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Entry version 71 (02 Dec 2020)
Sequence version 1 (23 Jan 2007)
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Protein

Mediator of RNA polymerase II transcription subunit 12

Gene

srb8

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 12
Alternative name(s):
Mediator complex subunit 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:srb8
Synonyms:med12
ORF Names:NFIA_071020
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri331117 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006702 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
FungiDB:NFIA_071020

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003129741 – 1612Mediator of RNA polymerase II transcription subunit 12Add BLAST1612

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the srb8-11 complex, which itself associates with the Mediator complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
36630.CADNFIAP00005560

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A1D887

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4522, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002034_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DNKREAW

Database of Orthologous Groups

More...
OrthoDBi
285540at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019035, Mediator_Med12

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09497, Med12, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01281, Med12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1D887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPHSSAGVQ SWGQPLHAVY SGTGRADLSQ PLGQPDRQPE QPSMPVPQLQ
60 70 80 90 100
GRPPALIDLT TNDGDVLERE PPAKRLKIDV HAGSVAGDGS PASAGVGESK
110 120 130 140 150
STPSATTSKP PSLSWRARPV WSFQALLSEV SGSAEINGES AAGVVQDVKP
160 170 180 190 200
PPPPSFPGPP WKFAPADTIA SDSAGAQDGA PSKEVQTTPY HIETPSVAPV
210 220 230 240 250
IRGEKVADFS PWMGNHPEDV LNEQTAKQGY YDRTQVSQNE SNTARPSLYA
260 270 280 290 300
QLKHRSGLQI LSSVFAAALE KRQGHNMVTA PSTFKPPPRV TLTDNKREAW
310 320 330 340 350
LRDLANPNVP LRKLSRTIPH GIRGRVLLDQ CLTKWVPVGR AVWLAKCVGA
360 370 380 390 400
NEIRAFKRKG TSGALAIGLE AKWVRDWTAN VQQFLEGVIT SCGVADWKMK
410 420 430 440 450
MTYAVSLTAR LFFEQLLDHD QYLGWFLTSL EAAPFNTLPV WLLMLGIYWS
460 470 480 490 500
NILRYRKRGR RLAELLLDKL QVAIKSDSAT SLRPLTDRLS LHIRKLTLEH
510 520 530 540 550
TSSMVLPQSW EKYKDLLSSC LDLNDNVHRA VFQNLAERNA RVQRPRKCEE
560 570 580 590 600
TTQQPPQQRV IQLFDSIGSS NDITSVSAAS LGAIDDKAAL VLKLLEWAAT
610 620 630 640 650
PFRYGVSRVY TGARLLRKWK IAGVDVDTSI ISFLGESQMR DQLNMDNIYH
660 670 680 690 700
IVSELVRSQT FSVGKYLQWL MAKGVADFPQ NSDHQPLSGD LALLMQLPVS
710 720 730 740 750
RLPEHVHNLR NTLLHRAGVE VSKESSTIAI LKASIAERLP RIFGSVATSA
760 770 780 790 800
VSRDPLPSDL TWAVKSELGQ WIRRGVTEFG RDPRRAFQDL HSAPSAEHFA
810 820 830 840 850
LTPGEFYTVR DILESFGDLS ILADVLKQAT VCNDGIVLAS AADTVNYHFR
860 870 880 890 900
SFCVIGATTD LFKRLVESYA RLKRLGSTSL DLIFSLIDLG LRLPGELNTV
910 920 930 940 950
ALLRQDLSRI ESKSSMAAPS PLSDHIPSSF NETDPLFLLK LDQLLSSASG
960 970 980 990 1000
IDESTLDTIF NLLIKQIESS GGHAKLSVNE TCRYLSYLRP FHPKRFDIMI
1010 1020 1030 1040 1050
VRWICGLLRS TTGGILSQVL PPLIGVGCVT IQAFVFLVRR LLKSENMMSN
1060 1070 1080 1090 1100
QRDLRIDLLQ LLVPPPAGQS RYFDMVTYRF HLSRKEFLFK HPEEVFDIIR
1110 1120 1130 1140 1150
DAIALIDSQS QEGNYRQVDL GHSAMVLLQI LLTKNPESAV KHCTEKLIGQ
1160 1170 1180 1190 1200
HPSAVTVLTR ALDSLLGLDT KAGERLFTSN GSFIFITIDT GPAAPDISVA
1210 1220 1230 1240 1250
EKVIELTNDF SLPFCRLKLQ LLFNAETKGD VRNEIVDVMF KAAVADSRSR
1260 1270 1280 1290 1300
RSNWVGLVRL MSHDAVRQIR ERAEKNFFAI PLFEESPDGC SSFAADNSSS
1310 1320 1330 1340 1350
LETAKLYLAI IEKLAYSIPD VGPQAVVPVL TEKMDLLLQR LITMQANYSG
1360 1370 1380 1390 1400
TTELSHGVDA EHMIRSRTQF ERALAFWFSA LLRMIVLHRT AFSVPSAAVR
1410 1420 1430 1440 1450
PSALPEQTRL LISIFCITLA RLPDSVLRLF PAADYFPHSM TAGDCRPCPG
1460 1470 1480 1490 1500
ILLQTHALDV AASLIDTFPD EARHQCARYL REKCPPFARV QNDSRFLYLL
1510 1520 1530 1540 1550
GPLGDSPSSN ITLPVSIPSP AASGSTPAPT PSGNPTGGFS HPQQPAFVSG
1560 1570 1580 1590 1600
VPTGLPDGLN CAASHLCLQY RGRAIGAYPV RPWELLEDAA PIAGTNDTAV
1610
SLGYFDARRV RV
Length:1,612
Mass (Da):177,653
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59802224655CD774
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS027690 Genomic DNA Translation: EAW21931.1

NCBI Reference Sequences

More...
RefSeqi
XP_001263828.1, XM_001263827.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAW21931; EAW21931; NFIA_071020

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4590474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nfi:NFIA_071020

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027690 Genomic DNA Translation: EAW21931.1
RefSeqiXP_001263828.1, XM_001263827.1

3D structure databases

SMRiA1D887
ModBaseiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00005560

Genome annotation databases

EnsemblFungiiEAW21931; EAW21931; NFIA_071020
GeneIDi4590474
KEGGinfi:NFIA_071020

Organism-specific databases

EuPathDBiFungiDB:NFIA_071020

Phylogenomic databases

eggNOGiKOG4522, Eukaryota
HOGENOMiCLU_002034_1_0_1
OMAiDNKREAW
OrthoDBi285540at2759

Family and domain databases

InterProiView protein in InterPro
IPR019035, Mediator_Med12
PfamiView protein in Pfam
PF09497, Med12, 1 hit
SMARTiView protein in SMART
SM01281, Med12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRB8_NEOFI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1D887
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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