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Protein

Odontogenic ameloblast-associated protein

Gene

Odam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.By similarity

GO - Biological processi

Keywordsi

Biological processBiomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Odontogenic ameloblast-associated protein
Alternative name(s):
Apin
Gene namesi
Name:Odam
Synonyms:Apin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916842 Odam

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_500018388016 – 273Odontogenic ameloblast-associated proteinAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi118O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi159O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi240O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi241O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi247O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi252O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi258O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi267O-linked (GalNAc...) threonineSequence analysis1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1E960
PRIDEiA1E960

PTM databases

PhosphoSitePlusiA1E960

Expressioni

Tissue specificityi

Highly expressed in tooth-associated epithelia. Predominantly expressed in mandible.1 Publication

Gene expression databases

BgeeiENSMUSG00000009580 Expressed in 29 organ(s), highest expression level in molar tooth
CleanExiMM_ODAM
GenevisibleiA1E960 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with ARHGEF5.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108899

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 127Interaction with ARHGEF5By similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 196Gln-richAdd BLAST135

Sequence similaritiesi

Belongs to the ODAM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IV9J Eukaryota
ENOG411182C LUCA
GeneTreeiENSGT00390000011100
HOGENOMiHOG000115257
HOVERGENiHBG096669
InParanoidiA1E960
OMAiFNSWIPP
OrthoDBiEOG091G0RVL
PhylomeDBiA1E960
TreeFamiTF338424

Family and domain databases

InterProiView protein in InterPro
IPR026802 Odam
PANTHERiPTHR16237 PTHR16237, 1 hit
PfamiView protein in Pfam
PF15424 ODAM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1E960-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIIILLGLI GASSSAPLIS QRLLSASNSH ELLLNLNNGQ LLPLQFQGAF
60 70 80 90 100
NSWIPPFPGF LQQQQAQVSG RPQFTLSTLE SFAGLFPNQI PLSRQVGLAQ
110 120 130 140 150
GGQAGQPDLS QQQTPPQTQQ SASPMSYVVP VKVPQDQTQM FQYYPVYMLL
160 170 180 190 200
PWEQPQTVTS SPQHTGQQLF EEQIPFYNQF GFAPPQAEPG VPGGQQHLAF
210 220 230 240 250
DSFVGTAPET PGMPVEGSLL YPQKEPISFK HDNAGVFMPT TSPKPSTDNF
260 270
FTSGIDPTIA PEQKVKTDSL REP
Length:273
Mass (Da):29,820
Last modified:January 23, 2007 - v1
Checksum:iCA8B395AE68985B6
GO

Sequence cautioni

The sequence AAI32395 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32397 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB26200 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113909 mRNA Translation: ABL11578.1
AK009298 mRNA Translation: BAB26200.1 Different initiation.
BC132394 mRNA Translation: AAI32395.1 Different initiation.
BC132396 mRNA Translation: AAI32397.1 Different initiation.
CCDSiCCDS19394.2
RefSeqiNP_081404.2, NM_027128.2
XP_006535273.1, XM_006535210.3
UniGeneiMm.389652

Genome annotation databases

EnsembliENSMUST00000113274; ENSMUSP00000108899; ENSMUSG00000009580
ENSMUST00000129757; ENSMUSP00000117898; ENSMUSG00000009580
GeneIDi69592
KEGGimmu:69592
UCSCiuc008xzd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113909 mRNA Translation: ABL11578.1
AK009298 mRNA Translation: BAB26200.1 Different initiation.
BC132394 mRNA Translation: AAI32395.1 Different initiation.
BC132396 mRNA Translation: AAI32397.1 Different initiation.
CCDSiCCDS19394.2
RefSeqiNP_081404.2, NM_027128.2
XP_006535273.1, XM_006535210.3
UniGeneiMm.389652

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108899

PTM databases

PhosphoSitePlusiA1E960

Proteomic databases

PaxDbiA1E960
PRIDEiA1E960

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113274; ENSMUSP00000108899; ENSMUSG00000009580
ENSMUST00000129757; ENSMUSP00000117898; ENSMUSG00000009580
GeneIDi69592
KEGGimmu:69592
UCSCiuc008xzd.1 mouse

Organism-specific databases

CTDi54959
MGIiMGI:1916842 Odam

Phylogenomic databases

eggNOGiENOG410IV9J Eukaryota
ENOG411182C LUCA
GeneTreeiENSGT00390000011100
HOGENOMiHOG000115257
HOVERGENiHBG096669
InParanoidiA1E960
OMAiFNSWIPP
OrthoDBiEOG091G0RVL
PhylomeDBiA1E960
TreeFamiTF338424

Miscellaneous databases

PROiPR:A1E960
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009580 Expressed in 29 organ(s), highest expression level in molar tooth
CleanExiMM_ODAM
GenevisibleiA1E960 MM

Family and domain databases

InterProiView protein in InterPro
IPR026802 Odam
PANTHERiPTHR16237 PTHR16237, 1 hit
PfamiView protein in Pfam
PF15424 ODAM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiODAM_MOUSE
AccessioniPrimary (citable) accession number: A1E960
Secondary accession number(s): Q9D7E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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