Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5'-3' exoribonuclease 1

Gene

ACLA_002030

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonucleaseUniRule annotationImported, Hydrolase, Nuclease, RNA-bindingUniRule annotation
Biological processNonsense-mediated mRNA decayUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-3' exoribonuclease 1UniRule annotation (EC:3.1.13.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ACLA_002030Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri344612 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006701 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:ACLA_002030

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5057.CADACLAP00000340

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 227XRN_NInterPro annotationAdd BLAST227

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000160331

KEGG Orthology (KO)

More...
KOi
K12618

Identification of Orthologs from Complete Genome Data

More...
OMAi
YPAISQL

Database of Orthologous Groups

More...
OrthoDBi
685597at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2

The PANTHER Classification System

More...
PANTHERi
PTHR12341 PTHR12341, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03159 XRN_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006743 Exonuclease_Xnr1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1C524-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVPKFFRWL SERYPTISML IAENRIPEFD ALYLDMNGII HNCTHKDSDS
60 70 80 90 100
PTFRMTEDKM FIAIFNYIEH LYGKIKPKKL FFMAIDGVAP RAKMNQQRAR
110 120 130 140 150
RFRTALDAEV AKEKAIAQGI EMPKEDAFDS NCITPGTEFM AKLTQQLKYF
160 170 180 190 200
ISKKISEDKD WQGVEIVLSG HEVPGEGEHK IMEYIRHAKA QPDYDSNIRH
210 220 230 240 250
CLYGLDADLI MLGLLSHDPH FCLLREEVTF GRQVQKKPKE LEHQNFFLLH
260 270 280 290 300
LCMVREYLEL EFQELEQEGV LDFPFDMERV IDDFILMAFF VGNDFLPNLP
310 320 330 340 350
NLHINEGALA LMFKIYKEVL PKMGGYVNEG GVINLKRLGM LVEALSDVEF
360 370 380 390 400
RFFEVEYSDA KWITAKRKAI ENDFEPPEKQ RGLTVTPAQK ELFKEVKKYV
410 420 430 440 450
LNRPEKETGS KPLDLPSALP ARDRKFVEQL ANDLHVPWTT VADEHGDRFI
460 470 480 490 500
RLQLPTNDDD DSEEEEDEEA SMAVRRVIRR YENAKVQEIS PEEAQKAAEQ
510 520 530 540 550
KYEEKFQEWK DKYYMSKFGW GLDNHEEMRK LTENYVQGLQ WVLYYYYRGI
560 570 580 590 600
ASWPWFFKYH YAPMISDVTK GLKADMNFQL GQPFKPYEQL MGVLPDRSKK
610 620 630 640 650
IVPAAYRDLM TSPDSPIIDF YPRDFELDMN GKKMEWEAVV KIPFIEERRL
660 670 680 690 700
LDALATKSHL LTPEEKVRND FGVSLKFTYS PDANYSYPSS LPGVFPDIPN
710 720 730 740 750
CHCIENVFDL PTMDGLEPYI GLVDGVQLGA AALAGFPSLK TLPHVGQLGF
760 770 780 790 800
HGVCVFQQES RNESMVITIL DPGSRSSVEL AKSKLGKRVF VGYPFLQEAL
810 820 830 840 850
VVRVSDELFD YIIPDGEEHP VPIPHTEAQI DQWRKKADKI EGTYSRRLGT
860 870 880 890 900
VIGPVDSMVH VQLLKGLIKT DEGATIKEFA DILGQETDYA LQLVVDEVIN
910 920 930 940 950
PDERFIERDA LPIEKEFPEG SRAFFLGDYN YGRPVHVTGH DDGKVNGLIA
960 970 980 990 1000
SIPGREPEFG KERAREAEKL CPYMPSFAIA RSLRLNPLVL AKITSSFSVD
1010 1020 1030 1040 1050
VEGQRVNLGL NLKFEARKQK VLGYSRRGDS GWEFSQRTVD LLQQYMIKFP
1060 1070 1080 1090 1100
EFIAGIQRNP QRDRYNPADF YPEDVALQKI QEIKDWLKSI EAKNFERVPL
1110 1120 1130 1140 1150
EAEQLDSEVV KLIEQDADRL MQSQPQMQAK KVRGVPRSAL LRPSDVEQRL
1160 1170 1180 1190 1200
QNQSFKLGDR VVYAQDSGKV PIATRGTVVG LTRTSRAMLL DVVFDVSFMS
1210 1220 1230 1240 1250
GTTLGDRCSP FRGQTVLASS VLNVSYRQLL ASTRAAASQQ SQSQPSPLTV
1260 1270 1280 1290 1300
AGYGAPLGPN GQGQLREAAA PPPLSGSYRG AVSGVSNGRG NGRGRGGRGA
1310 1320 1330 1340 1350
SNGGSNPTSL PFRPHPNGSE NRGGRGRGGM YRTRGGYVSV DNSNPDAGII
1360 1370 1380 1390 1400
KNNPNFRPQN YSQVPPPKGL DRGSGRGGRG GFRGSDKGNG SRGRGGQRGR

GAATTNNN
Length:1,408
Mass (Da):158,997
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86148279A144F867
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS027004 Genomic DNA Translation: EAW14792.1

NCBI Reference Sequences

More...
RefSeqi
XP_001276218.1, XM_001276217.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAW14792; EAW14792; ACLA_002030

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4708570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
act:ACLA_002030

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027004 Genomic DNA Translation: EAW14792.1
RefSeqiXP_001276218.1, XM_001276217.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi5057.CADACLAP00000340

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAW14792; EAW14792; ACLA_002030
GeneIDi4708570
KEGGiact:ACLA_002030

Organism-specific databases

EuPathDBiFungiDB:ACLA_002030

Phylogenomic databases

HOGENOMiHOG000160331
KOiK12618
OMAiYPAISQL
OrthoDBi685597at2759

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1C524_ASPCL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1C524
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again