIGMVHLS
260 270 280 290 300
RFAEDLIFFN SGEAAFVDLS DRVTSGSSLM PQKKNPDALE LIRGKCGRVQ
310 320 330 340 350
GALTGMMMTL KGLPLAYNKD MQEDKEGLFD ALDTWLDCLH MAALVLDGIQ
360 370 380 390 400
VKRPRCKEAA EQGYANATEL ADYLVAKGVP FREAHHIVGE AVVEAIRQGK
410 420 430 440 450
ALEALSLSDL QKFSAVIGDD VYPILALQSC LDKRVAKGGV SPQQVASAIA

EAKARLF
Length:457
Mass (Da):50,017
Last modified:February 6, 2007 - v1
Checksum:iFAD38880C9498AA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL10262.1
RefSeqiWP_011815303.1, NC_008800.1
YP_001004514.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL10262; CAL10262; YE0121
GeneIDi4715031
KEGGiyen:YE0121
PATRICifig|393305.7.peg.212

Similar proteinsi

Entry informationi

Entry nameiARLY_YERE8
AccessioniPrimary (citable) accession number: A1JI24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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