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Entry version 90 (16 Jan 2019)
Sequence version 2 (20 May 2008)
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Protein

Rho guanine nucleotide exchange factor 37

Gene

ARHGEF37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183111.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34430 ARHGEF37

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1IGU5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000183111

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165660135

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF37

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370501 – 675Rho guanine nucleotide exchange factor 37Add BLAST675

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A1IGU5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A1IGU5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1IGU5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1IGU5

PRoteomics IDEntifications database

More...
PRIDEi
A1IGU5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
123

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1IGU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1IGU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183111 Expressed in 203 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1IGU5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1IGU5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043885
HPA053487

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
133100, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328083

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A1IGU5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1IGU5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 213DHPROSITE-ProRule annotationAdd BLAST184
Domaini254 – 455BARPROSITE-ProRule annotationAdd BLAST202
Domaini506 – 569SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini602 – 665SH3 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519 Eukaryota
ENOG410YAZC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155522

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103401

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1IGU5

KEGG Orthology (KO)

More...
KOi
K20710

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGPQNLI

Database of Orthologous Groups

More...
OrthoDBi
207472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1IGU5

TreeFam database of animal gene trees

More...
TreeFami
TF330015

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit
cd11799 SH3_ARHGEF37_C1, 1 hit
cd11941 SH3_ARHGEF37_C2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
1.20.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035636 ARHGEF37_SH3_2
IPR035823 ARHGEF37_SH3_C1
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51021 BAR, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A1IGU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ
60 70 80 90 100
LCASDIRSRL QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV
110 120 130 140 150
QLVGNIFLEF QEELEQVYKV YCASYDQALL LVDTYRKEPE LQRHIQGIVE
160 170 180 190 200
AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ KILENTVPDA SAYPVLQRAV
210 220 230 240 250
SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT HTLSKKTTRL
260 270 280 290 300
SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF
310 320 330 340 350
LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL
360 370 380 390 400
AKALLGPQNL IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS
410 420 430 440 450
LLVAELPQFN QLVMQWLGQI MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH
460 470 480 490 500
VPEPAFRKLV EDALGRTSNQ LRSFQETFEK VQPPPTTQPL LPGSERQVQA
510 520 530 540 550
LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD TKGNSGRWLV
560 570 580 590 600
DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS
610 620 630 640 650
IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG
660 670
QRGYVPSGFL ARARSPVLWG WSLPS
Length:675
Mass (Da):76,278
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90EC3F5B7BFA7178
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJH4D6RJH4_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF37
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC85655 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043579421M → L. Corresponds to variant dbSNP:rs4629585Ensembl.1
Natural variantiVAR_043580489P → L1 PublicationCorresponds to variant dbSNP:rs9324624Ensembl.1
Natural variantiVAR_043581518S → R. Corresponds to variant dbSNP:rs7732714Ensembl.1
Natural variantiVAR_043582586P → T. Corresponds to variant dbSNP:rs3733662Ensembl.1
Natural variantiVAR_043583604M → V1 PublicationCorresponds to variant dbSNP:rs1135093Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB199796 mRNA Translation: BAF43710.1
AK123597 mRNA Translation: BAC85655.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43385.1

NCBI Reference Sequences

More...
RefSeqi
NP_001001669.2, NM_001001669.2
XP_005268504.1, XM_005268447.4
XP_006714847.1, XM_006714784.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.256206

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333677; ENSP00000328083; ENSG00000183111

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389337

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389337

UCSC genome browser

More...
UCSCi
uc003lra.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199796 mRNA Translation: BAF43710.1
AK123597 mRNA Translation: BAC85655.1 Different initiation.
CCDSiCCDS43385.1
RefSeqiNP_001001669.2, NM_001001669.2
XP_005268504.1, XM_005268447.4
XP_006714847.1, XM_006714784.3
UniGeneiHs.256206

3D structure databases

ProteinModelPortaliA1IGU5
SMRiA1IGU5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133100, 2 interactors
STRINGi9606.ENSP00000328083

PTM databases

iPTMnetiA1IGU5
PhosphoSitePlusiA1IGU5

Polymorphism and mutation databases

BioMutaiARHGEF37

Proteomic databases

EPDiA1IGU5
jPOSTiA1IGU5
MaxQBiA1IGU5
PaxDbiA1IGU5
PRIDEiA1IGU5
ProteomicsDBi123

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333677; ENSP00000328083; ENSG00000183111
GeneIDi389337
KEGGihsa:389337
UCSCiuc003lra.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389337
EuPathDBiHostDB:ENSG00000183111.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGEF37
HGNCiHGNC:34430 ARHGEF37
HPAiHPA043885
HPA053487
neXtProtiNX_A1IGU5
OpenTargetsiENSG00000183111
PharmGKBiPA165660135

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
ENOG410YAZC LUCA
GeneTreeiENSGT00940000153542
HOGENOMiHOG000155522
HOVERGENiHBG103401
InParanoidiA1IGU5
KOiK20710
OMAiAGPQNLI
OrthoDBi207472at2759
PhylomeDBiA1IGU5
TreeFamiTF330015

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGEF37 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389337

Protein Ontology

More...
PROi
PR:A1IGU5

Gene expression databases

BgeeiENSG00000183111 Expressed in 203 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiA1IGU5 baseline and differential
GenevisibleiA1IGU5 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11799 SH3_ARHGEF37_C1, 1 hit
cd11941 SH3_ARHGEF37_C2, 1 hit
Gene3Di1.20.1270.60, 1 hit
1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035636 ARHGEF37_SH3_2
IPR035823 ARHGEF37_SH3_C1
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARH37_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1IGU5
Secondary accession number(s): Q6ZW51
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 16, 2019
This is version 90 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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