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Protein

Sperm motility kinase

Gene

Smok

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in sperm motility, especially in the regulation of flagellar function.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53ATPPROSITE-ProRule annotation1
Active sitei142Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 38ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm motility kinase (EC:2.7.11.1)
Gene namesi
Name:Smok
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1562638 RGD1562638

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078781 – 654Sperm motility kinaseAdd BLAST654

Proteomic databases

PaxDbiA1A5Q6
PeptideAtlasiA1A5Q6
PRIDEiA1A5Q6

Expressioni

Gene expression databases

BgeeiENSRNOG00000022181 Expressed in 3 organ(s), highest expression level in testis

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033067

Structurei

3D structure databases

ProteinModelPortaliA1A5Q6
SMRiA1A5Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 271Protein kinasePROSITE-ProRule annotationAdd BLAST248
Domaini289 – 329UBAAdd BLAST41

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00910000144203
HOGENOMiHOG000231804
HOVERGENiHBG069424
InParanoidiA1A5Q6
OMAiCCLPIER
OrthoDBiEOG091G09HY
PhylomeDBiA1A5Q6

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A1A5Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRWQVCQDL RSSPFQEDAL TDHYRILASL GQGGFGEVKL ASHLLTQTKV
60 70 80 90 100
AIKVLPKSNK NLLLKSEIEI MKSLDHPHII KLLHIIDTNE NIFIVLEHAV
110 120 130 140 150
GGELLTRIED FGYLPEEECN RLFRQMVLAL QYCHQRGIIH RDIKPENILL
160 170 180 190 200
DHKGNVKLSD FGLSTKIVMG QKLTTLCGTL PYCAPELFNL NGYDGQAIDV
210 220 230 240 250
WSLGVVLYYM ATGCLPFQGF TYQAIKQKIL SGRYSVNFRL SPDLWDVIAK
260 270 280 290 300
LLTVNPRERP RVHEILRFNW LKNENEVSPS SLGGNTDSHP DPTILVMMGD
310 320 330 340 350
MGYEQGQIRE SLRERKFDQV MATYLMLREK ACSEDKSIKT PHPTQCAQTL
360 370 380 390 400
KSTGSTTEKQ TTLRRGSSLP TLTTFYLPSK LESLNKEKRT TMRHTMPPNL
410 420 430 440 450
NCFNKSESLN KGRRTIVSHT ISPTLNCFNK SESLNKGKRT IVRHTMPPKK
460 470 480 490 500
TSPVRRICPR LHKSFGMGSA SEDSSKRNSS DPSLTIFSSQ SFMSAFKYGS
510 520 530 540 550
TYSKRKAFLQ CILHYHASQE EDQYKTTIIP SGKLNTTVPP NSLQEDQPTG
560 570 580 590 600
HLHNVLTAGA VDNRNLQEKS PPFSTTATKG EGPAIKERES IPSSPRAPRE
610 620 630 640 650
QFRGRSQTPP RAPFRRRVWK TLKSGFLKGL GSLCCCLPIQ KKVHPASNRV

PPMK
Length:654
Mass (Da):73,847
Last modified:January 23, 2007 - v1
Checksum:iBDEACD7B3484558B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128761 mRNA Translation: AAI28762.1
RefSeqiNP_001094414.1, NM_001100944.1
XP_017443089.1, XM_017587600.1
XP_017443090.1, XM_017587601.1
XP_017455531.1, XM_017600042.1
UniGeneiRn.144145

Genome annotation databases

EnsembliENSRNOT00000039592; ENSRNOP00000033067; ENSRNOG00000022181
GeneIDi103693984
290818
KEGGirno:103693984
rno:290818
UCSCiRGD:1562638 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128761 mRNA Translation: AAI28762.1
RefSeqiNP_001094414.1, NM_001100944.1
XP_017443089.1, XM_017587600.1
XP_017443090.1, XM_017587601.1
XP_017455531.1, XM_017600042.1
UniGeneiRn.144145

3D structure databases

ProteinModelPortaliA1A5Q6
SMRiA1A5Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033067

Proteomic databases

PaxDbiA1A5Q6
PeptideAtlasiA1A5Q6
PRIDEiA1A5Q6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039592; ENSRNOP00000033067; ENSRNOG00000022181
GeneIDi103693984
290818
KEGGirno:103693984
rno:290818
UCSCiRGD:1562638 rat

Organism-specific databases

CTDi290818
RGDi1562638 RGD1562638

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00910000144203
HOGENOMiHOG000231804
HOVERGENiHBG069424
InParanoidiA1A5Q6
OMAiCCLPIER
OrthoDBiEOG091G09HY
PhylomeDBiA1A5Q6

Miscellaneous databases

PROiPR:A1A5Q6

Gene expression databases

BgeeiENSRNOG00000022181 Expressed in 3 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMK_RAT
AccessioniPrimary (citable) accession number: A1A5Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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