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Protein
Submitted name:

Checkpoint and tumor suppressor protein 2

Gene

CHEK2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-GGA-351433 ATM mediated phosphorylation of repair proteins
R-GGA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-GGA-6804757 Regulation of TP53 Degradation
R-GGA-69473 G2/M DNA damage checkpoint
R-GGA-69541 Stabilization of p53
R-GGA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A

Names & Taxonomyi

Protein namesi
Submitted name:
Checkpoint and tumor suppressor protein 2Imported
Submitted name:
Checkpoint kinase 2Imported
Gene namesi
Name:CHEK2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000005695 Expressed in 10 organ(s), highest expression level in female gonad
ExpressionAtlasiA1EAT1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009122

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 152FHAInterPro annotationAdd BLAST63
Domaini197 – 463Protein kinaseInterPro annotationAdd BLAST267

Phylogenomic databases

eggNOGiKOG0615 Eukaryota
ENOG410YA63 LUCA
GeneTreeiENSGT00800000124190
HOGENOMiHOG000233016
HOVERGENiHBG108055
KOiK06641
OrthoDBiEOG091G0DVW
TreeFamiTF101082

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A1EAT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRETRSDAQ PSQGTQPSQG GTSSSSSASQ GASQSSSSSG TLSSLDTVPT
60 70 80 90 100
QELPSIPEDP EPDELVPQPW GRLFALGKGF SNWDCVNDEY WFGRDKSCDY
110 120 130 140 150
SFSKLGLSET GFYQNYSKKH FRIFREMGPK NSYVAYIEDH SANGTFINRE
160 170 180 190 200
LIGKGKRLPL THNSEIALSI QTNKVFVFSD LTVDDQLVFP REFREKYIMS
210 220 230 240 250
KTLGSGACGE VKLAFEKSTC NKVAVKIINK RKFMASGGRE ANPAFNINTE
260 270 280 290 300
IEILKKIDHP CLIKIKNFFE AEDYYIVLEL MEGGELYDRV SRPVKMKEAT
310 320 330 340 350
CKLYFYQMLL AVKYLHDNGI IHRDLKPENV LLSSSEETCL IKITDFGQSK
360 370 380 390 400
ILGETSLMKT LCGTPTYLAP EVLNSFGTAG YSRAVDCWSL GVILFVCLCG
410 420 430 440 450
YPPFNEQNTQ LSLKDQITRG EYTFISKEWK HVSNMALDLV KKLLVVDPSK
460 470 480 490 500
RFTIEEALEH PWLQDEDMKN TFQQLLAQTS ATMNPPQTSK MPVATRKRLH
510 520
ENEDESVSSK RDVPSTSLQK MR
Length:522
Mass (Da):58,798
Last modified:January 23, 2007 - v1
Checksum:i76D413B18C360C96
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PAM1A0A1D5PAM1_CHICK
Checkpoint kinase 2
CHEK2
524Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000193 Genomic DNA No translation available.
EF118300 mRNA Translation: ABL14109.1
RefSeqiNP_001073576.1, NM_001080107.1
UniGeneiGga.2517

Genome annotation databases

EnsembliENSGALT00000009136; ENSGALP00000009122; ENSGALG00000005695
GeneIDi768913
KEGGigga:768913

Similar proteinsi

Entry informationi

Entry nameiA1EAT1_CHICK
AccessioniPrimary (citable) accession number: A1EAT1
Secondary accession number(s): F1N864
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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