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Entry version 94 (02 Jun 2021)
Sequence version 1 (23 Jan 2007)
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Protein

Cathepsin B

Gene

CTSB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity).

Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity).

Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity).

Has also been implicated in tumor invasion and metastasis (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.By similarity EC:3.4.22.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei108PROSITE-ProRule annotation1
Active sitei278PROSITE-ProRule annotation1
Active sitei298PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-1442490, Collagen degradation
R-SSC-1679131, Trafficking and processing of endosomal TLR
R-SSC-2022090, Assembly of collagen fibrils and other multimeric structures
R-SSC-2132295, MHC class II antigen presentation
R-SSC-6798695, Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C01.060

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cathepsin B (EC:3.4.22.1By similarity)
Cleaved into the following 2 chains:
Cathepsin B light chainBy similarity
Cathepsin B heavy chainBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000008227 Componenti: Chromosome 14

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:87074, CTSB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Lysosome, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000033088518 – 79Activation peptideBy similarityAdd BLAST62
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033088680 – 332Cathepsin BAdd BLAST253
ChainiPRO_000033088780 – 126Cathepsin B light chainBy similarityAdd BLAST47
ChainiPRO_0000330888129 – 332Cathepsin B heavy chainBy similarityAdd BLAST204
PropeptideiPRO_0000330889333 – 335By similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi93 ↔ 122By similarity
Disulfide bondi105 ↔ 150By similarity
Disulfide bondi141 ↔ 207By similarity
Disulfide bondi142 ↔ 146By similarity
Disulfide bondi179 ↔ 211By similarity
Disulfide bondi187 ↔ 198By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192N-linked (GlcNAc...) asparagineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei220N6-acetyllysineBy similarity1
Disulfide bondi227 ↔ 331By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1E295

PeptideAtlas

More...
PeptideAtlasi
A1E295

PRoteomics IDEntifications database

More...
PRIDEi
A1E295

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000023666, Expressed in kidney and 49 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1E295, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1E295, SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

Interacts with SRPX2. Directly interacts with SHKBP1.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A1E295, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000024395

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1E295

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1543, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012184_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1E295

Database of Orthologous Groups

More...
OrthoDBi
865289at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314576

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR025661, Pept_asp_AS
IPR000169, Pept_cys_AS
IPR025660, Pept_his_AS
IPR000668, Peptidase_C1A_C
IPR012599, Propeptide_C1A

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00112, Peptidase_C1, 1 hit
PF08127, Propeptide_C1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00705, PAPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00645, Pept_C1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00640, THIOL_PROTEASE_ASN, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit
PS00639, THIOL_PROTEASE_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A1E295-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRLLATLSC LVLLTSARES LHFQPLSDEL VNFINKQNTT WTAGHNFYNV
60 70 80 90 100
DLSYVKKLCG TFLGGPKLPQ RAAFAADMIL PKSFDAREQW PNCPTIKEIR
110 120 130 140 150
DQGSCGSCWA FGAVEAISDR ICIRSNGRVN VEVSAEDMLT CCGDECGDGC
160 170 180 190 200
NGGFPSGAWN FWTKKGLVSG GLYDSHVGCR PYSIPPCEHH VNGSRPPCTG
210 220 230 240 250
EGDTPKCSKI CEPGYTPSYK EDKHFGCSSY SISRNEKEIM AEIYKNGPVE
260 270 280 290 300
GAFTVYSDFL QYKSGVYQHV TGDLMGGHAI RILGWGVENG TPYWLVGNSW
310 320 330
NTDWGDNGFF KILRGQDHCG IESEIVAGIP CTPHF
Length:335
Mass (Da):36,901
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD94E13E44822C19D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5S6GR81A0A5S6GR81_PIG
Cathepsin B
CTSB
416Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287BF94A0A287BF94_PIG
Cathepsin B
CTSB
367Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF095956 mRNA Translation: ABK96810.1

