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UniProtKB - A1D510 (A1D510_NEOFI)

Entry version 81 (16 Oct 2019)
Sequence version 1 (23 Jan 2007)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

NFIA_022140

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:NFIA_022140Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri331117 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006702 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:NFIA_022140

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotationImported

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...    STRINGi    		36630.CADNFIAP00000595

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 476RNA_pol_Rpb2_1InterPro annotationAdd BLAST386
    Domaini245 – 424RNA_pol_Rpb2_2InterPro annotationAdd BLAST180
    Domaini503 – 566RNA_pol_Rpb2_3InterPro annotationAdd BLAST64
    Domaini605 – 664RNA_pol_Rpb2_4InterPro annotationAdd BLAST60
    Domaini685 – 725RNA_pol_Rpb2_5InterPro annotationAdd BLAST41
    Domaini732 – 1103RNA_pol_Rpb2_6InterPro annotationAdd BLAST372
    Domaini1105 – 1189RNA_pol_Rpb2_7InterPro annotationAdd BLAST85

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 53DisorderedSequence analysisAdd BLAST53

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 28PolarSequence analysisAdd BLAST17
    Compositional biasi34 – 50PolyampholyteSequence analysisAdd BLAST17

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the RNA polymerase beta chain family.UniRule annotation

    Phylogenomic databases

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000222962

    KEGG Orthology (KO)

    More...    KOi    		K03021

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		RFNWELK

    Database of Orthologous Groups

    More...    OrthoDBi    		42570at2759

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd00653 RNA_pol_B_RPB2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR015712 DNA-dir_RNA_pol_su2
    IPR007120 DNA-dir_RNAP_su2_dom
    IPR037033 DNA-dir_RNAP_su2_hyb_sf
    IPR007121 RNA_pol_bsu_CS
    IPR007644 RNA_pol_bsu_protrusion
    IPR007642 RNA_pol_Rpb2_2
    IPR037034 RNA_pol_Rpb2_2_sf
    IPR007645 RNA_pol_Rpb2_3
    IPR007646 RNA_pol_Rpb2_4
    IPR007647 RNA_pol_Rpb2_5
    IPR007641 RNA_pol_Rpb2_7
    IPR014724 RNA_pol_RPB2_OB-fold

    The PANTHER Classification System

    More...    PANTHERi    		PTHR20856 PTHR20856, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF04563 RNA_pol_Rpb2_1, 1 hit
    PF04561 RNA_pol_Rpb2_2, 1 hit
    PF04565 RNA_pol_Rpb2_3, 1 hit
    PF04566 RNA_pol_Rpb2_4, 1 hit
    PF04567 RNA_pol_Rpb2_5, 1 hit
    PF00562 RNA_pol_Rpb2_6, 1 hit
    PF04560 RNA_pol_Rpb2_7, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS01166 RNA_POL_BETA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A1D510-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPPRRRPQPA AASQARSAQP SESKLPTNPA PAAENVEKDD RADEPSGPTY 
            60         70         80         90        100
    RYRDPFDALL EPFYYNKSLT DPINTAKDKW NLLPAFLKVK GLVKQHIDSY 
           110        120        130        140        150
    NYFIEVQLKK IVESSSTIRS DIDHTFYIKF TDIYVGSPCR ADEPQDVTPD 
           160        170        180        190        200
    ATPSDVSPHE CRLRDTTYAA PILVNFEYIR GRQRVTRKGV SIGRMPIMLR 
           210        220        230        240        250
    SSKCVLANKT PSEMTVLNEC PLDPGGYFIV NGTEKVILVQ EQLSKNRIIV 
           260        270        280        290        300
    ETDPKKEIVQ ASVTSSSNER KSKSYIILKK DKLYVKHNVL SEDIPIVILL 
           310        320        330        340        350
    RAMGIHTEQE MLLLVAGVDS LYQDDFAINF EESIKLGIYT QQQALDWIGA 
           360        370        380        390        400
    RIKINRKQSS YRRTHIQEAV EAIASVIISH IEVKNMNFRP KAVYVAHMAR 
           410        420        430        440        450
    RVLMAKNDPS LVDDRDYLGN KRLELAGQLL ALLFEDLFKK FCFDIKMNID 
           460        470        480        490        500
    KVLNKRNRAE QFDAWTVMSM HSNHITQGMN RAISTGNWSL KRFRMERAGV 
           510        520        530        540        550
    THVLSRLSYI AALGMMTRIS SQFEKTRKVS GPRALQPSQF GMLCPADTPE 
           560        570        580        590        600
    GEACGLVKNL ALMTHITTND EEGPIKNLVF MLGAEDIMAL GGKQLYTPGS 
           610        620        630        640        650
    YTISINGTPI ALTRRPKYFL NAFRRLRRMG RISEFVSIYI NHHQCAVHIA 
           660        670        680        690        700
    TDDGRICRPL IVVENGRSLV TARHLDKLRD GTMQFDDFLA QGLVEYLDVN 
           710        720        730        740        750
    EENDSLIALY EKDITDTTTH LEIEPFTVLG AVAGLIPYPH HNQSPRNTYQ 
           760        770        780        790        800
    CAMGKQAIGA IASNQFLRID SILYLMVYPQ KPMVKSRTIE LVKYDQLPAG 
           810        820        830        840        850
    QNAMVAVMSY SGYDIEDALV LNKGSVDRGF GRCQVFRKYV TNLKSYSNGT 
           860        870        880        890        900
    KDRLNPPTYE NGAPIRKHAL LEADGLAAVG EQVNAGEVYI NKSTPEQSNL 
           910        920        930        940        950
    SGIGSDAGRP VQYTPTPMTY KLHDPAYIDK VMYSVQENEN QLVKVLVRQT 
           960        970        980        990       1000
    RRPEVGDKFS SRHGQKGVVG IIADQADMPF TDAGINPDII MNPHGFPSRM 
          1010       1020       1030       1040       1050
    TVGKMLELVA GKAGVLAGHH GYGTCFGGTP VEEASRILID HGFSYGGKDY 
          1060       1070       1080       1090       1100
    LTSGITGEAL PFYVFTGPIY YQKLKHMVQD KMHSRARGPR AILTRQPTEG 
          1110       1120       1130       1140       1150
    RSRDGGLRLG EMERDCLIAY GTSQLLLERL MISSDRHEID VCEQCGFMGY 
          1160       1170       1180       1190       1200
    LNWCQRCKSS RSVVKMTIPY AAKLLIQELM SMNVTARLKL DDEFPEWKGT
    Length:1,200
    Mass (Da):134,785
    Last modified:January 23, 2007 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i943BE3D44461D738
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		DS027688 Genomic DNA Translation: EAW23503.1

