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Protein

5'-3' exoribonuclease 1

Gene

ACLA_002030

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseUniRule annotationImported, Hydrolase, Nuclease, RNA-bindingUniRule annotation
Biological processNonsense-mediated mRNA decayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
5'-3' exoribonuclease 1UniRule annotation (EC:3.1.13.-UniRule annotation)
Gene namesi
ORF Names:ACLA_002030Imported
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_002030

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00000340

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 227XRN_NInterPro annotationAdd BLAST227

Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000160331
KOiK12618
OMAiWVLMGFM
OrthoDBiEOG092C068M

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

Sequencei

Sequence statusi: Complete.

A1C524-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVPKFFRWL SERYPTISML IAENRIPEFD ALYLDMNGII HNCTHKDSDS
60 70 80 90 100
PTFRMTEDKM FIAIFNYIEH LYGKIKPKKL FFMAIDGVAP RAKMNQQRAR
110 120 130 140 150
RFRTALDAEV AKEKAIAQGI EMPKEDAFDS NCITPGTEFM AKLTQQLKYF
160 170 180 190 200
ISKKISEDKD WQGVEIVLSG HEVPGEGEHK IMEYIRHAKA QPDYDSNIRH
210 220 230 240 250
CLYGLDADLI MLGLLSHDPH FCLLREEVTF GRQVQKKPKE LEHQNFFLLH
260 270 280 290 300
LCMVREYLEL EFQELEQEGV LDFPFDMERV IDDFILMAFF VGNDFLPNLP
310 320 330 340 350
NLHINEGALA LMFKIYKEVL PKMGGYVNEG GVINLKRLGM LVEALSDVEF
360 370 380 390 400
RFFEVEYSDA KWITAKRKAI ENDFEPPEKQ RGLTVTPAQK ELFKEVKKYV
410 420 430 440 450
LNRPEKETGS KPLDLPSALP ARDRKFVEQL ANDLHVPWTT VADEHGDRFI
460 470 480 490 500
RLQLPTNDDD DSEEEEDEEA SMAVRRVIRR YENAKVQEIS PEEAQKAAEQ
510 520 530 540 550
KYEEKFQEWK DKYYMSKFGW GLDNHEEMRK LTENYVQGLQ WVLYYYYRGI
560 570 580 590 600
ASWPWFFKYH YAPMISDVTK GLKADMNFQL GQPFKPYEQL MGVLPDRSKK
610 620 630 640 650
IVPAAYRDLM TSPDSPIIDF YPRDFELDMN GKKMEWEAVV KIPFIEERRL
660 670 680 690 700
LDALATKSHL LTPEEKVRND FGVSLKFTYS PDANYSYPSS LPGVFPDIPN
710 720 730 740 750
CHCIENVFDL PTMDGLEPYI GLVDGVQLGA AALAGFPSLK TLPHVGQLGF
760 770 780 790 800
HGVCVFQQES RNESMVITIL DPGSRSSVEL AKSKLGKRVF VGYPFLQEAL
810 820 830 840 850
VVRVSDELFD YIIPDGEEHP VPIPHTEAQI DQWRKKADKI EGTYSRRLGT
860 870 880 890 900
VIGPVDSMVH VQLLKGLIKT DEGATIKEFA DILGQETDYA LQLVVDEVIN
910 920 930 940 950
PDERFIERDA LPIEKEFPEG SRAFFLGDYN YGRPVHVTGH DDGKVNGLIA
960 970 980 990 1000
SIPGREPEFG KERAREAEKL CPYMPSFAIA RSLRLNPLVL AKITSSFSVD
1010 1020 1030 1040 1050
VEGQRVNLGL NLKFEARKQK VLGYSRRGDS GWEFSQRTVD LLQQYMIKFP
1060 1070 1080 1090 1100
EFIAGIQRNP QRDRYNPADF YPEDVALQKI QEIKDWLKSI EAKNFERVPL
1110 1120 1130 1140 1150
EAEQLDSEVV KLIEQDADRL MQSQPQMQAK KVRGVPRSAL LRPSDVEQRL
1160 1170 1180 1190 1200
QNQSFKLGDR VVYAQDSGKV PIATRGTVVG LTRTSRAMLL DVVFDVSFMS
1210 1220 1230 1240 1250
GTTLGDRCSP FRGQTVLASS VLNVSYRQLL ASTRAAASQQ SQSQPSPLTV
1260 1270 1280 1290 1300
AGYGAPLGPN GQGQLREAAA PPPLSGSYRG AVSGVSNGRG NGRGRGGRGA
1310 1320 1330 1340 1350
SNGGSNPTSL PFRPHPNGSE NRGGRGRGGM YRTRGGYVSV DNSNPDAGII
1360 1370 1380 1390 1400
KNNPNFRPQN YSQVPPPKGL DRGSGRGGRG GFRGSDKGNG SRGRGGQRGR

GAATTNNN
Length:1,408
Mass (Da):158,997
Last modified:January 23, 2007 - v1
Checksum:i86148279A144F867
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027004 Genomic DNA Translation: EAW14792.1
RefSeqiXP_001276218.1, XM_001276217.1

Genome annotation databases

EnsemblFungiiEAW14792; EAW14792; ACLA_002030
GeneIDi4708570
KEGGiact:ACLA_002030

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027004 Genomic DNA Translation: EAW14792.1
RefSeqiXP_001276218.1, XM_001276217.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00000340

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAW14792; EAW14792; ACLA_002030
GeneIDi4708570
KEGGiact:ACLA_002030

Organism-specific databases

EuPathDBiFungiDB:ACLA_002030

Phylogenomic databases

HOGENOMiHOG000160331
KOiK12618
OMAiWVLMGFM
OrthoDBiEOG092C068M

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1C524_ASPCL
AccessioniPrimary (citable) accession number: A1C524
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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