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Entry version 73 (10 Feb 2021)
Sequence version 1 (23 Jan 2007)
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Protein

Protein transport protein sec23

Gene

sec23

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63ZincBy similarity1
Metal bindingi67ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi89ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein sec23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sec23
ORF Names:ACLA_031210
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri344612 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006701 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:ACLA_031210

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002954501 – 762Protein transport protein sec23Add BLAST762

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1CRW7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5057.CADACLAP00002848

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1CRW7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1986, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008658_3_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPPHYAE

Database of Orthologous Groups

More...
OrthoDBi
270617at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11287, Sec23_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR037364, Sec23
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR037550, Sec23_C
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11141, PTHR11141, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1CRW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYEALKDQW SDVEERDGIR LSWNTFPSTR MEASRLVVPI AAVYTPLKEK
60 70 80 90 100
PESPLLQYEP VTCKAPCRAV LNPYANVDVR ARIWICPFCL MRNPLPPHYK
110 120 130 140 150
DITENAIPPE LHPQSTTIEY QLARPAPAPP IFVYVVDTCQ EEDSLKALKD
160 170 180 190 200
TLILSLSLLP PNALVGLITF GTMAQVHELG YTECAKSYVF RGSKDYAAKQ
210 220 230 240 250
VQEMLGLLAP GPRPNVPQQP ARPPVGPAAR FLLPVQQAEF QITNVLEQLQ
260 270 280 290 300
RDPWPVANDK RPLRCTGVAL SVAVGLLETS FQNAGGRVMV FTSGPATEGP
310 320 330 340 350
GHVVGPELKE PIRSHHDIDR DNIKYYKKAV KFYDALAKRA ANNGHVVDIF
360 370 380 390 400
AGCLDQVGLL EMKNLSNFTG GHMLLTDSFT SSQFKQSFVR VFDKDANDNL
410 420 430 440 450
LMGFNASLEV LTTKELKVTG LIGHAVSLNK KSSSVGETEC GIGNTCAWKM
460 470 480 490 500
CGIDPASSYG VYFEIANQGG PAAVQPGPQR GMMQFLTYYQ HSSGHYHLRV
510 520 530 540 550
TTVARPLSGP TGDPALAQSF DQEAAAVLMA RIAVYKADVD DGPDVIRWVD
560 570 580 590 600
RMLIRLCSRF ADYRKDDPTS FRLEKNFTLY PQFMFHLRRS QFLQVFNNSP
610 620 630 640 650
DETAFYRHVL NHEDVGDSLV MIQPTLDSYS LEHEGSQPVL LDSASIQPTH
660 670 680 690 700
ILLLDTFFHI LIFHGETIAE WRKAGYQDQE GYENLKALLE QPKEDARELI
710 720 730 740 750
ADRFPLPRFI VCDAGGSQAR FLLSKLNPST THTTGGYGGG VTSQTIFTDD
760
VSLQTFMDHL MK
Length:762
Mass (Da):84,789
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE79DF9F5806BA0C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS027059 Genomic DNA Translation: EAW08388.1

NCBI Reference Sequences

More...
RefSeqi
XP_001269814.1, XM_001269813.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAW08388; EAW08388; ACLA_031210

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4700609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
act:ACLA_031210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027059 Genomic DNA Translation: EAW08388.1
RefSeqiXP_001269814.1, XM_001269813.1

3D structure databases

SMRiA1CRW7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00002848

Proteomic databases

PRIDEiA1CRW7

Genome annotation databases

EnsemblFungiiEAW08388; EAW08388; ACLA_031210
GeneIDi4700609
KEGGiact:ACLA_031210

Organism-specific databases

VEuPathDBiFungiDB:ACLA_031210

Phylogenomic databases

eggNOGiKOG1986, Eukaryota
HOGENOMiCLU_008658_3_0_1
OMAiFPPHYAE
OrthoDBi270617at2759

Family and domain databases

CDDicd11287, Sec23_C, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR037364, Sec23
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR037550, Sec23_C
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf
PANTHERiPTHR11141, PTHR11141, 1 hit
PfamiView protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC23_ASPCL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1CRW7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: January 23, 2007
Last modified: February 10, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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