Prpf6

Functionⁱ

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.By similarity

GO - Molecular functionⁱ

androgen receptor binding Source: Ensembl
ribonucleoprotein complex binding Source: Ensembl
RNA binding Source: Ensembl
transcription coactivator activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: Ensembl
RNA localization Source: Ensembl
spliceosomal tri-snRNP complex assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-RNO-72163 mRNA Splicing - Major Pathway R-RNO-72165 mRNA Splicing - Minor Pathway

Reactomeⁱ

R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pre-mRNA-processing factor 6 Alternative name(s): PRP6 homolog U5 snRNP-associated 102 kDa protein Short name: U5-102 kDa protein
Gene namesⁱ	Name:Prpf6
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	1307103 Prpf6

RGDⁱ

1307103 Prpf6

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000413096	1 – 941	Pre-mRNA-processing factor 6Add BLAST		941

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	180	PhosphothreonineBy similarity	1
Modified residueⁱ	266	PhosphothreonineBy similarity	1
Modified residueⁱ	275	PhosphothreonineBy similarity	1
Modified residueⁱ	279	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	A1A5S1
PeptideAtlas More...PeptideAtlasⁱ	A1A5S1
PRIDEⁱ	A1A5S1

PTM databases

iPTMnetⁱ	A1A5S1
PhosphoSitePlusⁱ	A1A5S1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000051498 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	A1A5S1 RN

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome B complex. Identified in the spliceosome C complex. Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones.By similarity

GO - Molecular functionⁱ

androgen receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	265839, 1 interactor
STRINGⁱ	10116.ENSRNOP00000021723

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1A5S1
SMRⁱ	A1A5S1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	384 – 416	HAT 1Add BLAST	33
Repeatⁱ	418 – 444	HAT 2Add BLAST	27
Repeatⁱ	445 – 476	HAT 3Add BLAST	32
Repeatⁱ	554 – 586	HAT 4Add BLAST	33
Repeatⁱ	588 – 620	HAT 5Add BLAST	33
Repeatⁱ	622 – 654	HAT 6Add BLAST	33
Repeatⁱ	689 – 721	HAT 7Add BLAST	33
Repeatⁱ	723 – 755	HAT 8Add BLAST	33
Repeatⁱ	855 – 887	HAT 9Add BLAST	33

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	67 – 72	Poly-Asp		6

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0495 Eukaryota ENOG410XRKD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075016
HOGENOMⁱ	HOG000116247
HOVERGENⁱ	HBG023330
InParanoidⁱ	A1A5S1
KEGG Orthology (KO) More...KOⁱ	K12855
OMAⁱ	LIMRGCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01F5
PhylomeDBⁱ	A1A5S1
TreeFamⁱ	TF105743

Family and domain databases

Gene3Dⁱ	1.25.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR003107 HAT IPR010491 PRP1_N IPR027108 Prp6/Prp1/STA1 IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat
PANTHERⁱ	PTHR11246:SF1 PTHR11246:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06424 PRP1_N, 1 hit
SMARTⁱ	View protein in SMART SM00386 HAT, 13 hits SM00028 TPR, 4 hits
SUPFAMⁱ	SSF48452 SSF48452, 4 hits
PROSITEⁱ	View protein in PROSITE PS50293 TPR_REGION, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A1A5S1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP 
        60         70         80         90        100
PGKRTVGDQM KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE 
       110        120        130        140        150
ADAIYAALDK RMDERRKERR EQREKEEIEK YRMERPKIQQ QFSDLKRKLA 
       160        170        180        190        200
EVTEEEWLSI PEVGDARNKR QRNPRYEKLT PVPDSFFAKH LQTGENHTSV 
       210        220        230        240        250
DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM RKIGQARNTL 
       260        270        280        290        300
MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 
       310        320        330        340        350
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA 
       360        370        380        390        400
RLQPGDTAKA VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV 
       410        420        430        440        450
PNSVRLWKAA VELEEPEDAR IMLSRAVECC PTSVELWLAL ARLETYENAR 
       460        470        480        490        500
KVLNKARENI PTDRHIWITA AKLEEANGNT QMVEKIIDRA ITSLRANGVE 
       510        520        530        540        550
INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK HTWMEDADSC 
       560        570        580        590        600
VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 
       610        620        630        640        650
VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK 
       660        670        680        690        700
LESENNEYER ARRLLAKARS SAPTARVFMK SVKLEWVLGN ITAAQELCEE 
       710        720        730        740        750
ALRHYEDFPK LWMMKGQIEE QGELMERARE AYNQGLKKCP HSTPLWLLLS 
       760        770        780        790        800
RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM 
       810        820        830        840        850
AKALQECPNS GILWSEAVFL EARPQRKTKS VDALKKCEHD PHVLLAVAKL 
       860        870        880        890        900
FWSERKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR 
       910        920        930        940 
CENAEPRHGE LWCAVSKDIT NWQRKIGEIL VLVAARIKNT F

