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Protein

Uridylate kinase

Gene

pyrH

Organism
Escherichia coli O1:K1 / APEC
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of UMP to UDP.UniRule annotation

Catalytic activityi

ATP + UMP = ADP + UDP.UniRule annotation

Activity regulationi

Allosterically activated by GTP. Inhibited by UTP.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UDP from UMP (UMPK route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridylate kinase (pyrH)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP from UMP (UMPK route), the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57UMP; via amide nitrogenUniRule annotation1
Binding sitei58ATP; via amide nitrogenUniRule annotation1
Binding sitei62ATPUniRule annotation1
Binding sitei77UMPUniRule annotation1
Binding sitei165ATPUniRule annotation1
Binding sitei171ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei174ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 18ATPUniRule annotation4
Nucleotide bindingi138 – 145UMPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Kinase, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00159;UER00275

Names & Taxonomyi

Protein namesi
Recommended name:
Uridylate kinaseUniRule annotation (EC:2.7.4.22UniRule annotation)
Short name:
UKUniRule annotation
Alternative name(s):
Uridine monophosphate kinaseUniRule annotation
Short name:
UMP kinaseUniRule annotation
Short name:
UMPKUniRule annotation
Gene namesi
Name:pyrHUniRule annotation
Ordered Locus Names:Ecok1_01610
ORF Names:APECO1_1816
OrganismiEscherichia coli O1:K1 / APEC
Taxonomic identifieri405955 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008216 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000539211 – 241Uridylate kinaseAdd BLAST241

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1A7L5
SMRiA1A7L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 28Involved in allosteric activation by GTPUniRule annotation6

Sequence similaritiesi

Belongs to the UMP kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000047187
KOiK09903
OMAiPIIVFDM

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01220_B PyrH_B, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR011817 Uridylate_kinase
IPR015963 Uridylate_kinase_bac
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF005650 Uridylate_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR02075 pyrH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A1A7L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATNAKPVYK RILLKLSGEA LQGTEGFGID ASILDRMAQE IKELVELGIQ
60 70 80 90 100
VGVVIGGGNL FRGAGLAKAG MNRVVGDHMG MLATVMNGLA MRDALHRAYV
110 120 130 140 150
NARLMSAIPL NGVCDSYSWA EAISLLRNNR VVILSAGTGN PFFTTDSAAC
160 170 180 190 200
LRGIEIEADV VLKATKVDGV FTADPAKDPT ATMYEQLTYS EVLEKELKVM
210 220 230 240
DLAAFTLARD HKLPIRVFNM NKPGALRRVV MGEKEGTLIT E
Length:241
Mass (Da):25,970
Last modified:January 23, 2007 - v1
Checksum:i82EFA75F7226E201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000468 Genomic DNA Translation: ABI99654.1
RefSeqiWP_000224573.1, NC_008563.1

Genome annotation databases

EnsemblBacteriaiABI99654; ABI99654; APECO1_1816
KEGGiecv:APECO1_1816

Similar proteinsi

Entry informationi

Entry nameiPYRH_ECOK1
AccessioniPrimary (citable) accession number: A1A7L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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