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Entry version 81 (16 Oct 2019)
Sequence version 1 (23 Jan 2007)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

NFIA_022140

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:NFIA_022140Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri331117 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006702 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:NFIA_022140

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotationImported

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    36630.CADNFIAP00000595

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 476RNA_pol_Rpb2_1InterPro annotationAdd BLAST386
    Domaini245 – 424RNA_pol_Rpb2_2InterPro annotationAdd BLAST180
    Domaini503 – 566RNA_pol_Rpb2_3InterPro annotationAdd BLAST64
    Domaini605 – 664RNA_pol_Rpb2_4InterPro annotationAdd BLAST60
    Domaini685 – 725RNA_pol_Rpb2_5InterPro annotationAdd BLAST41
    Domaini732 – 1103RNA_pol_Rpb2_6InterPro annotationAdd BLAST372
    Domaini1105 – 1189RNA_pol_Rpb2_7InterPro annotationAdd BLAST85

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 53DisorderedSequence analysisAdd BLAST53

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 28PolarSequence analysisAdd BLAST17
    Compositional biasi34 – 50PolyampholyteSequence analysisAdd BLAST17

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the RNA polymerase beta chain family.UniRule annotation

    Phylogenomic databases

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000222962

    KEGG Orthology (KO)

    More...
    KOi
    K03021

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    RFNWELK

    Database of Orthologous Groups

    More...
    OrthoDBi
    42570at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00653 RNA_pol_B_RPB2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR015712 DNA-dir_RNA_pol_su2
    IPR007120 DNA-dir_RNAP_su2_dom
    IPR037033 DNA-dir_RNAP_su2_hyb_sf
    IPR007121 RNA_pol_bsu_CS
    IPR007644 RNA_pol_bsu_protrusion
    IPR007642 RNA_pol_Rpb2_2
    IPR037034 RNA_pol_Rpb2_2_sf
    IPR007645 RNA_pol_Rpb2_3
    IPR007646 RNA_pol_Rpb2_4
    IPR007647 RNA_pol_Rpb2_5
    IPR007641 RNA_pol_Rpb2_7
    IPR014724 RNA_pol_RPB2_OB-fold

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR20856 PTHR20856, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04563 RNA_pol_Rpb2_1, 1 hit
    PF04561 RNA_pol_Rpb2_2, 1 hit
    PF04565 RNA_pol_Rpb2_3, 1 hit
    PF04566 RNA_pol_Rpb2_4, 1 hit
    PF04567 RNA_pol_Rpb2_5, 1 hit
    PF00562 RNA_pol_Rpb2_6, 1 hit
    PF04560 RNA_pol_Rpb2_7, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01166 RNA_POL_BETA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A1D510-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPPRRRPQPA AASQARSAQP SESKLPTNPA PAAENVEKDD RADEPSGPTY
    60 70 80 90 100
    RYRDPFDALL EPFYYNKSLT DPINTAKDKW NLLPAFLKVK GLVKQHIDSY
    110 120 130 140 150
    NYFIEVQLKK IVESSSTIRS DIDHTFYIKF TDIYVGSPCR ADEPQDVTPD
    160 170 180 190 200
    ATPSDVSPHE CRLRDTTYAA PILVNFEYIR GRQRVTRKGV SIGRMPIMLR
    210 220 230 240 250
    SSKCVLANKT PSEMTVLNEC PLDPGGYFIV NGTEKVILVQ EQLSKNRIIV
    260 270 280 290 300
    ETDPKKEIVQ ASVTSSSNER KSKSYIILKK DKLYVKHNVL SEDIPIVILL
    310 320 330 340 350
    RAMGIHTEQE MLLLVAGVDS LYQDDFAINF EESIKLGIYT QQQALDWIGA
    360 370 380 390 400
    RIKINRKQSS YRRTHIQEAV EAIASVIISH IEVKNMNFRP KAVYVAHMAR
    410 420 430 440 450
    RVLMAKNDPS LVDDRDYLGN KRLELAGQLL ALLFEDLFKK FCFDIKMNID
    460 470 480 490 500
    KVLNKRNRAE QFDAWTVMSM HSNHITQGMN RAISTGNWSL KRFRMERAGV
    510 520 530 540 550
    THVLSRLSYI AALGMMTRIS SQFEKTRKVS GPRALQPSQF GMLCPADTPE
    560 570 580 590 600
    GEACGLVKNL ALMTHITTND EEGPIKNLVF MLGAEDIMAL GGKQLYTPGS
    610 620 630 640 650
    YTISINGTPI ALTRRPKYFL NAFRRLRRMG RISEFVSIYI NHHQCAVHIA
    660 670 680 690 700
    TDDGRICRPL IVVENGRSLV TARHLDKLRD GTMQFDDFLA QGLVEYLDVN
    710 720 730 740 750
    EENDSLIALY EKDITDTTTH LEIEPFTVLG AVAGLIPYPH HNQSPRNTYQ
    760 770 780 790 800
    CAMGKQAIGA IASNQFLRID SILYLMVYPQ KPMVKSRTIE LVKYDQLPAG
    810 820 830 840 850
    QNAMVAVMSY SGYDIEDALV LNKGSVDRGF GRCQVFRKYV TNLKSYSNGT
    860 870 880 890 900
    KDRLNPPTYE NGAPIRKHAL LEADGLAAVG EQVNAGEVYI NKSTPEQSNL
    910 920 930 940 950
    SGIGSDAGRP VQYTPTPMTY KLHDPAYIDK VMYSVQENEN QLVKVLVRQT
    960 970 980 990 1000
    RRPEVGDKFS SRHGQKGVVG IIADQADMPF TDAGINPDII MNPHGFPSRM
    1010 1020 1030 1040 1050
    TVGKMLELVA GKAGVLAGHH GYGTCFGGTP VEEASRILID HGFSYGGKDY
    1060 1070 1080 1090 1100
    LTSGITGEAL PFYVFTGPIY YQKLKHMVQD KMHSRARGPR AILTRQPTEG
    1110 1120 1130 1140 1150
    RSRDGGLRLG EMERDCLIAY GTSQLLLERL MISSDRHEID VCEQCGFMGY
    1160 1170 1180 1190 1200
    LNWCQRCKSS RSVVKMTIPY AAKLLIQELM SMNVTARLKL DDEFPEWKGT
    Length:1,200
    Mass (Da):134,785
    Last modified:January 23, 2007 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i943BE3D44461D738
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    DS027688 Genomic DNA Translation: EAW23503.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_001265400.1, XM_001265399.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    EAW23503; EAW23503; NFIA_022140

