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Protein

5'-3' exoribonuclease 1

Gene

NFIA_038990

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseUniRule annotationImported, Hydrolase, Nuclease, RNA-bindingUniRule annotation
Biological processNonsense-mediated mRNA decayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
5'-3' exoribonuclease 1UniRule annotation (EC:3.1.13.-UniRule annotation)
Gene namesi
ORF Names:NFIA_038990Imported
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)Imported
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_038990

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00003812

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 227XRN_NInterPro annotationAdd BLAST227

Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000160331
KOiK12618
OMAiWVLMGFM
OrthoDBiEOG092C068M

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

Sequencei

Sequence statusi: Complete.

A1D003-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVPKFFRWL SERYPTISML IAENRIPEFD ALYLDMNGII HNCTHKDSDS
60 70 80 90 100
PTFRMTEDKM FIAIFNYIEH LYGKIKPRKL FFMAVDGVAP RAKMNQQRAR
110 120 130 140 150
RFRTALDAEV AKEKAIAQGI EMPKEDPFDS NCITPGTEFM AKLTQQLKYF
160 170 180 190 200
INKKISEDKD WQGVDIVLSG HEVPGEGEHK IMEYIRHAKA QPGYDPNIRH
210 220 230 240 250
CLYGLDADLI MLGLLSHDPH FCLLREEVTF GRQVQKKPKE LEHQNFYLLH
260 270 280 290 300
LCMVREYLEL EFQELEQEGV LDFPFDMERV IDDFILMAFF VGNDFLPNLP
310 320 330 340 350
NLHINEGALS LMFKIYKDVL PKMGGYVNEG GVINLKRLGM LIEALSDVEF
360 370 380 390 400
RFFEAEYSDA RWINAKRNGV ENGSEFQEKP KGLTLTPAQK ELFKEIKKYV
410 420 430 440 450
LNRPEKASGS KPLDLSPTLP ARDRKFVEQL ADDLRLPWTT VADEHGDRFI
460 470 480 490 500
RLQLPANEDD DSEEEEDEEA SMAVQRVIRR YDNAKVQEIS PEEAQKAAEK
510 520 530 540 550
KYEEKFQDWK DKYYMSKFGW GLDNHEEMRK LTENYVQGLQ WVLYYYYRGI
560 570 580 590 600
ASWPWFFKYH YAPMISDVIK GLNADMNFKL GQPFKPYEQL MGVLPDRSKQ
610 620 630 640 650
IVPAAFRDLM TSPESPIIDF YPRDFELDMN GKKMEWEAVV KIPFIDERRL
660 670 680 690 700
LEALATREHL LTPEEKARNG FGVSLKFTYS PEVNFTYPSS LPGVFPDLPS
710 720 730 740 750
CHCIENIFDL PTMDGLEPYI GLVEGVQLGA AALAGFPSLK TLPHVGQLGF
760 770 780 790 800
HGVCVFQQES RNESMVITVL DPGSRSNIEL AKQKLGKRVF VGYPFLQEAL
810 820 830 840 850
VIRVSDELFD YLLPEGENHV VSIPHTEAQI DQWKKKADKI EGMYSRRLGT
860 870 880 890 900
IIGPVESMVH VQLLKGLIKT DEGATIKEFA DIPGQETDYA LQLVVDEVIN
910 920 930 940 950
PDERFIERDA LPIEKEFPEG SRAFFLGDFN YGRPVHITGH ENGKVNGLIA
960 970 980 990 1000
AIKGREPEFG KDRAREAERL CPYMPSFAIA RSLRLNPLVL AKITSSFSVD
1010 1020 1030 1040 1050
MEGQRVNLGL NLKFEARKQK VLGYSRRGES GWEFSPKAVD LLQQYMIKFP
1060 1070 1080 1090 1100
EFIAGIQRNP QKDRYQPTDF YPEDVALVKM KEIRDWLKAM EAKNFERVPL
1110 1120 1130 1140 1150
EAEQLDSDVV KLIEQDADQL VQSQPPMQPK KIRGVPRSAL LRPSDVEQRL
1160 1170 1180 1190 1200
QNQTFKLGDR VVYAQDSGKV PIATRGTVVG LTRTPRAMLL DVVFDVSFMS
1210 1220 1230 1240 1250
GTTLGDRCSP FRGQTVLASS VLNVSYRQLL ASTRAAASQQ AQSQPSPLTV
1260 1270 1280 1290 1300
AGYGAPLGPN GLGQLKEAAA PPPLTNSYRG AVSGLGNTRG NGAPHRGRGG
1310 1320 1330 1340 1350
RGAANGGSPH TTLPFRPHPS NGDGTEQRGG RGRGGMYRTR AGYVSVDNSN
1360 1370 1380 1390 1400
PEAGVVRNNP HFRPQNYSQV PPPKALNRGG GRGGRGGFRG SDRGSGSRGR
1410
GGHRGRGAAI ISTE
Length:1,414
Mass (Da):159,653
Last modified:January 23, 2007 - v1
Checksum:iACE9F5392DCF5775
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027686 Genomic DNA Translation: EAW24323.1
RefSeqiXP_001266220.1, XM_001266219.1

Genome annotation databases

EnsemblFungiiEAW24323; EAW24323; NFIA_038990
GeneIDi4592879
KEGGinfi:NFIA_038990

Similar proteinsi

Entry informationi

Entry nameiA1D003_NEOFI
AccessioniPrimary (citable) accession number: A1D003
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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