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UniProtKB - A1CEK6 (HSE1_ASPCL)
Protein
Class E vacuolar protein-sorting machinery protein hse1
Gene
hse1
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
Status
Functioni
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
By similarityGO - Molecular functioni
- phosphatidylinositol binding Source: InterPro
- ubiquitin binding Source: InterPro
GO - Biological processi
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Class E vacuolar protein-sorting machinery protein hse1 |
Gene namesi | Name:hse1 ORF Names:ACLA_089980 |
Organismi | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) |
Taxonomic identifieri | 344612 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:ACLA_089980 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Endosome
- endosome membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292486 | 1 – 599 | Class E vacuolar protein-sorting machinery protein hse1Add BLAST | 599 |
Interactioni
Subunit structurei
Component of the ESCRT-0 complex composed of HSE1 and VPS27.
By similarityGO - Molecular functioni
- ubiquitin binding Source: InterPro
Protein-protein interaction databases
STRINGi | 5057.CADACLAP00008355 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 145 | VHSPROSITE-ProRule annotationAdd BLAST | 130 | |
Domaini | 162 – 181 | UIMCuratedAdd BLAST | 20 | |
Domaini | 215 – 274 | SH3PROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 140 – 163 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 177 – 212 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 368 – 599 | DisorderedSequence analysisAdd BLAST | 232 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 191 – 212 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 376 – 408 | Pro residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 409 – 426 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 436 – 451 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 458 – 472 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 498 – 522 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 523 – 571 | Pro residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 580 – 599 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the STAM family.Curated
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG2199, Eukaryota |
HOGENOMi | CLU_010104_1_1_1 |
OMAi | AHALCQN |
OrthoDBi | 906159at2759 |
Family and domain databases
Gene3Di | 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR004152, GAT_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR002014, VHS_dom |
Pfami | View protein in Pfam PF03127, GAT, 1 hit PF00018, SH3_1, 1 hit PF00790, VHS, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50179, VHS, 1 hit |
i Sequence
Sequence statusi: Complete.
A1CEK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM
60 70 80 90 100
IKRLAHRNAN VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR
110 120 130 140 150
NTHQQVKSKI LERMHDWTRM FSSNPDFGIM EQAYMKLKTQ NPNLQPPSKP
160 170 180 190 200
VKKEITQADR QKEEEELQMA LALSIREKSD AGPAPQAESS APASAPVSQT
210 220 230 240 250
QAAAPQAVPS GTSAATVSRV RALFDFQPSE PGELQFRKGD IIAVLESVYK
260 270 280 290 300
DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEADV FGQIKNVEKL
310 320 330 340 350
LTLLSTRSSE LNVQDNEEIT ALYHSTLAIR PKLIELIGKY SQKKDEFTQL
360 370 380 390 400
NEKFIKARRD YESLLEASMS HPPQPQYARP GQPPYGYPAP TGPHGYPQGA
410 420 430 440 450
PQPDPQRYFS PRPQDQTHMY PPTSQSPDPR GRTPPAGPTM QQQQQQPPAE
460 470 480 490 500
SFQPMHHRPE STYDNPQELG TSVYDSPVEY PPANQRFQYP PGASAPPGVH
510 520 530 540 550
QQLQQQQQEY SPSNYSPEDT TNPPTANFPP QPQQSQLPYP TGPAGHQAPP
560 570 580 590
SHQPPPVPGG ASKPSPYPSL TPGAPSAGEY QAYNPSQASA SSNPASFYR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS027052 Genomic DNA Translation: EAW11305.1 |
RefSeqi | XP_001272731.1, XM_001272730.1 |
Genome annotation databases
EnsemblFungii | EAW11305; EAW11305; ACLA_089980 |
GeneIDi | 4705069 |
KEGGi | act:ACLA_089980 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS027052 Genomic DNA Translation: EAW11305.1 |
RefSeqi | XP_001272731.1, XM_001272730.1 |
3D structure databases
AlphaFoldDBi | A1CEK6 |
SMRi | A1CEK6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5057.CADACLAP00008355 |
Genome annotation databases
EnsemblFungii | EAW11305; EAW11305; ACLA_089980 |
GeneIDi | 4705069 |
KEGGi | act:ACLA_089980 |
Organism-specific databases
VEuPathDBi | FungiDB:ACLA_089980 |
Phylogenomic databases
eggNOGi | KOG2199, Eukaryota |
HOGENOMi | CLU_010104_1_1_1 |
OMAi | AHALCQN |
OrthoDBi | 906159at2759 |
Family and domain databases
Gene3Di | 1.25.40.90, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR004152, GAT_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR002014, VHS_dom |
Pfami | View protein in Pfam PF03127, GAT, 1 hit PF00018, SH3_1, 1 hit PF00790, VHS, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50179, VHS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HSE1_ASPCL | |
Accessioni | A1CEK6Primary (citable) accession number: A1CEK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families