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Protein

UvrABC system protein C

Gene

uvrC

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciECOL405955:G1G7D-2118-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:Ecok1_17610
ORF Names:APECO1_955
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008216 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000777821 – 610UvrABC system protein CAdd BLAST610

Proteomic databases

PRIDEiA1AC65

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1AC65
SMRiA1AC65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 94GIY-YIGUniRule annotationAdd BLAST79
Domaini204 – 239UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279961
KOiK03703
OMAiLFPIRQC

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

A1AC65-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDQFDAKAF LKTVTSQPGV YRMYDAGGTV IYVGKAKDLK KRLSSYFRSN
60 70 80 90 100
LASRKTEALV AQIQQIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK
110 120 130 140 150
SYPFIFLSGD THPRLAMHRG AKHAKGEYFG PFPNGYAVRE TLALLQKIFP
160 170 180 190 200
IRQCENSVYR NRSRPCLQYQ IGRCLGPCVE GLVSEEEYAQ QVEYVRLFLS
210 220 230 240 250
GKDDQVLTQL ISRMETASQN LEFEEAARIR DQIQAVRRVT EKQFVSNTGD
260 270 280 290 300
DLDVIGVAFD AGMACVHVLF IRQGKVLGSR SYFPKVPGST ELSEVVETFV
310 320 330 340 350
GQFYLQGSQM RTLPGEILLD FNLSDKTLLA DSLSELAGRK INVQTKPRGD
360 370 380 390 400
RARYLKLART NAATALTSKL SQQSTVHQRL TALASVLKLP EVKRMECFDI
410 420 430 440 450
SHTMGEQTVA SCVVFDANGP LRAEYRRYNI TGITPGDDYA AMNQVLRRRY
460 470 480 490 500
GKAIDDSKIP DVILIDGGKG QLAQAKNVFA ELDVSWDKNH PLLLGVAKGA
510 520 530 540 550
DRKAGLETLF FEPEGEGFSL PPDSPALHVI QHIRDESHDH AIGGHRKKRA
560 570 580 590 600
KVKNTSSLET IEGIGPKRRQ MLLKYMGGLQ GLRNASVEEI AKVPGISQGL
610
AEKIFWSLKH
Length:610
Mass (Da):68,232
Last modified:January 23, 2007 - v1
Checksum:i1154F55DBB8BF7DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA Translation: ABJ01255.1
RefSeqiWP_001283434.1, NC_008563.1

Genome annotation databases

EnsemblBacteriaiABJ01255; ABJ01255; APECO1_955
KEGGiecv:APECO1_955

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA Translation: ABJ01255.1
RefSeqiWP_001283434.1, NC_008563.1

3D structure databases

ProteinModelPortaliA1AC65
SMRiA1AC65
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA1AC65

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ01255; ABJ01255; APECO1_955
KEGGiecv:APECO1_955

Phylogenomic databases

HOGENOMiHOG000279961
KOiK03703
OMAiLFPIRQC

Enzyme and pathway databases

BioCyciECOL405955:G1G7D-2118-MONOMER

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUVRC_ECOK1
AccessioniPrimary (citable) accession number: A1AC65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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