NCBI Reference Sequences

More...
RefSeqi
NP_001090927.1, NM_001097458.1
XP_005657322.2, XM_005657265.2
XP_005657323.1, XM_005657266.2
XP_005657324.1, XM_005657267.2
XP_013845747.1, XM_013990293.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000049406; ENSSSCP00000046743; ENSSSCG00000023666
ENSSSCT00015003893; ENSSSCP00015001345; ENSSSCG00015002579
ENSSSCT00015003921; ENSSSCP00015001359; ENSSSCG00015002579
ENSSSCT00025035776; ENSSSCP00025014937; ENSSSCG00025026366
ENSSSCT00030004003; ENSSSCP00030001587; ENSSSCG00030002799
ENSSSCT00035095352; ENSSSCP00035040101; ENSSSCG00035070519
ENSSSCT00040104061; ENSSSCP00040047304; ENSSSCG00040075101
ENSSSCT00045032170; ENSSSCP00045022270; ENSSSCG00045018627
ENSSSCT00045032247; ENSSSCP00045022327; ENSSSCG00045018627
ENSSSCT00045032316; ENSSSCP00045022379; ENSSSCG00045018627
ENSSSCT00045032398; ENSSSCP00045022441; ENSSSCG00045018627
ENSSSCT00045032468; ENSSSCP00045022486; ENSSSCG00045018627
ENSSSCT00050073267; ENSSSCP00050031547; ENSSSCG00050053741
ENSSSCT00055000049; ENSSSCP00055000041; ENSSSCG00055000027
ENSSSCT00060041735; ENSSSCP00060017740; ENSSSCG00060030710
ENSSSCT00065036005; ENSSSCP00065015077; ENSSSCG00065026769
ENSSSCT00065036011; ENSSSCP00065015080; ENSSSCG00065026769
ENSSSCT00065036014; ENSSSCP00065015082; ENSSSCG00065026769
ENSSSCT00065036024; ENSSSCP00065015086; ENSSSCG00065026769

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100037961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100037961

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF095956 mRNA Translation: ABK96810.1
RefSeqiNP_001090927.1, NM_001097458.1
XP_005657322.2, XM_005657265.2
XP_005657323.1, XM_005657266.2
XP_005657324.1, XM_005657267.2
XP_013845747.1, XM_013990293.1

3D structure databases

SMRiA1E295
ModBaseiSearch...

Protein-protein interaction databases

IntActiA1E295, 2 interactors
STRINGi9823.ENSSSCP00000024395

Protein family/group databases

MEROPSiC01.060

Proteomic databases

PaxDbiA1E295
PeptideAtlasiA1E295
PRIDEiA1E295

Genome annotation databases

EnsembliENSSSCT00000049406; ENSSSCP00000046743; ENSSSCG00000023666
ENSSSCT00015003893; ENSSSCP00015001345; ENSSSCG00015002579
ENSSSCT00015003921; ENSSSCP00015001359; ENSSSCG00015002579
ENSSSCT00025035776; ENSSSCP00025014937; ENSSSCG00025026366
ENSSSCT00030004003; ENSSSCP00030001587; ENSSSCG00030002799
ENSSSCT00035095352; ENSSSCP00035040101; ENSSSCG00035070519
ENSSSCT00040104061; ENSSSCP00040047304; ENSSSCG00040075101
ENSSSCT00045032170; ENSSSCP00045022270; ENSSSCG00045018627
ENSSSCT00045032247; ENSSSCP00045022327; ENSSSCG00045018627
ENSSSCT00045032316; ENSSSCP00045022379; ENSSSCG00045018627
ENSSSCT00045032398; ENSSSCP00045022441; ENSSSCG00045018627
ENSSSCT00045032468; ENSSSCP00045022486; ENSSSCG00045018627
ENSSSCT00050073267; ENSSSCP00050031547; ENSSSCG00050053741
ENSSSCT00055000049; ENSSSCP00055000041; ENSSSCG00055000027
ENSSSCT00060041735; ENSSSCP00060017740; ENSSSCG00060030710
ENSSSCT00065036005; ENSSSCP00065015077; ENSSSCG00065026769
ENSSSCT00065036011; ENSSSCP00065015080; ENSSSCG00065026769
ENSSSCT00065036014; ENSSSCP00065015082; ENSSSCG00065026769
ENSSSCT00065036024; ENSSSCP00065015086; ENSSSCG00065026769
GeneIDi100037961
KEGGissc:100037961

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1508
VGNCiVGNC:87074, CTSB

Phylogenomic databases

eggNOGiKOG1543, Eukaryota
GeneTreeiENSGT00940000158680
HOGENOMiCLU_012184_3_3_1
InParanoidiA1E295
OrthoDBi865289at2759
TreeFamiTF314576

Enzyme and pathway databases

ReactomeiR-SSC-1442490, Collagen degradation
R-SSC-1679131, Trafficking and processing of endosomal TLR
R-SSC-2022090, Assembly of collagen fibrils and other multimeric structures
R-SSC-2132295, MHC class II antigen presentation
R-SSC-6798695, Neutrophil degranulation

Gene expression databases

BgeeiENSSSCG00000023666, Expressed in kidney and 49 other tissues
ExpressionAtlasiA1E295, baseline and differential
GenevisibleiA1E295, SS

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR025661, Pept_asp_AS
IPR000169, Pept_cys_AS
IPR025660, Pept_his_AS
IPR000668, Peptidase_C1A_C
IPR012599, Propeptide_C1A
PfamiView protein in Pfam
PF00112, Peptidase_C1, 1 hit
PF08127, Propeptide_C1, 1 hit
PRINTSiPR00705, PAPAIN
SMARTiView protein in SMART
SM00645, Pept_C1, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640, THIOL_PROTEASE_ASN, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit
PS00639, THIOL_PROTEASE_HIS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATB_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1E295
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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