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Entry version 82 (07 Oct 2020)
Sequence version 1 (23 Jan 2007)
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Protein

ABC transporter patM

Gene

patM

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ABC transporter; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (Probable). May be involved in the secretion of E-ascladiol to be converted to patulin by the secreted patulin synthase patE (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi811 – 818ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter patM1 Publication
Alternative name(s):
Patulin synthesis protein M1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:patM1 Publication
ORF Names:ACLA_093680
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri344612 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006701 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:ACLA_093680

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Transmembranei584 – 604HelicalSequence analysisAdd BLAST21
Transmembranei692 – 712HelicalSequence analysisAdd BLAST21
Transmembranei1135 – 1155HelicalSequence analysisAdd BLAST21
Transmembranei1181 – 1201HelicalSequence analysisAdd BLAST21
Transmembranei1223 – 1243HelicalSequence analysisAdd BLAST21
Transmembranei1249 – 1269HelicalSequence analysisAdd BLAST21
Transmembranei1372 – 1392HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Patulin was originally used as an antibiotic and specifically trialed to be used against the common cold, but it is no longer used for that purpose since it has been shown to induce immunological, neurological and gastrointestinal effects (PubMed:15082620). Genotoxic effects of patulin with dose-dependent increase in DNA strand breaks in brain, liver and kidneys have been detected in mice (PubMed:22222931). However, more recently, it has been proposed that patulin might also have anti-tumor properties (PubMed:26619846).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004371211 – 1397ABC transporter patMAdd BLAST1397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi772N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1318N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1CFM0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1CFM0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 346ABC transporter 1PROSITE-ProRule annotationAdd BLAST245
Domaini779 – 1016ABC transporter 2PROSITE-ProRule annotationAdd BLAST238

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0065, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_35_0_1

KEGG Orthology (KO)

More...
KOi
K08712

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRNVGIN

Database of Orthologous Groups

More...
OrthoDBi
324553at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR010929, PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF00005, ABC_tran, 2 hits
PF06422, PDR_CDR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1CFM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMLRNRPVK GSLDHDPQLS ADGTNTPAAS DGSDQRSDVI EKTAQLSEPI
60 70 80 90 100
ADSIRRFFEI RKLDGPDGTG VVFENISVEG SGTGAQAAPT ISSAARSAFG
110 120 130 140 150
VLSPLQHRLA GQFSRPILSG FSGTIDAGEM LLVIGKPGSG CTTFLKTLSY
160 170 180 190 200
MWDEYKDVHG DLTIGGHPIQ ESMVKRPQDI VFCAESDDHF PTLTVAETLR
210 220 230 240 250
FAIRARCGPE ASATEVDMMV AQLAKLVGLS QVMNTKVGDA YIRGVSGGER
260 270 280 290 300
RRVSLAEALA TCARLICLDN PTHGLDSSTA LEFIETMREW TSQSRCVTAM
310 320 330 340 350
SVYQASDAIM PYFDKVLVIN SGRQVFYGRI GDAKAYFERL GFECLPTTTL
360 370 380 390 400
SDFLNSMSAD PEVRRVQDGK QHLVPRTSEE FEAVFHASTF YQDLQRSLET
410 420 430 440 450
AKVEARTNPR PLVKARAFSL PLHHQIWYCA YRQFRIVTSD YSLWAVEPAT
460 470 480 490 500
IIVQSLVLGT LFRDQKRATQ SLFIFASALF YSVLVPALQS MAEFGNGFAQ
510 520 530 540 550
RPLILKQKRY RICRPIAYAL GLVTTDVVWK IAAICYNIPL YFLTGFQRTA
560 570 580 590 600
GNFFTWFCIV YLEHLALSMF FRSVAIFSPN MHRAVLPVGI FFNMYVLYTG
610 620 630 640 650
LYIPAPQMQV WLGWLRYLNP LYYAFESVMV NEFRDLSYQC SPSDLVPSGL
660 670 680 690 700
GYTDMANQVC AVLGSRSGEE SLSGMSYLEA QYGFGRSHLW RNVGINAAFF
710 720 730 740 750
VFFALCSGIG MERLKTPAGR LATVFYKGRP SIRNSQADSE SGAVHDDVPP
760 770 780 790 800
DVSRQLSGDQ HHLNANSERD KNHTLAWTGL CLDIETKDGT RRLLDNLNGW
810 820 830 840 850
VKSGQLKALM GVSGAGKTTL LNTLAGRSSI GTLTGTLALN GQLLPKFFRS
860 870 880 890 900
RMGYVQQQDI HLPTQSVREA LQMTARLRRD ESIPLEEKNA YVEKVIEWLD
910 920 930 940 950
MEDIAEALVG VPGAGLNLEQ RKRVSIGVEM ASKPEILFLD EPTSGLDGQS
960 970 980 990 1000
AFSIVRLLRR LADSGQAIVC TIHQPAAELV EQFDELYLLS RGGKLVYDGP
1010 1020 1030 1040 1050
LGTHCDKAIE YFEQHSRACG QGENPAEYFL DAIGAGSRKE VQADWVGLWQ
1060 1070 1080 1090 1100
QSQQSKDRER AEKALVPAEG QAPLAPARRS LYAVPFHVQL WVVVQRTWLY
1110 1120 1130 1140 1150
YWREPDYAMS KLWMSVGNAL LNSLTYLQSP NTQRGAYNRV FSAFMSLIVG
1160 1170 1180 1190 1200
PPLGLQVQPR FVTLRDIFVH REREGFTYHW LAFVFAGIIV ELPYTFLTSL
1210 1220 1230 1240 1250
VYWLLWYFPV GYFRTAPRAG YSFLMYELFA VFATSLAQMC ASLMPNIEAA
1260 1270 1280 1290 1300
FAANGFFFMF CNTFAGTLSP KPVTPSGWRW YYKVSPLFYL GEGVTVDVLQ
1310 1320 1330 1340 1350
DLPLRCAESE VSIFQPPNGT TCGQYAANFL QQATGFLLNT DSLSDCQYCR
1360 1370 1380 1390
YRDGQSYYQQ YGYDFANRYP NIGIFIGFIA FNFTMVLVMT YLTKIRR
Length:1,397
Mass (Da):156,194
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i943FB6B976B61217
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS027052 Genomic DNA Translation: EAW11669.1

NCBI Reference Sequences

More...
RefSeqi
XP_001273095.1, XM_001273094.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAW11669; EAW11669; ACLA_093680

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4704857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
act:ACLA_093680

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA Translation: EAW11669.1
RefSeqiXP_001273095.1, XM_001273094.1

3D structure databases

SMRiA1CFM0
ModBaseiSearch...

Proteomic databases

PRIDEiA1CFM0

Genome annotation databases

EnsemblFungiiEAW11669; EAW11669; ACLA_093680
GeneIDi4704857
KEGGiact:ACLA_093680

Organism-specific databases

EuPathDBiFungiDB:ACLA_093680

Phylogenomic databases

eggNOGiKOG0065, Eukaryota
HOGENOMiCLU_000604_35_0_1
KOiK08712
OMAiWRNVGIN
OrthoDBi324553at2759

Family and domain databases

CDDicd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR027417, P-loop_NTPase
IPR010929, PDR_CDR_ABC
PfamiView protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF00005, ABC_tran, 2 hits
PF06422, PDR_CDR, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPATM_ASPCL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1CFM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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