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Entry version 86 (31 Jul 2019)
Sequence version 1 (23 Jan 2007)
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Protein
Submitted name:

ABC multidrug transporter, putative

Gene

NFIA_090380

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi893 – 900ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ABC multidrug transporter, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:NFIA_090380Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri331117 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006702 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:NFIA_090380

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei524 – 548HelicalSequence analysisAdd BLAST25
Transmembranei560 – 581HelicalSequence analysisAdd BLAST22
Transmembranei602 – 626HelicalSequence analysisAdd BLAST25
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Transmembranei670 – 689HelicalSequence analysisAdd BLAST20
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Transmembranei1225 – 1248HelicalSequence analysisAdd BLAST24
Transmembranei1269 – 1295HelicalSequence analysisAdd BLAST27
Transmembranei1315 – 1337HelicalSequence analysisAdd BLAST23
Transmembranei1349 – 1373HelicalSequence analysisAdd BLAST25
Transmembranei1465 – 1486HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 415ABC transporterInterPro annotationAdd BLAST250
Domaini857 – 1100ABC transporterInterPro annotationAdd BLAST244

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 64DisorderedSequence analysisAdd BLAST64
Regioni79 – 108DisorderedSequence analysisAdd BLAST30
Regioni822 – 842DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 29PolarSequence analysisAdd BLAST15
Compositional biasi30 – 64PolyampholyteSequence analysisAdd BLAST35
Compositional biasi79 – 103PolarSequence analysisAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162078

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDKYALY

Database of Orthologous Groups

More...
OrthoDBi
37708at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1DI73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMQLSYPAP FGAAAVSSSA SQEVASTVRR QFTDAEEDRI VETPLGEKAD
60 70 80 90 100
SSDTAEPDSE DGIDQEGHEK ITALARSLSQ ISQRSADPTN TFLNPSSDPE
110 120 130 140 150
LDPNSDKFSS RKWMKNLLHI KTRDPDRYPR RTAGVSFRNL NAYGYGTAAD
160 170 180 190 200
YQADVANMWL KGFGWLRSIL GCRNRVRIDI LRNFEGFVRS GEMLVVLGRP
210 220 230 240 250
GSGCSTFLKT IAGETHGLWL DEGTHIQYEG ISWDEMHSRF RGEVIYQAET
260 270 280 290 300
EIHFPQLTAG ETLLFAAQAR TPANRFPGVS REQHATHMRD VVMTMLGLSH
310 320 330 340 350
TMNTRIGNEY IRGVSGGERK RVSIAETILC GCPLQCWDNS TRGLDSSTAL
360 370 380 390 400
EFVKNLRLST DYTGSTAIVA IYQASQAIYD IFDKVIVLYE GRQIYFGKAS
410 420 430 440 450
DAKRFFIDMG FDCPDRQTTG DFLTSLTSPS ERLVRKGYEA LVPRTPDEFA
460 470 480 490 500
ARWRESAERQ RLLADIEAFE NESPLGGSKY KEFTVSRAAE KAKGTRAPSP
510 520 530 540 550
YTLSYPMQIR LCLRRGFLRL KGDMSMTLAT VIGNSIMAFI VSSVFYNLDQ
560 570 580 590 600
TTNSFFSRGA LLFFAILLNA FASSLEILTL WQQRPIVEKH DKYALYHPSA
610 620 630 640 650
EAISSMIVDL PSKFLVSIVF NLILYFMTNL RRTPGHFFVF YLFSVTITLT
660 670 680 690 700
MSNIFRWIGA ISRSMAQAMV PSSIFMMILV IYTGFTIPVR DMHPWFKWLN
710 720 730 740 750
YLNPIGYAFE SLMINEFSDR KFPCAQYVPA GPGYEDVPLS SKICSQKGAV
760 770 780 790 800
AGQDYVDGDA FINTSYRYFS SHLWRNYGII LGFFFFFLAA YIICSELVRA
810 820 830 840 850
KPSKGEILVF PRGKIPAFVK KPRRDGDLEG APTSEKQHLD NAGHDSTAAI
860 870 880 890 900
VKQTSIFHWQ DVCYDIKVKG ETRRILDHID GWVKPGTLTA LMGVTGAGKT
910 920 930 940 950
SLLDVLANRV TMGVITGEML VDGRMRDDSF QRKTGYVQQQ DLHLETSTVR
960 970 980 990 1000
EALIFSATLR QPASTPHKEK LAYVEEVIKM LNMEEYAEAV VGVLGEGLNV
1010 1020 1030 1040 1050
EQRKRLTIGV ELAAKPALLC FFDEPTSGLD SQTAWSICTL MRKLADHGQA
1060 1070 1080 1090 1100
ILCTIHQPSA ILMQQFDRLL FLAKGGKTVY FGELGPNMET LIKYFENKGS
1110 1120 1130 1140 1150
SNCPKNANPA EWMLEVIGAA PGSHADQDWP EVWNNSPERA QVRAELAQMK
1160 1170 1180 1190 1200
EELLQRPPPP RTKEYGEFAM PLWAQFLVCL QRMLQQYWRS PSYIYSKAAT
1210 1220 1230 1240 1250
CIIPPLFIGF TFWREPTSLQ GMQNQMFAIF MLLVIFPNLV QQMMPHFVTQ
1260 1270 1280 1290 1300
RALYEVRERP SKAYSWKAFM LASILVELPW NILMAVPAYF CWYYPIGLYR
1310 1320 1330 1340 1350
NAYPTDSVTE RGGTMFLLIL IFMMFTSTFS SMIIAGIEQP ETGGNIAQLL
1360 1370 1380 1390 1400
FSLCLIFNGV LASPSALPGF WIFMYRVSPF TYLVSSVLSV GLAGTSVKCS
1410 1420 1430 1440 1450
DIEILHVPPP QGQNCSSFLD EYVQMSHGRL LNPEATSNCQ VCPVADTDTF
1460 1470 1480 1490
LAQLNISFSD RWRNVGLLFV YIVFNIFAAV FLYWLIRVPK KRSRKIKEE
Length:1,499
Mass (Da):168,923
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CDECFB2A2F63BAC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS027696 Genomic DNA Translation: EAW19080.1

NCBI Reference Sequences

More...
RefSeqi
XP_001260977.1, XM_001260976.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAW19080; EAW19080; NFIA_090380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4587535

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nfi:NFIA_090380

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA Translation: EAW19080.1
RefSeqiXP_001260977.1, XM_001260976.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAW19080; EAW19080; NFIA_090380
GeneIDi4587535
KEGGinfi:NFIA_090380

Organism-specific databases

EuPathDBiFungiDB:NFIA_090380

Phylogenomic databases

HOGENOMiHOG000162078
OMAiHDKYALY
OrthoDBi37708at2759

Family and domain databases

CDDicd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1DI73_NEOFI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1DI73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: July 31, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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