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UniProtKB - A1CSW0 (A1CSW0_ASPCL)

Entry version 61 (16 Oct 2019)
Sequence version 1 (23 Jan 2007)
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Protein
Submitted name:

Thiamine biosynthetic bifunctional enzyme, putative

Gene

ACLA_080810

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Thiamine biosynthetic bifunctional enzyme, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ACLA_080810Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri344612 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006701 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:ACLA_080810

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		5057.CADACLAP00007678

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 201TMP-TENIInterPro annotationAdd BLAST195

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000214306

KEGG Orthology (KO)

More...KOi		K14154

Identification of Orthologs from Complete Genome Data

More...OMAi		PIMANYA

Database of Orthologous Groups

More...OrthoDBi		621894at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd01170 THZ_kinase, 1 hit
cd00564 TMP_TenI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.70, 1 hit
3.40.1190.20, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00228 Thz_kinase, 1 hit
MF_00097 TMP_synthase, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013785 Aldolase_TIM
IPR000417 Hyethyz_kinase
IPR029056 Ribokinase-like
IPR036206 ThiamineP_synth_sf
IPR022998 ThiamineP_synth_TenI
IPR034291 TMP_synthase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02110 HK, 1 hit
PF02581 TMP-TENI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01099 HYETHTZKNASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51391 SSF51391, 1 hit
SSF53613 SSF53613, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00693 thiE, 1 hit
TIGR00694 thiM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1CSW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLDLSVYLV TDSTPAILKG QDLCTVVEEA LKGGVTLVQY RDKKSDTGDL 
        60         70         80         90        100
IKTAKALHKI TQAYGVPLLI NDRVDVALAV GAEGVHLGQD DMYIAEAKQL 
       110        120        130        140        150
LPKDAIIGIT ASSIEEAQKA IEAGADYLGI GTMFATSTKT NTKNILGTAG 
       160        170        180        190        200
TQTILEAISD SGRNVGTVAI GGISLSNVQR VLYQAKAPRK GLDGVAIVSA 
       210        220        230        240        250
IVGADDPRAA AEEFVKRVNT PPTFAWEPKA PRANETSALL EEVPQIVQKM 
       260        270        280        290        300
VKAHPLVHNM INYVVANFVA NIALSMGASP IMSPYGEEAA DLAKFDGALV 
       310        320        330        340        350
INMGTLNSES VPNYLKAIKS YNERGNPVIY DPVGAAATHI RRGAVNELMR 
       360        370        380        390        400
GGYFDLIKGN EGEIKQVSGT SNTVQRGVDS GPSSLDGREK ATLARDLARR 
       410        420        430        440        450
ERNVVLLTGA VDYLSDGERV IAVENGHEYL GQVTGTGCAV GMVSGCFLAT 
       460        470        480        490        500
HRSDKLLAVL AGILMYEIAA ENAASKDYVR GPGSFVPAFL DELYAIRQAA 
       510 
LKGDDSWFVG RAKIQEIRL
Length:519
Mass (Da):55,142
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE37E2ECA43ECFC02
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DS027060 Genomic DNA Translation: EAW06397.1

NCBI Reference Sequences

More...RefSeqi		XP_001267823.1, XM_001267822.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		EAW06397; EAW06397; ACLA_080810

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4700142

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		act:ACLA_080810

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027060 Genomic DNA Translation: EAW06397.1
RefSeqiXP_001267823.1, XM_001267822.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi5057.CADACLAP00007678

Genome annotation databases

EnsemblFungiiEAW06397; EAW06397; ACLA_080810
GeneIDi4700142
KEGGiact:ACLA_080810

Organism-specific databases

EuPathDBiFungiDB:ACLA_080810

Phylogenomic databases

HOGENOMiHOG000214306
KOiK14154
OMAiPIMANYA
OrthoDBi621894at2759

Family and domain databases

CDDicd01170 THZ_kinase, 1 hit
cd00564 TMP_TenI, 1 hit
Gene3Di3.20.20.70, 1 hit
3.40.1190.20, 1 hit
HAMAPiMF_00228 Thz_kinase, 1 hit
MF_00097 TMP_synthase, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000417 Hyethyz_kinase
IPR029056 Ribokinase-like
IPR036206 ThiamineP_synth_sf
IPR022998 ThiamineP_synth_TenI
IPR034291 TMP_synthase
PfamiView protein in Pfam
PF02110 HK, 1 hit
PF02581 TMP-TENI, 1 hit
PRINTSiPR01099 HYETHTZKNASE
SUPFAMiSSF51391 SSF51391, 1 hit
SSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00693 thiE, 1 hit
TIGR00694 thiM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1CSW0_ASPCL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1CSW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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