UniProtKB - A1E959 (ODAM_HUMAN)

BLAST

>sp|A1E959|ODAM_HUMAN Odontogenic ameloblast-associated protein OS=Homo sapiens OX=9606 GN=ODAM PE=1 SV=1
MKIIILLGFLGATLSAPLIPQRLMSASNSNELLLNLNNGQLLPLQLQGPLNSWIPPFSGI
LQQQQQAQIPGLSQFSLSALDQFAGLLPNQIPLTGEASFAQGAQAGQVDPLQLQTPPQTQ
PGPSHVMPYVFSFKMPQEQGQMFQYYPVYMVLPWEQPQQTVPRSPQQTRQQQYEEQIPFY
AQFGYIPQLAEPAISGGQQQLAFDPQLGTAPEIAVMSTGEEIPYLQKEAINFRHDSAGVF
MPSTSPKPSTTNVFTSAVDQTITPELPEEKDKTDSLREP

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History
Entry version 92 (07 Nov 2018)
Sequence version 1 (23 Jan 2007)
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Protein

Odontogenic ameloblast-associated protein

Gene

ODAM

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.1 Publication

Miscellaneous

ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.

GO - Biological processⁱ

biomineral tissue development Source: UniProtKB-KW
cellular protein metabolic process Source: Reactome
inflammatory response
Source: UniProtKB
Inferred from direct assayⁱ
- 25911094
odontogenesis of dentin-containing tooth
Source: HGNC
Inferred from expression patternⁱ
- 16674676
positive regulation of epithelial cell proliferation involved in wound healing
Source: UniProtKB
Inferred from expression patternⁱ
- 25911094
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25911094
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25911094
positive regulation of protein phosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25911094
regulation of actin cytoskeleton organization
Source: UniProtKB
Inferred from direct assayⁱ
- 25911094

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Biomineralization

Biological process

Biomineralization

Enzyme and pathway databases

Reactomeⁱ	R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-977225 Amyloid fiber formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Odontogenic ameloblast-associated protein Alternative name(s): Apin
Gene namesⁱ	Name:ODAM Synonyms:APIN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000109205.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26043 ODAM
MIMⁱ	614843 gene
neXtProtⁱ	NX_A1E959

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54959
Open Targets More...OpenTargetsⁱ	ENSG00000109205
PharmGKBⁱ	PA145148342

Polymorphism and mutation databases

BioMutaⁱ	ODAM

BioMutaⁱ

ODAM

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 15	Sequence analysisAdd BLAST		15
ChainⁱPRO_5000183879	16 – 279	Odontogenic ameloblast-associated proteinAdd BLAST		264

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	115	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	119	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	244	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	249	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	250	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	251	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	255	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	256	O-linked (GalNAc...) serineSequence analysis	1
Glycosylationⁱ	261	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	263	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	273	O-linked (GalNAc...) threonineSequence analysis	1
Glycosylationⁱ	275	O-linked (GalNAc...) serineSequence analysis	1

Post-translational modificationⁱ

O-glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	A1E959
PRIDEⁱ	A1E959
ProteomicsDBⁱ	122

PTM databases

iPTMnetⁱ	A1E959
PhosphoSitePlusⁱ	A1E959

Expressionⁱ

Tissue specificityⁱ

Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000109205 Expressed in 88 organ(s), highest expression level in minor salivary gland
CleanExⁱ	HS_ODAM
ExpressionAtlasⁱ	A1E959 baseline and differential
Genevisibleⁱ	A1E959 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036543

HPAⁱ

HPA036543

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with ARHGEF5.1 Publication

Protein-protein interaction databases

BioGridⁱ	120297, 5 interactors
IntActⁱ	A1E959, 13 interactors
Molecular INTeraction database More...MINTⁱ	A1E959
STRINGⁱ	9606.ENSP00000379401

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1E959
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	127 – 129	Interaction with ARHGEF51 Publication		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	62 – 206	Gln-richAdd BLAST		145

Sequence similaritiesⁱ

Belongs to the ODAM family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IV9J Eukaryota ENOG411182C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011100
HOGENOMⁱ	HOG000115257
HOVERGENⁱ	HBG096669
InParanoidⁱ	A1E959
OMAⁱ	FNSWIPP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RVL
PhylomeDBⁱ	A1E959
TreeFamⁱ	TF338424

Family and domain databases

InterProⁱ	View protein in InterPro IPR026802 Odam
PANTHERⁱ	PTHR16237 PTHR16237, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15424 ODAM, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

A1E959-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL 
        60         70         80         90        100
NSWIPPFSGI LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA 
       110        120        130        140        150
QGAQAGQVDP LQLQTPPQTQ PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM 
       160        170        180        190        200
VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY AQFGYIPQLA EPAISGGQQQ 
       210        220        230        240        250
LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF MPSTSPKPST 
       260        270 
TNVFTSAVDQ TITPELPEEK DKTDSLREP

