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Protein

Protein disulfide isomerase pTAC5, chloroplastic

Gene

PTAC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits zinc-dependent disulfide isomerase activity. Required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription.1 Publication

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri318 – 387CR-typePROSITE-ProRule annotationAdd BLAST70

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein disulfide isomerase activity Source: CACAO

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processStress response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase pTAC5, chloroplastic1 Publication (EC:5.3.4.11 Publication)
Alternative name(s):
Protein PLASTID TRANSCRIPTIONALLY ACTIVE 51 Publication
Short name:
pTAC51 Publication
Gene namesi
Name:PTAC51 Publication
Ordered Locus Names:At4g13670Imported
ORF Names:F18A5.60Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G13670
TAIRilocus:2119475 AT4G13670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

Pathology & Biotechi

Disruption phenotypei

Ivory phenotype under heat stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40ChloroplastSequence analysisAdd BLAST40
ChainiPRO_000044169741 – 387Protein disulfide isomerase pTAC5, chloroplasticSequence analysisAdd BLAST347

Proteomic databases

PaxDbiA1A6M1

PTM databases

iPTMnetiA1A6M1

Expressioni

Gene expression databases

ExpressionAtlasiA1A6M1 baseline and differential

Interactioni

Subunit structurei

Interacts with HSP21; the formed complex associates with the plastid-encoded RNA polymerase (PEP) complex not only during transcription initiation, but also during elongation and termination, and with a stronger efficiency in illuminated chloroplasts. Binds to promoter regions of PEP-dependent genes, especially after a heat stress (PubMed:23922206). Interacts with FLN2 (PubMed:24019900).2 Publications

Protein-protein interaction databases

IntActiA1A6M1, 1 interactor
MINTiA1A6M1
STRINGi3702.AT4G13670.1

Structurei

3D structure databases

ProteinModelPortaliA1A6M1
SMRiA1A6M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 106Sequence analysisAdd BLAST35
Coiled coili143 – 163Sequence analysisAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri318 – 387CR-typePROSITE-ProRule annotationAdd BLAST70

Keywords - Domaini

Coiled coil, Transit peptide, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH9F Eukaryota
ENOG4111TC7 LUCA
HOGENOMiHOG000116609
InParanoidiA1A6M1
KOiK22519
OMAiIREEQRW
OrthoDBiEOG09360MMA
PhylomeDBiA1A6M1

Family and domain databases

Gene3Di1.10.101.10, 1 hit
InterProiView protein in InterPro
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PfamiView protein in Pfam
PF01471 PG_binding_1, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF57938 SSF57938, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A1A6M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSLPLSL PFPLRSLTST TRSLPFQCSP LFFSIPSSIV CFSTQNPDRE
60 70 80 90 100
EVRWLREEQR WIREEQRWIR EEQRWIRERE SLLQEISDLQ LRIQSLESRN
110 120 130 140 150
SQLGNSIPDT ISNIAALLQV LKEKNRISES GLSATPMVLE STREQIVEEV
160 170 180 190 200
EEEEKRVIIA EEKVRVSEPV KKIKRRILKV GSEGDDVQAL QEALLKLGFY
210 220 230 240 250
SGEEDMEFSS FSSGTASAVK TWQASLGVRE DGVMTAELLQ RLFMDEDVET
260 270 280 290 300
DKDEASTMKK EEAGNGAVFT SVTQVPEKKQ SIVKDQSDRE VDVTQNRVFL
310 320 330 340 350
LGENRWEDPS RLIGRNKPVD RSESTNTKTR CITCRGEGRL MCLECDGTGE
360 370 380
PNIEPQFMEW VGEDTKCPYC EGLGYTVCDV CDGKKNL
Length:387
Mass (Da):44,020
Last modified:January 23, 2007 - v1
Checksum:i989E5E907014342B
GO
Isoform 2 (identifier: A1A6M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-278: EAGNGAVFTSVTQVPEK → SSYDRIWTPIVCFWQAC
     279-387: Missing.

