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Entry version 77 (12 Aug 2020)
Sequence version 1 (23 Jan 2007)
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Protein

HEAT repeat-containing protein 6

Gene

Heatr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Heatr6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1566204, Heatr6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371761 – 1252HEAT repeat-containing protein 6Add BLAST1252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei471PhosphoserineBy similarity1
Modified residuei474PhosphoserineBy similarity1
Modified residuei689PhosphothreonineCombined sources1
Modified residuei714PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A1EC95

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A1EC95

PeptideAtlas

More...
PeptideAtlasi
A1EC95

PRoteomics IDEntifications database

More...
PRIDEi
A1EC95

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
A1EC95

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1EC95

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1EC95

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000002542, Expressed in skeletal muscle tissue and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1EC95, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000003492

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati230 – 269HEAT 1Add BLAST40
Repeati524 – 562HEAT 2Add BLAST39
Repeati586 – 624HEAT 3Add BLAST39
Repeati630 – 667HEAT 4Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi386 – 396Poly-LysAdd BLAST11

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4535, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007141_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1EC95

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYGCLTG

Database of Orthologous Groups

More...
OrthoDBi
106835at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1EC95

TreeFam database of animal gene trees

More...
TreeFami
TF324244

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR025283, DUF4042

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13251, DUF4042, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1EC95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALPGSKLS ERVRTVGWQI SRPYFCHFFP IRITAPPATC SANKGFPELE
60 70 80 90 100
HARPCPKRCP GSISQAIHVG KMAAVQVAAS LPCEQPREAP RELSLEQNNG
110 120 130 140 150
FRRLSARLRA LQPDDSTVSR MEIHLLFDQL ISENYCEGGG VAPEDVSALL
160 170 180 190 200
VRACQLVPLN QNHLVSKVSQ LIHRLLNRLQ VIVDEQNLDF LLTYTISAIQ
210 220 230 240 250
QCSPWTHMEI LQALAALVYC NGSKCQKHLP DLLGKSGLLM KLSDVTHSDP
260 270 280 290 300
EVRRAAVHCM ANLCLSVPGQ PYLEESYQLV CFQAFLTILQ SPKSSDMDDI
310 320 330 340 350
TFCMLLQNAL KGIQSLLNGG KMRLTQTEHL GALLAVLKKA MFHGLPGLNI
360 370 380 390 400
EMPAVLYPTP LPQYDGRSPV KPQQPESSAA RPSANKKKKY KVKPKKTQQG
410 420 430 440 450
EKAEEEEPYG EVDAAPGLSM DQANTCVESA WCSSPWGSQG LPVDGGRATG
460 470 480 490 500
REQVSSPFTI SSWKRVSSSE SDYSDAEGGM QGKMRSYQAK VRQGALACFL
510 520 530 540 550
STIKSIEKKV LYGYWSAFVP DTPELGSPQS VSLMTLTLKD PSPKTRACAL
560 570 580 590 600
QVLSAILEGS KQFLSVAEDT SDHKRAFTPF SVTIASSIRE LHRCLLLALV
610 620 630 640 650
AESSSQTLTQ IIKCLANLVS NAPYNRLKLS LLTKVWNHIK PYIRHKDVNV
660 670 680 690 700
RVSSLTLLGA VVSTHAPLPE VQLLLQQPCS SGRSSSSATP HLSTPDGWKA
710 720 730 740 750
LPAGPSLEEA SLSSPKGTAE PCWLIRLCIS TVVLPKEDSC SGSDAGSALG
760 770 780 790 800
STYEPSPMRL EALQVLAHLA RGYFSMAQLY LMELGEVICK CMCEANPSIQ
810 820 830 840 850
LHGVKLLEEL GTGLIQQYKP DSSTAPEQRV PVHMVAMFWT AMLNGPLPRA
860 870 880 890 900
LQSTEHPTLQ ASACDALSSI LPEAFSSLPN DKQILCITML LGLNDSKNHL
910 920 930 940 950
VKAATSRALG VYVLFPCLRQ DVIFVADTAN AILMSLQDKS LNVRAKAAWS
960 970 980 990 1000
LGNLTDTLIV NMDTPDPSFQ DEFSGLLLLK MLQSAIQAST DKDKVKSNAV
1010 1020 1030 1040 1050
RALGNLLHFL QPSHIERPRF AEIIEESIQA LISTVVNEAA MKVRWNACYA
1060 1070 1080 1090 1100
MGNVFKNPAL PLGTAPWTSQ AYKALTSVVM SCKNFKVRIR SAAALSVPGR
1110 1120 1130 1140 1150
RAQYGSLEQF SQIWSALVTA LQRSEDTTDF LEFKYCASLR THVCQALLHL
1160 1170 1180 1190 1200
LGLASASDLP CIQETLTVNG DMIRSYILQF LKSGAGGDDP GAVHSPQERN
1210 1220 1230 1240 1250
QMVRVALRHI HSVQALAGDT AKGAIVGFLE DILTVHCDSS GERAVLRGSL

DQ
Length:1,252
Mass (Da):136,505
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2A60C675685CF76
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF122002 mRNA Translation: ABL63441.1
EF122003 mRNA Translation: ABL63442.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073366.1, NM_001079897.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000003492; ENSRNOP00000003492; ENSRNOG00000002542

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
497972

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:497972

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF122002 mRNA Translation: ABL63441.1
EF122003 mRNA Translation: ABL63442.1
RefSeqiNP_001073366.1, NM_001079897.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003492

PTM databases

CarbonylDBiA1EC95
iPTMnetiA1EC95
PhosphoSitePlusiA1EC95

Proteomic databases

jPOSTiA1EC95
PaxDbiA1EC95
PeptideAtlasiA1EC95
PRIDEiA1EC95

Genome annotation databases

EnsembliENSRNOT00000003492; ENSRNOP00000003492; ENSRNOG00000002542
GeneIDi497972
KEGGirno:497972

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63897
RGDi1566204, Heatr6

Phylogenomic databases

eggNOGiKOG4535, Eukaryota
GeneTreeiENSGT00390000016675
HOGENOMiCLU_007141_1_0_1
InParanoidiA1EC95
OMAiDYGCLTG
OrthoDBi106835at2759
PhylomeDBiA1EC95
TreeFamiTF324244

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A1EC95

Gene expression databases

BgeeiENSRNOG00000002542, Expressed in skeletal muscle tissue and 21 other tissues
GenevisibleiA1EC95, RN

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR025283, DUF4042
PfamiView protein in Pfam
PF13251, DUF4042, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEAT6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1EC95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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