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Entry version 82 (02 Jun 2021)
Sequence version 1 (23 Jan 2007)
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Protein

Melanoma-associated antigen E1

Gene

Magee1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity).

By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTumor antigen
Biological processUbl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanoma-associated antigen E1
Alternative name(s):
Alpha-dystrobrevin-associated MAGE Protein
Short name:
DAMAGE
MAGE-E1 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Magee1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X
  • UP000234681 Componentsi: Chromosome x, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1560259, Magee1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004043001 – 933Melanoma-associated antigen E1Add BLAST933

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1A5P9

PRoteomics IDEntifications database

More...
PRIDEi
A1A5P9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1A5P9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1A5P9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000002660, Expressed in Ammon's horn and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1A5P9, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DTNA.

Interacts with TRIM28.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
261486, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000054396

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A1A5P9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini467 – 666MAGE 1PROSITE-ProRule annotationAdd BLAST200
Domaini721 – 912MAGE 2PROSITE-ProRule annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 113DisorderedSequence analysisAdd BLAST113
Regioni149 – 236DisorderedSequence analysisAdd BLAST88
Regioni256 – 282DisorderedSequence analysisAdd BLAST27
Regioni360 – 393DisorderedSequence analysisAdd BLAST34
Regioni719 – 933Interaction with DTNABy similarityAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 100Polar residuesSequence analysisAdd BLAST41
Compositional biasi149 – 186Polar residuesSequence analysisAdd BLAST38
Compositional biasi194 – 236Polar residuesSequence analysisAdd BLAST43
Compositional biasi256 – 278Polar residuesSequence analysisAdd BLAST23
Compositional biasi376 – 392Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163182

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012911_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1A5P9

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRPITDC

Database of Orthologous Groups

More...
OrthoDBi
1195799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1A5P9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1200, 2 hits
1.10.10.1210, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037445, MAGE
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11736, PTHR11736, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01454, MAGE, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373, MAGE, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838, MAGE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1A5P9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVSQNSRR RRGGRANGRK NSGKGRPAAV PGPAVPRDRS DPQILQGLGA
60 70 80 90 100
TEGPGTSVLP TPRGGSSTSV PPTASEGSSA PGQLITSEGR NTSQLPTSRK
110 120 130 140 150
GRGTRRPPAV SAGLNAAASI TASEGASTPV LPTAPKGSKA SEHLTISEGA
160 170 180 190 200
SISEQPQSHE GPNVQPTLGE GSGTSVPPTF SEESGISEPL PSGEGLSISV
210 220 230 240 250
SPTISEGAGI NEPSPASKAP STSVPPTASN GLGINLPPTS SEGLSISVLF
260 270 280 290 300
SASEESDISV PPPSAEGLST SMPPPSGEVQ STWVPPIILE GCSVKVRSTS
310 320 330 340 350
RKGRRTPVRS AACESPSPSA ECLSTSLSSI SAEGFCSSLA PCAEGSDTCE
360 370 380 390 400
LLPCGEGPST SGLHDLEEES SISQMPLAAE GPSASGSSIE DENPEEALSC
410 420 430 440 450
GASVGMNLCK CTSLALQKAD DPSVRPKRAE GFLDFQVLRD SENSNSITIM
460 470 480 490 500
GLGTAHVALT LKPQDPMEQN VAELLQFLLL KDQTKYPIKE SEMREFIVQE
510 520 530 540 550
YRNQFPEILR RAAAHLECIF RFELKELDPE EHTYILLNKL GPVPFEGLED
560 570 580 590 600
IPNGPKMGLL MMILGQIFLN GNQAREADIW EMLWRFGVQR ERRLSVFGNP
610 620 630 640 650
KRLLSVEFVW QRYLDYRPIT DCVPVEYEFY WGPRSHVETT KMKILKFMAR
660 670 680 690 700
IYNKDPMDWP AQYNEALEEE AERDVPNNWR AVPHFRRPLF QEVSPELLAS
710 720 730 740 750
DSDAPGCPSK YSPHSWPESR LESKSRKLVQ LFLLMDSTKL PIPKKGILYY
760 770 780 790 800
IGRECSKVFP DLLNRAARTL NHVYGTELVV LDPRNHSYTL YNRREMEDME
810 820 830 840 850
EIMDSPNRPG NNFLMQVLSF IFIMGNHARE SAVWAFLRGL GVQNGRKHVI
860 870 880 890 900
TCRYLSQRYI DSLRVPDSDP VQYDFVWGPR ARLETSKMKA LRYVARIHRK
910 920 930
EPQDWPDQYR EALEDEANRA EAGRRPLVVR NLR
Length:933
Mass (Da):102,181
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51060923ECC9A7C3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH473969 Genomic DNA Translation: EDM07152.1
BC128754 mRNA Translation: AAI28755.1

NCBI Reference Sequences

More...
RefSeqi
NP_001073360.1, NM_001079891.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000003573; ENSRNOP00000054396; ENSRNOG00000002660

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
317232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:317232

UCSC genome browser

More...
UCSCi
RGD:1560259, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473969 Genomic DNA Translation: EDM07152.1
BC128754 mRNA Translation: AAI28755.1
RefSeqiNP_001073360.1, NM_001079891.1

3D structure databases

SMRiA1A5P9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi261486, 1 interactor
STRINGi10116.ENSRNOP00000054396

PTM databases

iPTMnetiA1A5P9
PhosphoSitePlusiA1A5P9

Proteomic databases

PaxDbiA1A5P9
PRIDEiA1A5P9

Genome annotation databases

EnsembliENSRNOT00000003573; ENSRNOP00000054396; ENSRNOG00000002660
GeneIDi317232
KEGGirno:317232
UCSCiRGD:1560259, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57692
RGDi1560259, Magee1

Phylogenomic databases

eggNOGiKOG4562, Eukaryota
GeneTreeiENSGT00940000163182
HOGENOMiCLU_012911_0_0_1
InParanoidiA1A5P9
OMAiYRPITDC
OrthoDBi1195799at2759
PhylomeDBiA1A5P9

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A1A5P9

Gene expression databases

BgeeiENSRNOG00000002660, Expressed in Ammon's horn and 21 other tissues
GenevisibleiA1A5P9, RN

Family and domain databases

Gene3Di1.10.10.1200, 2 hits
1.10.10.1210, 2 hits
InterProiView protein in InterPro
IPR037445, MAGE
IPR041898, MAGE_WH1
IPR041899, MAGE_WH2
IPR002190, MHD_dom
PANTHERiPTHR11736, PTHR11736, 5 hits
PfamiView protein in Pfam
PF01454, MAGE, 2 hits
SMARTiView protein in SMART
SM01373, MAGE, 2 hits
PROSITEiView protein in PROSITE
PS50838, MAGE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGE1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1A5P9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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