Note: Derived from EST data. No experimental confirmation available.Imported
Show »
Length:278
Mass (Da):31,986
Checksum:i22702960EC2DBF24
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B4I3A0A1P8B4I3_ARATH
Plastid transcriptionally active 5
PTAC5 At4g13670, F18A5.60, F18A5_60
350Annotation score:

Sequence cautioni

The sequence CAB36831 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78409 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059090262 – 278EAGNG…QVPEK → SSYDRIWTPIVCFWQAC in isoform 2. Add BLAST17
Alternative sequenceiVSP_059091279 – 387Missing in isoform 2. Add BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035528 Genomic DNA Translation: CAB36831.1 Sequence problems.
AL161537 Genomic DNA Translation: CAB78409.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83311.1
CP002687 Genomic DNA Translation: ANM66498.1
CP002687 Genomic DNA Translation: ANM66499.1
BT029541 mRNA Translation: ABL66797.1
PIRiT05236
RefSeqiNP_001328389.1, NM_001340874.1 [A1A6M1-2]
NP_001328390.1, NM_001340872.1 [A1A6M1-2]
NP_193103.2, NM_117441.4 [A1A6M1-1]
UniGeneiAt.33352

Genome annotation databases

EnsemblPlantsiAT4G13670.1; AT4G13670.1; AT4G13670 [A1A6M1-1]
AT4G13670.2; AT4G13670.2; AT4G13670 [A1A6M1-2]
AT4G13670.4; AT4G13670.4; AT4G13670 [A1A6M1-2]
GeneIDi827001
GrameneiAT4G13670.1; AT4G13670.1; AT4G13670 [A1A6M1-1]
AT4G13670.2; AT4G13670.2; AT4G13670 [A1A6M1-2]
AT4G13670.4; AT4G13670.4; AT4G13670 [A1A6M1-2]
KEGGiath:AT4G13670

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035528 Genomic DNA Translation: CAB36831.1 Sequence problems.
AL161537 Genomic DNA Translation: CAB78409.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83311.1
CP002687 Genomic DNA Translation: ANM66498.1
CP002687 Genomic DNA Translation: ANM66499.1
BT029541 mRNA Translation: ABL66797.1
PIRiT05236
RefSeqiNP_001328389.1, NM_001340874.1 [A1A6M1-2]
NP_001328390.1, NM_001340872.1 [A1A6M1-2]
NP_193103.2, NM_117441.4 [A1A6M1-1]
UniGeneiAt.33352

3D structure databases

ProteinModelPortaliA1A6M1
SMRiA1A6M1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA1A6M1, 1 interactor
MINTiA1A6M1
STRINGi3702.AT4G13670.1

PTM databases

iPTMnetiA1A6M1

Proteomic databases

PaxDbiA1A6M1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G13670.1; AT4G13670.1; AT4G13670 [A1A6M1-1]
AT4G13670.2; AT4G13670.2; AT4G13670 [A1A6M1-2]
AT4G13670.4; AT4G13670.4; AT4G13670 [A1A6M1-2]
GeneIDi827001
GrameneiAT4G13670.1; AT4G13670.1; AT4G13670 [A1A6M1-1]
AT4G13670.2; AT4G13670.2; AT4G13670 [A1A6M1-2]
AT4G13670.4; AT4G13670.4; AT4G13670 [A1A6M1-2]
KEGGiath:AT4G13670

Organism-specific databases

AraportiAT4G13670
TAIRilocus:2119475 AT4G13670

Phylogenomic databases

eggNOGiENOG410IH9F Eukaryota
ENOG4111TC7 LUCA
HOGENOMiHOG000116609
InParanoidiA1A6M1
KOiK22519
OMAiIREEQRW
OrthoDBiEOG09360MMA
PhylomeDBiA1A6M1

Miscellaneous databases

PROiPR:A1A6M1

Gene expression databases

ExpressionAtlasiA1A6M1 baseline and differential

Family and domain databases

Gene3Di1.10.101.10, 1 hit
InterProiView protein in InterPro
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PfamiView protein in Pfam
PF01471 PG_binding_1, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF57938 SSF57938, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTAC5_ARATH
AccessioniPrimary (citable) accession number: A1A6M1
Secondary accession number(s): A0A1P8B4I4, Q9SVP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2017
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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