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UniProtKB - A1A6K6 (NSRA_ARATH)
Protein
Nuclear speckle RNA-binding protein A
Gene
NSRA
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Alternative splicing (AS) regulator that binds to specific mRNAs and modulates auxin effects on the transcriptome. Displaced from its targets upon binding to AS competitor long non-coding RNA (ASCO-RNA).
1 PublicationGO - Molecular functioni
- mRNA binding Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear speckle RNA-binding protein A1 PublicationShort name: AtNSRA1 Publication |
Gene namesi | Name:NSRA1 Publication Ordered Locus Names:At1g76940Imported ORF Names:F22K20.4Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress)Imported |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G76940 |
TAIRi | locus:2025232, AT1G76940 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
Note: Relocalizes to cytoplasmic bodies in trichoblast cells containing root hairs or when coexpressed with Medicago enod40 RNA.1 Publication
Nucleus
- nuclear speck Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
No visible phenotype. Nsra and nsrb double mutants are less sensitive to auxin.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000434146 | 1 – 233 | Nuclear speckle RNA-binding protein AAdd BLAST | 233 |
Proteomic databases
PaxDbi | A1A6K6 |
ProteomicsDBi | 249072 [A1A6K6-1] |
Expressioni
Tissue specificityi
Expressed in root meristems, lateral root primordia and root vascular tissues.1 Publication
Inductioni
Constitutively expressed.1 Publication
Gene expression databases
ExpressionAtlasi | A1A6K6, baseline and differential |
Genevisiblei | A1A6K6, AT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 136 – 222 | RRMPROSITE-ProRule annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 54 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 68 – 92 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 214 – 233 | DisorderedSequence analysisAdd BLAST | 20 |
Phylogenomic databases
eggNOGi | ENOG502S9VX, Eukaryota |
HOGENOMi | CLU_078642_1_1_1 |
InParanoidi | A1A6K6 |
OMAi | AMDEFMM |
PhylomeDBi | A1A6K6 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: A1A6K6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADGYWNQQR QQHHPPGGPM KRPRSDFEAP SSTMTIGHGG GYYPRDEDLD
60 70 80 90 100
VPDTRTIGSA YDRYLQSVQS GEGGSVSMGR SGGGGGGGGG NVQTIDDFML
110 120 130 140 150
RRGGVLPLDH GPNGHTIGFD PPEPVGRRNL PSDASNTLYV EGLPSNCSRR
160 170 180 190 200
EVAHIFRPFV GYREVRLVTK DSKHRNGDPI VLCFVDFTNP ACAATALSAL
210 220 230
QGYRMDENES DSKFLRLQFS RKPGSRPGQR GRR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AWC8 | A0A1P8AWC8_ARATH | RNA-binding (RRM/RBD/RNP motifs) fa... | At1g76940, F22K20.4, F22K20_4 | 179 | Annotation score: |
Sequence cautioni
The sequence AAC00617 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC42194 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057907 | 28 – 81 | Missing in isoform 2. Add BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002291 Genomic DNA Translation: AAC00617.1 Sequence problems. CP002684 Genomic DNA Translation: AEE35906.1 CP002684 Genomic DNA Translation: AEE35907.1 BT029526 mRNA Translation: ABL66782.1 AK117533 mRNA Translation: BAC42194.1 Different initiation. |
PIRi | C96798 |
RefSeqi | NP_001185414.1, NM_001198485.1 [A1A6K6-2] NP_177820.2, NM_106345.4 [A1A6K6-1] |
Genome annotation databases
EnsemblPlantsi | AT1G76940.1; AT1G76940.1; AT1G76940 [A1A6K6-1] AT1G76940.2; AT1G76940.2; AT1G76940 [A1A6K6-2] |
GeneIDi | 844029 |
Gramenei | AT1G76940.1; AT1G76940.1; AT1G76940 [A1A6K6-1] AT1G76940.2; AT1G76940.2; AT1G76940 [A1A6K6-2] |
KEGGi | ath:AT1G76940 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002291 Genomic DNA Translation: AAC00617.1 Sequence problems. CP002684 Genomic DNA Translation: AEE35906.1 CP002684 Genomic DNA Translation: AEE35907.1 BT029526 mRNA Translation: ABL66782.1 AK117533 mRNA Translation: BAC42194.1 Different initiation. |
PIRi | C96798 |
RefSeqi | NP_001185414.1, NM_001198485.1 [A1A6K6-2] NP_177820.2, NM_106345.4 [A1A6K6-1] |
3D structure databases
AlphaFoldDBi | A1A6K6 |
SMRi | A1A6K6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT1G76940.1 |
Proteomic databases
PaxDbi | A1A6K6 |
ProteomicsDBi | 249072 [A1A6K6-1] |
Genome annotation databases
EnsemblPlantsi | AT1G76940.1; AT1G76940.1; AT1G76940 [A1A6K6-1] AT1G76940.2; AT1G76940.2; AT1G76940 [A1A6K6-2] |
GeneIDi | 844029 |
Gramenei | AT1G76940.1; AT1G76940.1; AT1G76940 [A1A6K6-1] AT1G76940.2; AT1G76940.2; AT1G76940 [A1A6K6-2] |
KEGGi | ath:AT1G76940 |
Organism-specific databases
Araporti | AT1G76940 |
TAIRi | locus:2025232, AT1G76940 |
Phylogenomic databases
eggNOGi | ENOG502S9VX, Eukaryota |
HOGENOMi | CLU_078642_1_1_1 |
InParanoidi | A1A6K6 |
OMAi | AMDEFMM |
PhylomeDBi | A1A6K6 |
Miscellaneous databases
PROi | PR:A1A6K6 |
Gene expression databases
ExpressionAtlasi | A1A6K6, baseline and differential |
Genevisiblei | A1A6K6, AT |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NSRA_ARATH | |
Accessioni | A1A6K6Primary (citable) accession number: A1A6K6 Secondary accession number(s): F4I435, O49280, Q8GYL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 14, 2015 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names