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Protein

Odontogenic ameloblast-associated protein

Gene

ODAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.1 Publication

Miscellaneous

ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.

GO - Biological processi

Keywordsi

Biological processBiomineralization

Enzyme and pathway databases

ReactomeiR-HSA-977225 Amyloid fiber formation

Names & Taxonomyi

Protein namesi
Recommended name:
Odontogenic ameloblast-associated protein
Alternative name(s):
Apin
Gene namesi
Name:ODAM
Synonyms:APIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109205.16
HGNCiHGNC:26043 ODAM
MIMi614843 gene
neXtProtiNX_A1E959

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi54959
OpenTargetsiENSG00000109205
PharmGKBiPA145148342

Polymorphism and mutation databases

BioMutaiODAM

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_500018387916 – 279Odontogenic ameloblast-associated proteinAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi119O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi244O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi249O-linked (GalNAc...) serineSequence analysis1
Glycosylationi250O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi251O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi255O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi256O-linked (GalNAc...) serineSequence analysis1
Glycosylationi261O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi263O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi273O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi275O-linked (GalNAc...) serineSequence analysis1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1E959
PRIDEiA1E959
ProteomicsDBi122

PTM databases

iPTMnetiA1E959
PhosphoSitePlusiA1E959

Expressioni

Tissue specificityi

Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.1 Publication

Gene expression databases

BgeeiENSG00000109205 Expressed in 88 organ(s), highest expression level in minor salivary gland
CleanExiHS_ODAM
ExpressionAtlasiA1E959 baseline and differential
GenevisibleiA1E959 HS

Organism-specific databases

HPAiHPA036543

Interactioni

Subunit structurei

Interacts (via C-terminus) with ARHGEF5.1 Publication

Protein-protein interaction databases

BioGridi120297, 5 interactors
IntActiA1E959, 13 interactors
MINTiA1E959
STRINGi9606.ENSP00000379401

Structurei

3D structure databases

ProteinModelPortaliA1E959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Interaction with ARHGEF51 Publication3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 206Gln-richAdd BLAST145

Sequence similaritiesi

Belongs to the ODAM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IV9J Eukaryota
ENOG411182C LUCA
GeneTreeiENSGT00390000011100
HOGENOMiHOG000115257
HOVERGENiHBG096669
InParanoidiA1E959
OMAiFNSWIPP
OrthoDBiEOG091G0RVL
PhylomeDBiA1E959
TreeFamiTF338424

Family and domain databases

InterProiView protein in InterPro
IPR026802 Odam
PANTHERiPTHR16237 PTHR16237, 1 hit
PfamiView protein in Pfam
PF15424 ODAM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A1E959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL
60 70 80 90 100
NSWIPPFSGI LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA
110 120 130 140 150
QGAQAGQVDP LQLQTPPQTQ PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM
160 170 180 190 200
VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY AQFGYIPQLA EPAISGGQQQ
210 220 230 240 250
LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF MPSTSPKPST
260 270
TNVFTSAVDQ TITPELPEEK DKTDSLREP
Length:279
Mass (Da):30,777
Last modified:January 23, 2007 - v1
Checksum:iDE0E42076B572318
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA81D6RA81_HUMAN
Odontogenic ameloblast-associated p...
ODAM
253Annotation score:
H0YA46H0YA46_HUMAN
Odontogenic ameloblast-associated p...
ODAM
216Annotation score:
H0Y8T7H0Y8T7_HUMAN
Odontogenic ameloblast-associated p...
ODAM
30Annotation score:

Sequence cautioni

The sequence BAA91226 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039812222I → T1 PublicationCorresponds to variant dbSNP:rs3196714Ensembl.1
Natural variantiVAR_039813269E → D in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113908 mRNA Translation: ABL11577.1
CH471057 Genomic DNA Translation: EAX05612.1
AK000520 mRNA Translation: BAA91226.1 Different initiation.
BC017796 mRNA Translation: AAH17796.1
CCDSiCCDS3536.2
RefSeqiNP_060325.3, NM_017855.3
UniGeneiHs.143811

Genome annotation databases

EnsembliENST00000396094; ENSP00000379401; ENSG00000109205
GeneIDi54959
KEGGihsa:54959
UCSCiuc003hfc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113908 mRNA Translation: ABL11577.1
CH471057 Genomic DNA Translation: EAX05612.1
AK000520 mRNA Translation: BAA91226.1 Different initiation.
BC017796 mRNA Translation: AAH17796.1
CCDSiCCDS3536.2
RefSeqiNP_060325.3, NM_017855.3
UniGeneiHs.143811

3D structure databases

ProteinModelPortaliA1E959
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120297, 5 interactors
IntActiA1E959, 13 interactors
MINTiA1E959
STRINGi9606.ENSP00000379401

PTM databases

iPTMnetiA1E959
PhosphoSitePlusiA1E959

Polymorphism and mutation databases

BioMutaiODAM

Proteomic databases

PaxDbiA1E959
PRIDEiA1E959
ProteomicsDBi122

Protocols and materials databases

DNASUi54959
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396094; ENSP00000379401; ENSG00000109205
GeneIDi54959
KEGGihsa:54959
UCSCiuc003hfc.4 human

Organism-specific databases

CTDi54959
DisGeNETi54959
EuPathDBiHostDB:ENSG00000109205.16
GeneCardsiODAM
HGNCiHGNC:26043 ODAM
HPAiHPA036543
MIMi614843 gene
neXtProtiNX_A1E959
OpenTargetsiENSG00000109205
PharmGKBiPA145148342
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV9J Eukaryota
ENOG411182C LUCA
GeneTreeiENSGT00390000011100
HOGENOMiHOG000115257
HOVERGENiHBG096669
InParanoidiA1E959
OMAiFNSWIPP
OrthoDBiEOG091G0RVL
PhylomeDBiA1E959
TreeFamiTF338424

Enzyme and pathway databases

ReactomeiR-HSA-977225 Amyloid fiber formation

Miscellaneous databases

GeneWikiiODAM_(gene)
GenomeRNAii54959
PROiPR:A1E959
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109205 Expressed in 88 organ(s), highest expression level in minor salivary gland
CleanExiHS_ODAM
ExpressionAtlasiA1E959 baseline and differential
GenevisibleiA1E959 HS

Family and domain databases

InterProiView protein in InterPro
IPR026802 Odam
PANTHERiPTHR16237 PTHR16237, 1 hit
PfamiView protein in Pfam
PF15424 ODAM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiODAM_HUMAN
AccessioniPrimary (citable) accession number: A1E959
Secondary accession number(s): Q8WWE5, Q9NWZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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