UniProtKB - A1E959 (ODAM_HUMAN)
Protein
Odontogenic ameloblast-associated protein
Gene
ODAM
Organism
Homo sapiens (Human)
Status
Functioni
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.1 Publication
Miscellaneous
ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.
GO - Biological processi
- biomineral tissue development Source: UniProtKB-KW
- cellular protein metabolic process Source: Reactome
- inflammatory response Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: HGNC-UCL
- positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- regulation of actin cytoskeleton organization Source: UniProtKB
Keywordsi
Biological process | Biomineralization |
Enzyme and pathway databases
PathwayCommonsi | A1E959 |
Reactomei | R-HSA-977225, Amyloid fiber formation |
Names & Taxonomyi
Protein namesi | Recommended name: Odontogenic ameloblast-associated proteinAlternative name(s): Apin |
Gene namesi | Name:ODAM Synonyms:APIN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109205.16 |
HGNCi | HGNC:26043, ODAM |
MIMi | 614843, gene |
neXtProti | NX_A1E959 |
Subcellular locationi
Cytoskeleton
- mitotic spindle Source: HPA
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cell periphery Source: UniProtKB
- cytoplasm Source: UniProtKB
- supramolecular fiber Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 54959 |
OpenTargetsi | ENSG00000109205 |
PharmGKBi | PA145148342 |
Miscellaneous databases
Pharosi | A1E959, Tbio |
Polymorphism and mutation databases
BioMutai | ODAM |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5000183879 | 16 – 279 | Odontogenic ameloblast-associated proteinAdd BLAST | 264 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 115 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 119 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 244 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 249 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 250 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 251 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 255 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 256 | O-linked (GalNAc...) serineSequence analysis | 1 | |
Glycosylationi | 261 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 263 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 273 | O-linked (GalNAc...) threonineSequence analysis | 1 | |
Glycosylationi | 275 | O-linked (GalNAc...) serineSequence analysis | 1 |
Post-translational modificationi
O-glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | A1E959 |
PaxDbi | A1E959 |
PeptideAtlasi | A1E959 |
PRIDEi | A1E959 |
ProteomicsDBi | 122 |
PTM databases
GlyGeni | A1E959, 12 sites |
iPTMneti | A1E959 |
PhosphoSitePlusi | A1E959 |
Expressioni
Tissue specificityi
Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.1 Publication
Gene expression databases
Bgeei | ENSG00000109205, Expressed in minor salivary gland and 116 other tissues |
ExpressionAtlasi | A1E959, baseline and differential |
Genevisiblei | A1E959, HS |
Organism-specific databases
HPAi | ENSG00000109205, Tissue enriched (salivary) |
Interactioni
Subunit structurei
Interacts (via C-terminus) with ARHGEF5.
1 PublicationBinary interactionsi
Hide detailsA1E959
Protein-protein interaction databases
BioGRIDi | 120297, 15 interactors |
IntActi | A1E959, 13 interactors |
MINTi | A1E959 |
STRINGi | 9606.ENSP00000379401 |
Miscellaneous databases
RNActi | A1E959, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 129 | Interaction with ARHGEF51 Publication | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 62 – 206 | Gln-richAdd BLAST | 145 |
Sequence similaritiesi
Belongs to the ODAM family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RM1P, Eukaryota |
GeneTreei | ENSGT00390000011100 |
HOGENOMi | CLU_096142_0_0_1 |
InParanoidi | A1E959 |
OMAi | NHVMPYV |
OrthoDBi | 1237925at2759 |
PhylomeDBi | A1E959 |
TreeFami | TF338424 |
Family and domain databases
InterProi | View protein in InterPro IPR026802, Odam |
