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Protein

Ribosome biogenesis regulatory protein homolog

Gene

Rrs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis regulatory protein homolog
Gene namesi
Name:Rrs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311403 Rrs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277461 – 365Ribosome biogenesis regulatory protein homologAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei273CitrullineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA1A5P2
PeptideAtlasiA1A5P2
PRIDEiA1A5P2

PTM databases

iPTMnetiA1A5P2
PhosphoSitePlusiA1A5P2

Expressioni

Gene expression databases

BgeeiENSRNOG00000007240 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiA1A5P2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009482

Structurei

3D structure databases

SMRiA1A5P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi302 – 365Arg/Gly/Lys-richAdd BLAST64

Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

eggNOGiKOG1765 Eukaryota
COG5225 LUCA
GeneTreeiENSGT00390000005213
HOGENOMiHOG000017552
HOVERGENiHBG036121
InParanoidiA1A5P2
KOiK14852
OMAiKRKFQPL
OrthoDBiEOG091G0I2Z
PhylomeDBiA1A5P2
TreeFamiTF313067

Family and domain databases

InterProiView protein in InterPro
IPR007023 Ribosom_reg
PANTHERiPTHR17602 PTHR17602, 1 hit
PfamiView protein in Pfam
PF04939 RRS1, 1 hit

Sequencei

Sequence statusi: Complete.

A1A5P2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGQSVEELL AKAKQEEAEK LQRITVHKEL ELEFDLGNLL ASDRNPPTVL
60 70 80 90 100
RQAGPSPEAE LRALARDNTQ LLVNQLWQLP TERVEEAVVA RLPEPATRLP
110 120 130 140 150
REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEVSGQW RRRWGYKRAR
160 170 180 190 200
DDTKEWLIEV PGSADPMEDQ FAKRIRAKKE RVAKNELNRL RNLARAHKMQ
210 220 230 240 250
MPSSAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKAPRGSGK
260 270 280 290 300
KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA
310 320 330 340 350
AKRRKMSQKG KKKGGRQGPS GRRKGGPPSQ GEKRKGVLGG KKHSRPPALG
360
GKKKGVPHHG GKRRK
Length:365
Mass (Da):41,537
Last modified:January 23, 2007 - v1
Checksum:iA4D78481B81899A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128746 mRNA Translation: AAI28747.1
RefSeqiNP_001073167.1, NM_001079699.1
UniGeneiRn.228976

Genome annotation databases

EnsembliENSRNOT00000009482; ENSRNOP00000009482; ENSRNOG00000007240
GeneIDi297784
KEGGirno:297784
UCSCiRGD:1311403 rat

Similar proteinsi

Entry informationi

Entry nameiRRS1_RAT
AccessioniPrimary (citable) accession number: A1A5P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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