    NCBI Reference Sequences

    More...    RefSeqi    		XP_001265400.1, XM_001265399.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...    EnsemblFungii    		EAW23503; EAW23503; NFIA_022140

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		4590753

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		nfi:NFIA_022140

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		DS027688 Genomic DNA Translation: EAW23503.1
    RefSeqiXP_001265400.1, XM_001265399.1

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00000595

    Genome annotation databases

    EnsemblFungiiEAW23503; EAW23503; NFIA_022140
    GeneIDi4590753
    KEGGinfi:NFIA_022140

    Organism-specific databases

    EuPathDBiFungiDB:NFIA_022140

    Phylogenomic databases

    HOGENOMiHOG000222962
    KOiK03021
    OMAiRFNWELK
    OrthoDBi42570at2759

    Family and domain databases

    CDDicd00653 RNA_pol_B_RPB2, 1 hit
    Gene3Di2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit
    InterProiView protein in InterPro
    IPR015712 DNA-dir_RNA_pol_su2
    IPR007120 DNA-dir_RNAP_su2_dom
    IPR037033 DNA-dir_RNAP_su2_hyb_sf
    IPR007121 RNA_pol_bsu_CS
    IPR007644 RNA_pol_bsu_protrusion
    IPR007642 RNA_pol_Rpb2_2
    IPR037034 RNA_pol_Rpb2_2_sf
    IPR007645 RNA_pol_Rpb2_3
    IPR007646 RNA_pol_Rpb2_4
    IPR007647 RNA_pol_Rpb2_5
    IPR007641 RNA_pol_Rpb2_7
    IPR014724 RNA_pol_RPB2_OB-fold
    PANTHERiPTHR20856 PTHR20856, 1 hit
    PfamiView protein in Pfam
    PF04563 RNA_pol_Rpb2_1, 1 hit
    PF04561 RNA_pol_Rpb2_2, 1 hit
    PF04565 RNA_pol_Rpb2_3, 1 hit
    PF04566 RNA_pol_Rpb2_4, 1 hit
    PF04567 RNA_pol_Rpb2_5, 1 hit
    PF00562 RNA_pol_Rpb2_6, 1 hit
    PF04560 RNA_pol_Rpb2_7, 1 hit
    PROSITEiView protein in PROSITE
    PS01166 RNA_POL_BETA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1D510_NEOFI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1D510
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 16, 2019
    This is version 81 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported
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