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Protein

Fibrous sheath CABYR-binding protein

Gene

Fscb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.2 Publications

GO - Molecular functioni

  • calcium ion binding Source: MGI

GO - Biological processi

  • negative regulation of protein sumoylation Source: UniProtKB

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrous sheath CABYR-binding protein
Alternative name(s):
PKA-phosphorylated calcium and CABYR-binding protein
Gene namesi
Name:FscbImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3646964 Fscb

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312251 – 1074Fibrous sheath CABYR-binding proteinAdd BLAST1074

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Phosphoserine1 Publication1
Modified residuei57Phosphoserine1 Publication1
Modified residuei186Phosphoserine1 Publication1
Modified residuei275Phosphoserine1 Publication1
Modified residuei365Phosphoserine1 Publication1
Modified residuei1020Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated by PKA upon spermatozoa capacitation conditions.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA1EGX6

PTM databases

iPTMnetiA1EGX6

Expressioni

Tissue specificityi

Expression is restricted to testis and epididymis, expressed by spermatozoa.2 Publications

Developmental stagei

First expressed at step 11 of spermatogenesis in the elongating spermatids, and subsequently incorporates into the flagellar principal piece of the sperm.1 Publication

Interactioni

Subunit structurei

Interacts with CABYR (PubMed:17855365). Interacts with ROPN1 and ROPN1L; the interaction increases upon spermatozoa capacitation conditions (PubMed:27398160).2 Publications

Structurei

3D structure databases

SMRiA1EGX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi484 – 763Pro-richSequence analysisAdd BLAST280

Phylogenomic databases

HOGENOMiHOG000112656
HOVERGENiHBG107930
InParanoidiA1EGX6

Sequencei

Sequence statusi: Complete.

A1EGX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEECEEPEEP ISLGRQEYRR RRRPSQPMVD KSQQTEITEK RKAMASVQPP
60 70 80 90 100
APKATHSIGN IPGSKDNYSR KEYESLRLSS QLQKTLMKRK HVQDMTDKSL
110 120 130 140 150
QTEPIVEEKV EVIFIDKTLK LEENTAGVGE IAPELPQSIP EVEIPTSRPT
160 170 180 190 200
SHLIDRSQQT SCTGDWSLIY ICPKEKVDKE QQTYFSELEI IIRSIPGSSM
210 220 230 240 250
TKSKEETIPI AQEDPLVEIN GSLEIEVLSP EELPDVMMSF TEGEISGELQ
260 270 280 290 300
ALSNGEATVK GELFLTEEIP IQAPSPAEET SAAETATTTA KDVVDIQAPP
310 320 330 340 350
ADKLSSVEAP ADISPTLVQG ALSDKPSDQQ YPQGTEMAPS ELPVEDLDPF
360 370 380 390 400
SEEVLEKVQA LTTDSMLEDL GIAESTIAEE TSGKVQHPLS EETSKEVPAE
410 420 430 440 450
VHFPIAADFE ESAILINEKF ATDEVFEEYK PPIIEEVSAD KATAEVQPPS
460 470 480 490 500
AEDASEEVAS SEVLPPSTEQ GTVEDLTAEV LSTPTEEGPT EVPPQPTEEG
510 520 530 540 550
PAEVPPPLSE EGPAEVPPAP AEEAPAEVLP PPAEEAPAEV PPPLTEEGPA
560 570 580 590 600
EVPPPLTEEG PAEVPLAPAE EVPAEFLPPP AEEVPAEVPP PLTEEGPAEV
610 620 630 640 650
PPPLTEEGPE EVPPLPAEEA PTKVPPSPAE KGSAEVSPPQ TEEGPAEVPP
660 670 680 690 700
PPAEEFPTEV PSSSAEEGSS EVPLPPTAER PEEAPPPATE EAPVEVLPPA
710 720 730 740 750
TEEAPVEVLP PATEEAPVEV QSPAAEEGLA EVPPPPTEES PTHDVPTEVQ
760 770 780 790 800
VPQAKESPGQ VLPLSGESTA EEASAQVQPP SFEKAPLESL PLEEVEKIHL
810 820 830 840 850
DNLPFEVQPL PTEDIAIGVP AESQALPADE NPAREDTVET QPSSFEGAPI
860 870 880 890 900
AENPIEAPLP ASEADTGRED SAVHPSSLGP TDEAPAEIQI LQTDDIPTEM
910 920 930 940 950
SPVENQPLPA EEGFPEVVSE EEATAAEVRF PLSEGAPAQE ATVEAQLTSV
960 970 980 990 1000
EESPKRASVD VQPLSPETPV EESPGVDLPL KTNEVTMQEF RVEKMPAEDS
1010 1020 1030 1040 1050
LPPSEQTPAD QVLLKEHRLS QVADISEKEL ESTTLTSDKM SEGIDSVPED
1060 1070
VSGTKDDQIS TFKIEGTIKI ELKN
Length:1,074
Mass (Da):114,979
Last modified:January 23, 2007 - v1
Checksum:iF45159A44CB8BCDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF133693 mRNA Translation: ABL63912.1
UniGeneiMm.189552

Similar proteinsi

Entry informationi

Entry nameiFSCB_MOUSE
AccessioniPrimary (citable) accession number: A1EGX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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