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Entry version 80 (08 May 2019)
Sequence version 1 (06 Feb 2007)
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Protein

Rho guanine nucleotide exchange factor 37

Gene

Arhgef37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045339 Arhgef37

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370511 – 676Rho guanine nucleotide exchange factor 37Add BLAST676

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A1IGU4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1IGU4

PeptideAtlas

More...
PeptideAtlasi
A1IGU4

PRoteomics IDEntifications database

More...
PRIDEi
A1IGU4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1IGU4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1IGU4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130560

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1IGU4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 213DHPROSITE-ProRule annotationAdd BLAST184
Domaini254 – 455BARPROSITE-ProRule annotationAdd BLAST202
Domaini506 – 569SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini603 – 666SH3 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519 Eukaryota
ENOG410YAZC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155522

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1IGU4

KEGG Orthology (KO)

More...
KOi
K20710

Database of Orthologous Groups

More...
OrthoDBi
207472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1IGU4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit
cd11799 SH3_ARHGEF37_C1, 1 hit
cd11941 SH3_ARHGEF37_C2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.60, 1 hit
1.20.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035636 ARHGEF37_SH3_2
IPR035823 ARHGEF37_SH3_C1
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03114 BAR, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51021 BAR, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A1IGU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR
60 70 80 90 100
LCASDIRSHL QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA
110 120 130 140 150
HLIGNLFLEF QEEFEQVYKV YCANYDQALL LVKAYQKEPE LQKEIQGIIE
160 170 180 190 200
AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ KILENTPADA SAHPALQRAT
210 220 230 240 250
SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT HTLSKKTTRL
260 270 280 290 300
SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF
310 320 330 340 350
LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL
360 370 380 390 400
ARALAGPQNL IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS
410 420 430 440 450
LLVAELPQFN QLVMQWLGQI LCTFVVLQRD LADQVLRRAE STMALLPHHH
460 470 480 490 500
VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK VLPPSTTQPL LPGSEHQMQA
510 520 530 540 550
LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD TKGNNSRWLV
560 570 580 590 600
DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP
610 620 630 640 650
TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN
660 670
GQRGYVPSNF LARTPSPTPW GWNLPS
Length:676
Mass (Da):76,524
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D9BD8BE17F4912D
GO
Isoform 2 (identifier: A1IGU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MADFGADEAS...EIQGIIEAAM → MVSTCLTATFSLR

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):60,435
Checksum:i77BDC02D960CEF78
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5R6E9Q5R6_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef37
676Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0338561 – 153MADFG…IEAAM → MVSTCLTATFSLR in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB199795 mRNA Translation: BAF43709.1
AK030242 mRNA Translation: BAC26861.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50302.1 [A1IGU4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_808496.2, NM_177828.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
328967

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:328967

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199795 mRNA Translation: BAF43709.1
AK030242 mRNA Translation: BAC26861.1
CCDSiCCDS50302.1 [A1IGU4-1]
RefSeqiNP_808496.2, NM_177828.4

3D structure databases

SMRiA1IGU4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130560

PTM databases

iPTMnetiA1IGU4
PhosphoSitePlusiA1IGU4

Proteomic databases

MaxQBiA1IGU4
PaxDbiA1IGU4
PeptideAtlasiA1IGU4
PRIDEiA1IGU4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi328967
KEGGimmu:328967

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389337
MGIiMGI:3045339 Arhgef37

Phylogenomic databases

eggNOGiKOG3519 Eukaryota
ENOG410YAZC LUCA
HOGENOMiHOG000155522
InParanoidiA1IGU4
KOiK20710
OrthoDBi207472at2759
PhylomeDBiA1IGU4

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A1IGU4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11799 SH3_ARHGEF37_C1, 1 hit
cd11941 SH3_ARHGEF37_C2, 1 hit
Gene3Di1.20.1270.60, 1 hit
1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR035636 ARHGEF37_SH3_2
IPR035823 ARHGEF37_SH3_C1
IPR004148 BAR_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARH37_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1IGU4
Secondary accession number(s): Q8C0M3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 8, 2019
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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