Length:941

Mass (Da):106,764

Last modified:January 23, 2007 - v1

Checksum:ⁱ12F1405BD6433254

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474066 Genomic DNA Translation: EDL88695.1 BC128779 mRNA Translation: AAI28780.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073234.1, NM_001079766.1
UniGeneⁱ	Rn.17062

Genome annotation databases

Ensemblⁱ	ENSRNOT00000083423; ENSRNOP00000073536; ENSRNOG00000051498
GeneIDⁱ	366276
KEGGⁱ	rno:366276
UCSC genome browser More...UCSCⁱ	RGD:1307103 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A1A5S1	Pre-mRNA-processing factor 6	)	HUMAN		941	UniRef90_O94906
Pre-mRNA-processing factor 6		PONAB		941
Pre-mRNA-processing factor 6		MOUSE		941
PRP6 pre-mRNA processing factor 6 homolog		PANTR		941
Uncharacterized protein		PANPA		941
+173

Protein	Similar proteins		Species	Score	Length	Source
A1A5S1	Pre-mRNA-processing factor 6	)	HUMAN		941	UniRef50_O94906
Pre-mRNA-processing factor 6		MOUSE		941
Pre-mRNA-processing factor 6		PONAB		941
PRP6 pre-mRNA processing factor 6 homolog		PANTR		941
Uncharacterized protein		PANPA		941
+369

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474066 Genomic DNA Translation: EDL88695.1 BC128779 mRNA Translation: AAI28780.1
RefSeqⁱ	NP_001073234.1, NM_001079766.1
UniGeneⁱ	Rn.17062

3D structure databases

ProteinModelPortalⁱ	A1A5S1
SMRⁱ	A1A5S1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	265839, 1 interactor
STRINGⁱ	10116.ENSRNOP00000021723

PTM databases

iPTMnetⁱ	A1A5S1
PhosphoSitePlusⁱ	A1A5S1

Proteomic databases

PaxDbⁱ	A1A5S1
PeptideAtlasⁱ	A1A5S1
PRIDEⁱ	A1A5S1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000083423; ENSRNOP00000073536; ENSRNOG00000051498
GeneIDⁱ	366276
KEGGⁱ	rno:366276
UCSCⁱ	RGD:1307103 rat

Organism-specific databases

CTDⁱ	24148
RGDⁱ	1307103 Prpf6

Phylogenomic databases

eggNOGⁱ	KOG0495 Eukaryota ENOG410XRKD LUCA
GeneTreeⁱ	ENSGT00550000075016
HOGENOMⁱ	HOG000116247
HOVERGENⁱ	HBG023330
InParanoidⁱ	A1A5S1
KOⁱ	K12855
OMAⁱ	LIMRGCE
OrthoDBⁱ	EOG091G01F5
PhylomeDBⁱ	A1A5S1
TreeFamⁱ	TF105743

Enzyme and pathway databases

Reactomeⁱ	R-RNO-72163 mRNA Splicing - Major Pathway R-RNO-72165 mRNA Splicing - Minor Pathway

Reactomeⁱ

R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A1A5S1

PROⁱ

PR:A1A5S1

Gene expression databases

Bgeeⁱ	ENSRNOG00000051498 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	A1A5S1 RN

Family and domain databases

Gene3Dⁱ	1.25.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR003107 HAT IPR010491 PRP1_N IPR027108 Prp6/Prp1/STA1 IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat
PANTHERⁱ	PTHR11246:SF1 PTHR11246:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF06424 PRP1_N, 1 hit
SMARTⁱ	View protein in SMART SM00386 HAT, 13 hits SM00028 TPR, 4 hits
SUPFAMⁱ	SSF48452 SSF48452, 4 hits
PROSITEⁱ	View protein in PROSITE PS50293 TPR_REGION, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRP6_RAT
Accessionⁱ	A1A5S1Primary (citable) accession number: A1A5S1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1A5S1 (PRP6_RAT)

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Pre-mRNA-processing factor 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