PANTHERi | PTHR16237, PTHR16237, 1 hit |
Pfami | View protein in Pfam PF15424, ODAM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A1E959-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL
60 70 80 90 100
NSWIPPFSGI LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA
110 120 130 140 150
QGAQAGQVDP LQLQTPPQTQ PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM
160 170 180 190 200
VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY AQFGYIPQLA EPAISGGQQQ
210 220 230 240 250
LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF MPSTSPKPST
260 270
TNVFTSAVDQ TITPELPEEK DKTDSLREP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YA46 | H0YA46_HUMAN | Apin | ODAM | 216 | Annotation score: | ||
D6RA81 | D6RA81_HUMAN | Apin | ODAM | 253 | Annotation score: | ||
H0Y8T7 | H0Y8T7_HUMAN | Apin | ODAM | 30 | Annotation score: |
Sequence cautioni
The sequence BAA91226 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039812 | 222 | I → T1 PublicationCorresponds to variant dbSNP:rs3196714Ensembl. | 1 | |
Natural variantiVAR_039813 | 269 | E → D in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF113908 mRNA Translation: ABL11577.1 CH471057 Genomic DNA Translation: EAX05612.1 AK000520 mRNA Translation: BAA91226.1 Different initiation. BC017796 mRNA Translation: AAH17796.1 |
CCDSi | CCDS3536.2 |
RefSeqi | NP_060325.3, NM_017855.3 |
Genome annotation databases
Ensembli | ENST00000396094; ENSP00000379401; ENSG00000109205 |
GeneIDi | 54959 |
KEGGi | hsa:54959 |
UCSCi | uc003hfc.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF113908 mRNA Translation: ABL11577.1 CH471057 Genomic DNA Translation: EAX05612.1 AK000520 mRNA Translation: BAA91226.1 Different initiation. BC017796 mRNA Translation: AAH17796.1 |
CCDSi | CCDS3536.2 |
RefSeqi | NP_060325.3, NM_017855.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120297, 15 interactors |
IntActi | A1E959, 13 interactors |
MINTi | A1E959 |
STRINGi | 9606.ENSP00000379401 |
PTM databases
GlyGeni | A1E959, 12 sites |
iPTMneti | A1E959 |
PhosphoSitePlusi | A1E959 |
Polymorphism and mutation databases
BioMutai | ODAM |
Proteomic databases
MassIVEi | A1E959 |
PaxDbi | A1E959 |
PeptideAtlasi | A1E959 |
PRIDEi | A1E959 |
ProteomicsDBi | 122 |
Protocols and materials databases
Antibodypediai | 24311, 28 antibodies |
DNASUi | 54959 |
Genome annotation databases
Ensembli | ENST00000396094; ENSP00000379401; ENSG00000109205 |
GeneIDi | 54959 |
KEGGi | hsa:54959 |
UCSCi | uc003hfc.4, human |
Organism-specific databases
CTDi | 54959 |
DisGeNETi | 54959 |
EuPathDBi | HostDB:ENSG00000109205.16 |
GeneCardsi | ODAM |
HGNCi | HGNC:26043, ODAM |
HPAi | ENSG00000109205, Tissue enriched (salivary) |
MIMi | 614843, gene |
neXtProti | NX_A1E959 |
OpenTargetsi | ENSG00000109205 |
PharmGKBi | PA145148342 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RM1P, Eukaryota |
GeneTreei | ENSGT00390000011100 |
HOGENOMi | CLU_096142_0_0_1 |
InParanoidi | A1E959 |
OMAi | NHVMPYV |
OrthoDBi | 1237925at2759 |
PhylomeDBi | A1E959 |
TreeFami | TF338424 |
Enzyme and pathway databases
PathwayCommonsi | A1E959 |
Reactomei | R-HSA-977225, Amyloid fiber formation |
Miscellaneous databases
BioGRID-ORCSi | 54959, 5 hits in 838 CRISPR screens |
ChiTaRSi | ODAM, human |
GeneWikii | ODAM_(gene) |
GenomeRNAii | 54959 |
Pharosi | A1E959, Tbio |
PROi | PR:A1E959 |
RNActi | A1E959, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109205, Expressed in minor salivary gland and 116 other tissues |
ExpressionAtlasi | A1E959, baseline and differential |
Genevisiblei | A1E959, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026802, Odam |
PANTHERi | PTHR16237, PTHR16237, 1 hit |
Pfami | View protein in Pfam PF15424, ODAM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ODAM_HUMAN | |
Accessioni | A1E959Primary (citable) accession number: A1E959 Secondary accession number(s): Q8WWE5, Q9NWZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations