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Protein

Vacuolar protein sorting-associated protein 27

Gene

vps27

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 225FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 27
Gene namesi
Name:vps27
ORF Names:ACLA_089930
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_089930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002925071 – 714Vacuolar protein sorting-associated protein 27Add BLAST714

Proteomic databases

PRIDEiA1CEK1

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of HSE1 and VPS27.

Protein-protein interaction databases

STRINGi5057.CADACLAP00008334

Structurei

3D structure databases

ProteinModelPortaliA1CEK1
SMRiA1CEK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 147VHSPROSITE-ProRule annotationAdd BLAST132
Domaini261 – 280UIM 1PROSITE-ProRule annotationAdd BLAST20
Domaini306 – 325UIM 2PROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi508 – 705Pro-richAdd BLAST198

Domaini

The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns3P) which is required for the association to endosomal membranes.
Both IUM domains are necessary for efficient binding to ubiquitin.By similarity

Sequence similaritiesi

Belongs to the VPS27 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 225FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000048363
KOiK12182
OMAiYMYPAGA
OrthoDBiEOG092C214M

Family and domain databases

Gene3Di1.25.40.90, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR017073 Ubi-bd_Hrs_VPS27
IPR003903 UIM_dom
IPR002014 VHS_dom
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF02809 UIM, 2 hits
PF00790 VHS, 1 hit
PIRSFiPIRSF036956 Hrs_Vps27, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00726 UIM, 2 hits
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50330 UIM, 2 hits
PS50179 VHS, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

A1CEK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGWFSSSSP LDEQVERATS SSLEDIALNL EISDLIRSKS VQPKEAMRSL
60 70 80 90 100
KRRLENRNPN VQIATLKLTD TCVKNGGTHF LAEIASREYL DNMVSLLTAE
110 120 130 140 150
GAPLNSDVKE KMLELIQDWA MAAQGRMDLN YLGETYRKLQ SEGFRFPPKS
160 170 180 190 200
EISGSMLESS APPEWIDHDV CMRCRTPFSF MNRKHHCRNC GNVFDAQCSS
210 220 230 240 250
KTLPLPHLGI LQPVRVDDGC YAKLTSKSFT PSTLSDRSAF KNNSITKANA
260 270 280 290 300
MEPRGARAEG GFDDDLRRAL QMSLEEAQNR GSGGYIPQPK VNEPSNATIQ
310 320 330 340 350
PHPQDEEDAD LKAAIEASLR DMEEHKKKHA AALKNNTVAT DSTAQDTGSA
360 370 380 390 400
LPMPKNPYEL SPVEVENIHL FAALVDRLQH QPPGTILRES QIQELYESIG
410 420 430 440 450
TLRPKLARSY GETMSKHDTL LDLHAKLSTV VRYYDRMLEE RLSSAYSQHS
460 470 480 490 500
LGYGQAPGGS QYPNMYPSMP SQAVEGKSGA ENFYYGNAVP ERSPPAHSTY
510 520 530 540 550
AYQQGIAPSG PMSSGMYPQP GQALPSNPAW NGNAPPTTAS PQLSTSSTPF
560 570 580 590 600
PNHPVGYPAP SAPTQYYAPT APPEQDANTY STPRPGETEV SHQASPVMRR
610 620 630 640 650
DSYYQSAGAP PSAPEPSPPS EHGQSSGYMQ YADSRTMPPN SQYPPQQQPS
660 670 680 690 700
AQPYYSQQPP PQATPHTTYS QPPAAPYETH PVADVSPIGA PVPSAPYQQP
710
APTRPAVEES LIEL
Length:714
Mass (Da):78,156
Last modified:January 23, 2007 - v1
Checksum:i56D01CAF71B00D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA Translation: EAW11300.1
RefSeqiXP_001272726.1, XM_001272725.1

Genome annotation databases

EnsemblFungiiEAW11300; EAW11300; ACLA_089930
GeneIDi4705079
KEGGiact:ACLA_089930

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027052 Genomic DNA Translation: EAW11300.1
RefSeqiXP_001272726.1, XM_001272725.1

3D structure databases

ProteinModelPortaliA1CEK1
SMRiA1CEK1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00008334

Proteomic databases

PRIDEiA1CEK1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAW11300; EAW11300; ACLA_089930
GeneIDi4705079
KEGGiact:ACLA_089930

Organism-specific databases

EuPathDBiFungiDB:ACLA_089930

Phylogenomic databases

HOGENOMiHOG000048363
KOiK12182
OMAiYMYPAGA
OrthoDBiEOG092C214M

Family and domain databases

Gene3Di1.25.40.90, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR008942 ENTH_VHS
IPR017073 Ubi-bd_Hrs_VPS27
IPR003903 UIM_dom
IPR002014 VHS_dom
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF02809 UIM, 2 hits
PF00790 VHS, 1 hit
PIRSFiPIRSF036956 Hrs_Vps27, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00726 UIM, 2 hits
SM00288 VHS, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50330 UIM, 2 hits
PS50179 VHS, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPS27_ASPCL
AccessioniPrimary (citable) accession number: A1CEK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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