Length:279

Mass (Da):30,777

Last modified:January 23, 2007 - v1

Checksum:ⁱDE0E42076B572318

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RA81	D6RA81_HUMAN	Odontogenic ameloblast-associated p... Odontogenic ameloblast-associated protein	ODAM	253	Annotation score:
H0YA46	H0YA46_HUMAN	Odontogenic ameloblast-associated p... Odontogenic ameloblast-associated protein	ODAM	216	Annotation score:
H0Y8T7	H0Y8T7_HUMAN	Odontogenic ameloblast-associated p... Odontogenic ameloblast-associated protein	ODAM	30	Annotation score:

Sequence cautionⁱ

The sequence BAA91226 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039812	222	I → T1 PublicationCorresponds to variant dbSNP:rs3196714Ensembl.		1
Natural variantⁱVAR_039813	269	E → D in a colorectal cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF113908 mRNA Translation: ABL11577.1 CH471057 Genomic DNA Translation: EAX05612.1 AK000520 mRNA Translation: BAA91226.1 Different initiation. BC017796 mRNA Translation: AAH17796.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3536.2
NCBI Reference Sequences More...RefSeqⁱ	NP_060325.3, NM_017855.3
UniGeneⁱ	Hs.143811

Genome annotation databases

Ensemblⁱ	ENST00000396094; ENSP00000379401; ENSG00000109205
GeneIDⁱ	54959
KEGGⁱ	hsa:54959
UCSC genome browser More...UCSCⁱ	uc003hfc.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A1E959	Odontogenic ameloblast-associated protein		MACMU		279	UniRef90_A1E959
Odontogenic ameloblast-associated protein		PANTR		279
Odontogenic, ameloblast associated		CHLSB		279
Apin		MACFA		279
Uncharacterized protein		PONAB		279
+26

Protein	Similar proteins		Species	Score	Length	Source
A1E959	Odontogenic ameloblast-associated protein		MACMU		279	UniRef50_A1E959
Odontogenic ameloblast-associated protein		PANTR		279
Odontogenic ameloblast-associated protein		CANLF		278
Odontogenic ameloblast-associated protein		PIG		276
Odontogenic ameloblast-associated protein		MOUSE		273
+104

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF113908 mRNA Translation: ABL11577.1 CH471057 Genomic DNA Translation: EAX05612.1 AK000520 mRNA Translation: BAA91226.1 Different initiation. BC017796 mRNA Translation: AAH17796.1
CCDSⁱ	CCDS3536.2
RefSeqⁱ	NP_060325.3, NM_017855.3
UniGeneⁱ	Hs.143811

3D structure databases

ProteinModelPortalⁱ	A1E959
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120297, 5 interactors
IntActⁱ	A1E959, 13 interactors
MINTⁱ	A1E959
STRINGⁱ	9606.ENSP00000379401

PTM databases

iPTMnetⁱ	A1E959
PhosphoSitePlusⁱ	A1E959

Polymorphism and mutation databases

BioMutaⁱ	ODAM

BioMutaⁱ

ODAM

Proteomic databases

PaxDbⁱ	A1E959
PRIDEⁱ	A1E959
ProteomicsDBⁱ	122

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54959
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000396094; ENSP00000379401; ENSG00000109205
GeneIDⁱ	54959
KEGGⁱ	hsa:54959
UCSCⁱ	uc003hfc.4 human

Organism-specific databases

CTDⁱ	54959
DisGeNETⁱ	54959
EuPathDBⁱ	HostDB:ENSG00000109205.16
GeneCardsⁱ	ODAM
HGNCⁱ	HGNC:26043 ODAM
HPAⁱ	HPA036543
MIMⁱ	614843 gene
neXtProtⁱ	NX_A1E959
OpenTargetsⁱ	ENSG00000109205
PharmGKBⁱ	PA145148342
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IV9J Eukaryota ENOG411182C LUCA
GeneTreeⁱ	ENSGT00390000011100
HOGENOMⁱ	HOG000115257
HOVERGENⁱ	HBG096669
InParanoidⁱ	A1E959
OMAⁱ	FNSWIPP
OrthoDBⁱ	EOG091G0RVL
PhylomeDBⁱ	A1E959
TreeFamⁱ	TF338424

Enzyme and pathway databases

Reactomeⁱ	R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

GeneWikiⁱ	ODAM_(gene)
GenomeRNAiⁱ	54959
Protein Ontology More...PROⁱ	PR:A1E959
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109205 Expressed in 88 organ(s), highest expression level in minor salivary gland
CleanExⁱ	HS_ODAM
ExpressionAtlasⁱ	A1E959 baseline and differential
Genevisibleⁱ	A1E959 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026802 Odam
PANTHERⁱ	PTHR16237 PTHR16237, 1 hit
Pfamⁱ	View protein in Pfam PF15424 ODAM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ODAM_HUMAN
Accessionⁱ	A1E959Primary (citable) accession number: A1E959 Secondary accession number(s): Q8WWE5, Q9NWZ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - A1E959 (ODAM_HUMAN)

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Odontogenic ameloblast-associated protein

ODAM

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Extracellular region or secreted

Other locations

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