Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 67 (07 Apr 2021)
Sequence version 1 (23 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Verruculogen prenyltransferase

Gene

ftmPT3

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the prenylation of verruculogen, the last step in the biosynthesis of fumitremorgin A alkaloid. Also active with fumitremorgin B and 12-alpha,13-alpha-dihydroxyfumitremorgin C.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.069 sec(-1).
  1. KM=61.5 µM for dimethylallyl diphosphate1 Publication
  2. KM=5.7 µM for verruculogen1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Alkaloid biosynthesis

    This protein is involved in Alkaloid biosynthesis.1 Publication
    View all proteins of this organism that are known to be involved in Alkaloid biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei89SubstrateBy similarity1
    Binding sitei102Dimethylallyl diphosphateBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei104Required for regioselectivityBy similarity1
    Binding sitei194Dimethylallyl diphosphateBy similarity1
    Binding sitei196Dimethylallyl diphosphateBy similarity1
    Binding sitei273Dimethylallyl diphosphateBy similarity1
    Binding sitei275Dimethylallyl diphosphateBy similarity1
    Binding sitei378Dimethylallyl diphosphateBy similarity1
    Binding sitei443Dimethylallyl diphosphateBy similarity1
    Binding sitei447Dimethylallyl diphosphateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionPrenyltransferase, Transferase
    Biological processAlkaloid metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-18772

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.5.1.107, 504

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Verruculogen prenyltransferase (EC:2.5.1.107)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ftmPT3
    ORF Names:NFIA_093400
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri331117 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006702 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

    Organism-specific databases

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    FungiDB:NFIA_093400

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004241171 – 453Verruculogen prenyltransferaseAdd BLAST453

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    36630.CADNFIAP00007252

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A1DJ20

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502RHNQ, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_037431_0_0_1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PYTTVYY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1531660at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd13929, PT-DMATS_CymD, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR033964, Aro_prenylTrfase
    IPR017795, Aro_prenylTrfase_DMATS
    IPR012148, DMATS-type_fun

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR40627, PTHR40627, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF11991, Trp_DMAT, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000509, Trp_DMAT, 1 hit

    Structure-Function Linkage Database

    More...
    SFLDi
    SFLDS00036, Aromatic_Prenyltransferase, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR03429, arom_pren_DMATS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A1DJ20-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTIHPQNHDL PTGSAMKATP FEALDLVFHF EDQAQRQWWK QAGPVLGQHL
    60 70 80 90 100
    LLANYDINKQ YQYLCFFGHH IIPILGPGPG SGYDYHPLEI SQNFQRSGST
    110 120 130 140 150
    IRLGFQPRAY SSCVSPQDPF GELSTEEAMA RLGQVTGVEL DLQPYHLLAS
    160 170 180 190 200
    HLNLTKKEEK EMLQPTCYNS LSPSFKTQGL LAVELPRTGS ITLKGYWFLS
    210 220 230 240 250
    AKSMVTKTPI SELSFQAFRN IDHGKDLLVP ALRPIEEYFA EMKMKPANPT
    260 270 280 290 300
    TPQTTEFATV ACDHVDMSRT RFKLYLYECL WKYDRLADIY TLGGRLKNAP
    310 320 330 340 350
    GIAEGLELLR EIWSILQIPE GYHFASLQNS LLRKSTNAES CGEASKPASE
    360 370 380 390 400
    EREFFDDQAL IFNFEIRPGE KWPQPKVYFP LAYLTDSKAA DAVVALFEKL
    410 420 430 440 450
    GWKEEARRYK DNLKTYYPRC DLDKTSGLQH VLSFSYRPKT GPYTTVYYWK

    IGA
    Length:453
    Mass (Da):51,628
    Last modified:January 23, 2007 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70B6F6A64265823C
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    DS027696 Genomic DNA Translation: EAW19377.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_001261274.1, XM_001261273.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    EAW19377; EAW19377; NFIA_093400

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4587832

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    nfi:NFIA_093400

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    DS027696 Genomic DNA Translation: EAW19377.1
    RefSeqiXP_001261274.1, XM_001261273.1

    3D structure databases

    SMRiA1DJ20
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00007252

    Genome annotation databases

    EnsemblFungiiEAW19377; EAW19377; NFIA_093400
    GeneIDi4587832
    KEGGinfi:NFIA_093400

    Organism-specific databases

    VEuPathDBiFungiDB:NFIA_093400

    Phylogenomic databases

    eggNOGiENOG502RHNQ, Eukaryota
    HOGENOMiCLU_037431_0_0_1
    OMAiPYTTVYY
    OrthoDBi1531660at2759

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18772
    BRENDAi2.5.1.107, 504

    Family and domain databases

    CDDicd13929, PT-DMATS_CymD, 1 hit
    InterProiView protein in InterPro
    IPR033964, Aro_prenylTrfase
    IPR017795, Aro_prenylTrfase_DMATS
    IPR012148, DMATS-type_fun
    PANTHERiPTHR40627, PTHR40627, 1 hit
    PfamiView protein in Pfam
    PF11991, Trp_DMAT, 1 hit
    PIRSFiPIRSF000509, Trp_DMAT, 1 hit
    SFLDiSFLDS00036, Aromatic_Prenyltransferase, 1 hit
    TIGRFAMsiTIGR03429, arom_pren_DMATS, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFTMT3_NEOFI
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1DJ20
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
    Last sequence update: January 23, 2007
    Last modified: April 7, 2021
    This is version 67 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again