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UniProtKB - A1A5Z0 (G6PC3_DANRE)
Protein
Glucose-6-phosphatase 3
Gene
g6pc3
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).
By similarityCatalytic activityi
- EC:3.1.3.9
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 79 | SubstrateSequence analysis | 1 | |
Active sitei | 114 | Proton donorSequence analysis | 1 | |
Binding sitei | 161 | SubstrateSequence analysis | 1 | |
Active sitei | 167 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- glucose-6-phosphatase activity Source: GO_Central
GO - Biological processi
- gluconeogenesis Source: GO_Central
- glucose 6-phosphate metabolic process Source: GO_Central
- hematopoietic progenitor cell differentiation Source: ZFIN
Keywordsi
Molecular function | Hydrolase |
Biological process | Gluconeogenesis |
Enzyme and pathway databases
Reactomei | R-DRE-70263, Gluconeogenesis |
UniPathwayi | UPA00138 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:g6pc3 ORF Names:zgc:158425 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-061215-19, g6pc3 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | LumenalSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 47 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 48 – 54 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 114 | LumenalSequence analysisAdd BLAST | 39 | |
Transmembranei | 115 – 132 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 133 – 143 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 144 – 164 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 165 – 169 | LumenalSequence analysis | 5 | |
Transmembranei | 170 – 186 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 187 – 195 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 308 | LumenalSequence analysisAdd BLAST | 92 | |
Transmembranei | 309 – 329 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 330 – 339 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000334515 | 1 – 339 | Glucose-6-phosphatase 3Add BLAST | 339 |
Proteomic databases
PaxDbi | A1A5Z0 |
PeptideAtlasi | A1A5Z0 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glucose-6-phosphatase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QS5D, Eukaryota |
InParanoidi | A1A5Z0 |
OrthoDBi | 743717at2759 |
PhylomeDBi | A1A5Z0 |
Family and domain databases
InterProi | View protein in InterPro IPR016275, Glucose-6-phosphatase IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
PIRSFi | PIRSF000905, Glucose-6-phosphatase, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A1A5Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESLYRQGVW MAEALQQNSR SLEDLWLVAS HMGDPKAAVL LVFPVVFYIH
60 70 80 90 100
RRTGIAVLWV AALSEWLNLV FKWILFGERP YWWIGQSGLF SEKPPEVQQF
110 120 130 140 150
QSTCESGPGS PSGHAMVTSA VWWVIISSLA SFSQAYTGSK ILSAVLYLLY
160 170 180 190 200
AVFLGCVGLS RIFILAHFPH QVVAGLLTGV LLGVFLKRSV PERRPLLFFF
210 220 230 240 250
RFSMALLGAA LIFHAVLEKT GIDLSWSISL AKRWCSRSEW VRMDTAPFSS
260 270 280 290 300
LNRDAGVLLG LGLAQYWKPG GWTLPRAPRT LCLALSSLAL HYISRFPLPT
310 320 330
VPPLLFYSLF FLKYSIVPQV VMVLVPGFVH LLTAKPKRE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1QI88 | F1QI88_DANRE | Glucose-6-phosphatase | g6pc3 | 339 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC128866 mRNA Translation: AAI28867.1 |
RefSeqi | NP_001073535.1, NM_001080066.1 |
Genome annotation databases
GeneIDi | 790919 |
KEGGi | dre:790919 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC128866 mRNA Translation: AAI28867.1 |
RefSeqi | NP_001073535.1, NM_001080066.1 |
3D structure databases
SMRi | A1A5Z0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000027964 |
Proteomic databases
PaxDbi | A1A5Z0 |
PeptideAtlasi | A1A5Z0 |
Genome annotation databases
GeneIDi | 790919 |
KEGGi | dre:790919 |
Organism-specific databases
CTDi | 92579 |
ZFINi | ZDB-GENE-061215-19, g6pc3 |
Phylogenomic databases
eggNOGi | ENOG502QS5D, Eukaryota |
InParanoidi | A1A5Z0 |
OrthoDBi | 743717at2759 |
PhylomeDBi | A1A5Z0 |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
Reactomei | R-DRE-70263, Gluconeogenesis |
Miscellaneous databases
PROi | PR:A1A5Z0 |
Family and domain databases
InterProi | View protein in InterPro IPR016275, Glucose-6-phosphatase IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
PIRSFi | PIRSF000905, Glucose-6-phosphatase, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G6PC3_DANRE | |
Accessioni | A1A5Z0Primary (citable) accession number: A1A5Z0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families