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4590753

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    nfi:NFIA_022140

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    DS027688 Genomic DNA Translation: EAW23503.1
    RefSeqiXP_001265400.1, XM_001265399.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00000595

    Genome annotation databases

    EnsemblFungiiEAW23503; EAW23503; NFIA_022140
    GeneIDi4590753
    KEGGinfi:NFIA_022140

    Organism-specific databases

    EuPathDBiFungiDB:NFIA_022140

    Phylogenomic databases

    HOGENOMiHOG000222962
    KOiK03021
    OMAiRFNWELK
    OrthoDBi42570at2759

    Family and domain databases

    CDDicd00653 RNA_pol_B_RPB2, 1 hit
    Gene3Di2.40.270.10, 1 hit
    2.40.50.150, 1 hit
    3.90.1110.10, 1 hit
    InterProiView protein in InterPro
    IPR015712 DNA-dir_RNA_pol_su2
    IPR007120 DNA-dir_RNAP_su2_dom
    IPR037033 DNA-dir_RNAP_su2_hyb_sf
    IPR007121 RNA_pol_bsu_CS
    IPR007644 RNA_pol_bsu_protrusion
    IPR007642 RNA_pol_Rpb2_2
    IPR037034 RNA_pol_Rpb2_2_sf
    IPR007645 RNA_pol_Rpb2_3
    IPR007646 RNA_pol_Rpb2_4
    IPR007647 RNA_pol_Rpb2_5
    IPR007641 RNA_pol_Rpb2_7
    IPR014724 RNA_pol_RPB2_OB-fold
    PANTHERiPTHR20856 PTHR20856, 1 hit
    PfamiView protein in Pfam
    PF04563 RNA_pol_Rpb2_1, 1 hit
    PF04561 RNA_pol_Rpb2_2, 1 hit
    PF04565 RNA_pol_Rpb2_3, 1 hit
    PF04566 RNA_pol_Rpb2_4, 1 hit
    PF04567 RNA_pol_Rpb2_5, 1 hit
    PF00562 RNA_pol_Rpb2_6, 1 hit
    PF04560 RNA_pol_Rpb2_7, 1 hit
    PROSITEiView protein in PROSITE
    PS01166 RNA_POL_BETA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1D510_NEOFI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1D510
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 16, 2019
    This is version 81 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported
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